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Kathryn McGurk

@kathrynmcgurk.bsky.social
209 followers 136 following 14 posts

Cardiovascular Geneticist / Bioinformatician 🇮🇪 BHF Immediate Research Fellow at Imperial College London, UK. profiles.imperial.ac.uk/k.mcgurk

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Reposted by Kathryn McGurk
Imperial Medicine @imperialmed.bsky.social · 22/01/2026
The protein that lets #COVID19 into cells may also protect against high blood pressure and #diabetes 🫀 Scientists at @imperialcollegeldn.bsky.social & @mrc-lms.bsky.social have uncovered a surprising new role for #ACE2. More 👇 www.imperial.ac.uk/news/article... #T2D @imperialnhli.bsky.social
imperial.ac.uk
ACE2 - from MRC LMS
A collaborative study from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London has found that the protein ACE2 may play a protec...
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Reposted by Kathryn McGurk
MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 22/12/2025
A new study has found that the protein ACE2 may play a protective role against two common conditions, high blood pressure and type-2 diabetes, which affect millions of people worldwide. The study was led by @kathrynmcgurk.bsky.social at the LMS and @imperialnhli.bsky.social
lms.mrc.ac.uk
Key protein ACE2 could protect against high blood pressure and diabetes
A collaborative study from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London has found that the protein ACE2 may play a protective role against two common conditions, high blood...
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Kathryn McGurk @kathrynmcgurk.bsky.social · 27/05/2025
Double representation from @cvgenomics.bsky.social 💪 ( @jamesware.bsky.social ) 🧬 🫀
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Reposted by Kathryn McGurk
Pilar Cacheiro @pilarcacheiro.bsky.social · 25/05/2025
Kathryn McGurk: Penetrance of secondary findings in inherited cardiomyopathies. - Bluesky exchange on the slides - Pathogenicity vs penetrance - Estimates of prevalence are uncertain - Men have increased penetrance -Cut-off for high/medium/low penetrance? #ESHG2025
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Kathryn McGurk @kathrynmcgurk.bsky.social · 25/05/2025
Increase your step count before your next round of pasta tonight, and come chat penetrance with us in the final session of today at 5.15pm in the auditorium #ESHG2025 🍝
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Reposted by Kathryn McGurk
Jodie Ingles @jodieingles27.bsky.social · 17/04/2025
Our paper now published! 🙌🏻🧬🫀 @alexbutters25.bsky.social @k-jt.bsky.social @njhenden.bsky.social @dgmacarthur.bsky.social @kathrynmcgurk.bsky.social @jamesware.bsky.social @sharday-penn.bsky.social @rdbagnall.bsky.social @garvaninstitute.bsky.social @escardio.bsky.social doi.org/10.1093/eurh...
doi.org
A rare splice-site variant in TNNT2: the need for ancestral diversity in genomic reference data sets
Inherited cardiomyopathies, including hypertrophic (HCM), dilated (DCM), and restrictive (RCM) cardiomyopathies affect ∼1 in 200–500 in the population. Gen
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Kathryn McGurk @kathrynmcgurk.bsky.social · 07/04/2025
Excited to discuss our work on penetrance at #ESHG2025 in Milan, Sun 25th May at 5.15pm CEST. Thanks to @eshg.bsky.social for their support while I’m on maternity leave 👶🏼 2025.eshg.org/speakers/
2025.eshg.org
Speakers
Meet our confirmed conference speakers for the 2025 conference. Kaur Alasoo, Estonia Laura Arbour, Canada Mary Armanios, United States Hassan Arsalan, Pakistan Anna Aschenbrenner, Germany Ro...
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Reposted by Kathryn McGurk
Jodie Ingles @jodieingles27.bsky.social · 05/03/2025
Let me tell you a story about 2 patients we identified, both with a rare variant in TNNT2; NM_001001430.3: c.571-1G>A. Both had cardiac phenotypes and both had Oceanian ancestry Our latest in EHJ! @alexbutters25.bsky.social @escardio.bsky.social #medsky #genechat #cardiosky doi.org/10.1093/eurh...
doi.org
A rare splice-site variant in TNNT2: the need for ancestral diversity in genomic reference data sets
Inherited cardiomyopathies, including hypertrophic (HCM), dilated (DCM), and restrictive (RCM) cardiomyopathies affect ∼1 in 200–500 in the population. Gen
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Reposted by Kathryn McGurk
The Heart Hive @thehearthive.bsky.social · 19/02/2025
💡 #ResearchSpotlight Emma Jennings is studying Biomedical Science and was diagnosed with dilated cardiomyopathy at the age of 1. Her paper on the needs and potential research avenues for young people with DCM combines her lived experience and her perspective as a scientist. Read more: bit.ly/4gFS6WL
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Reposted by Kathryn McGurk
