Adult intestinal size plasticity is driven not only by epithelial stem cells but also by remodeling of the surrounding visceral musculature. Sex- and reproduction-dependent muscle remodeling controls ...

Abstract. There is growing interest in the use of molecular features as predictors of age, age-related disease risk and mortality. A major shortcoming of t

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Deep3DSIM enables super-resolution imaging >130 µm into complex tissues of fixed and live specimens in an upright configuration, allowing sample manipulation, as well as rapid refocusing without th...

Nagy et al. identify a NOX-ATM-cytokine signaling axis in the Drosophila gut that is activated by infection independently of DNA damage. This pathway promotes enterocyte loss, cytokine production, and...

The evolutionary dynamics of immune genes are shaped by diverse selective pressures, yet the relative roles of gene-level traits, functional specialization, and pathway context remain poorly understoo...

Abstract. The ever-increasing amounts of plastic waste and greenhouse gas emissions worldwide threaten our environment. Biomedical laboratories across the

Sexual selection acts on heritable differences within species, driving the parallel diversification of signal production in one sex and behavioral responses in the other. This coevolution implies that...

Gaucher disease (GD), the most common lysosomal storage disorder, is caused by bi-allelic mutations in the GBA1 gene. Variants in GBA1 also represent the most frequent genetic risk factor for Parkinso...

Human longevity, which is coupled to compression of age-related disease, is a heritable trait. However, only few common genetic variants have been linked to longevity, suggesting that rare, family-spe...

It is widely accepted that susceptibility to infection increases with age. The reason often invoked is the dysregulation of the immune system, which is both cause and consequence of ageing. However, w...

Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

Background Drosophila melanogaster has been a valuable model for dissecting the molecular architecture of innate immunity. However, the family Drosophilidae encompasses over 4000 species, spanning dee...

A mathematical model of pathogen within-host dynamics and experimental validations elucidates the interplay between immune response, damage and pathogen proliferation, highlighting the limitations of ...

The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon...

Adult tissue function is dependent on intrinsic factors that mediate stem cell self-renewal and proliferation in response to changes in physiology and…

Join this year's Tam Dalyell Prize for Excellence in Engaging the Public with Science winners to hear about their work with rural schools.

Stem cell self-renewal and proper tissue function rely on conserved metabolic regulators to balance energy production with inter-organ metabolic trafficking. The estrogen-related receptor (ERR) subfam...

Colonisation of the mosquito by the malarial parasite is critically reliant on the invasive ookinete stage. Ookinete invasion of mosquito is coordinated by the apical complex, a specialised parasite s...

PhD Project - EastBio: Identifying tissue signals that control cellular longevity at University of Edinburgh, listed on FindAPhD.com

Organisms regulate their feeding behavior to prevent overconsumption of certain nutrients. Here, the authors identify the importance of gut hormones in suppressing protein overfeeding.

PhD Project - EastBio: Investigating the interplay between obesity and immune dysfunction using Drosophila at University of Edinburgh, listed on FindAPhD.com

We offer up to 30 scholarships to displaced people to study on a full-time postgraduate programme at the University of Edinburgh, starting in September 2025. Applications will open on 2 December 2024 ...

PhD Project - EastBio: Microbiota and immune regulation at barrier sites – from wild to germ-free mice at University of Edinburgh, listed on FindAPhD.com