Ana Morales, MS, CGC, PhDc @amoralescgc.bsky.social · 06/02/2025
🫀🧬 Science is a social process, and translating knowledge into action requires understanding patient perspectives. Let’s prioritize research questions that address the concerns of the communities we serve!
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Kathryn McGurk @kathrynmcgurk.bsky.social · 06/02/2025
Fantastic to work with Emma, a patient-scientist with DCM, on this review informed by her perspective, please check it out! www.cambridge.org/core/journal...
cambridge.org
Dilated cardiomyopathy in the young: a patient-scientist informed review of unmet needs | Cardiology in the Young | Cambridge Core
Dilated cardiomyopathy in the young: a patient-scientist informed review of unmet needs
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Reposted by Kathryn McGurk
The Heart Hive @thehearthive.bsky.social · 05/02/2025
February is #HeartMonth! Want to get involved in heart research but not sure how? The Heart Hive is an online portal where you can sign up to take part in research studies. Go to thehearthive.org to find out more and register today. #NationalHeartMonth #HeartResearch #ParticipateInResearch
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Reposted by Kathryn McGurk
deciphergenomics.bsky.social @deciphergenomics.bsky.social · 08/01/2025
Estimated population penetrance for variants associated with cardiomyopathies are now displayed alongside cardiac allele frequencies. This information is useful when considering secondary findings @jamesware.bsky.social @kathrynmcgurk.bsky.social
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Kathryn McGurk @kathrynmcgurk.bsky.social · 01/12/2024
New preprint out from some summer explorations into the UK Biobank proteomics data; in-depth genetic and phenotypic analyses of 9 interesting cardiovascular proteins 🫀🧬 www.medrxiv.org/content/10.1...
medrxiv.org
Circulating cardiovascular proteomic associations with genetics and disease
Background The analysis of the circulating proteome can identify translational modifiers and biomarkers of disease expressivity and severity at a given time point. Here we explore the relationships be...
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Kathryn McGurk @kathrynmcgurk.bsky.social · 22/11/2024
We’re really excited to focus on understanding takotsubo cardiomyopathy. Have your say and take part in research to help us find the causes, risks, and treatments 💪🫀🧬 @thebhf.bsky.social
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Reposted by Kathryn McGurk
NHLI @imperialnhli.bsky.social · 22/11/2024
🫀 New research by NHLI & @mrc-lms.bsky.social researchers reveals how our genes influence cardiac trabeculae – a network of heart muscle fibres. @kathrynmcgurk.bsky.social @drdeclanoregan.bsky.social @seanlzheng.bsky.social @jamesware.bsky.social #medsky www.imperial.ac.uk/news/258501/...
imperial.ac.uk
New insights into crucial heart muscles | Imperial News | Imperial College London
Researchers at the MRC Laboratory of Medical Sciences and Imperial College London have unveiled new genes involved in heart fibres called trabeculae
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Reposted by Kathryn McGurk
James Pirruccello 🎃🦇🧹 @jamespirruccello.com · 21/11/2024
Two very nice papers in cardiovascular genetics in two days. The first examines myocardial trabeculation: www.nature.com/articles/s44...
nature.com
Genetic and phenotypic architecture of human myocardial trabeculation - Nature Cardiovascular Research
The inner surface of the heart has a meshwork of muscles called trabeculae. McGurk et al. report the genetic regulation of these complex structures across common and rare variants, revealing pathways ...
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Reposted by Kathryn McGurk
Jodie Ingles @jodieingles27.bsky.social · 21/11/2024
Ive taken this job of finding all of our cardiovascular genomics people and adding them to this starter pack, very seriously. Many newbies just added! And don’t forget our hashtag: #cardiogen #cardiosky #medsky #genechat go.bsky.app/4NjCKhB
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Reposted by Kathryn McGurk
Sean @seanlzheng.bsky.social · 21/11/2024
🧬 Our dilated #cardiomyopathy GWAS out today! 📍https://www.nature.com/articles/s41588-024-01952-y All made possible with friends and collaborators from HERMES Consortium @alberthenry.bsky.social @tomlumbers.bsky.social @jamesware.bsky.social @mrc-lms.bsky.social @imperialnhli.bsky.social #BHF 🧵 👇
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Reposted by Kathryn McGurk
MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 20/11/2024
🫀New paper by @kathrynmcgurk.bsky.social with @drdeclanoregan.bsky.social published today in @natureportfolio.bsky.social describes the genetic architecture of myocardial trabeculae - the network of muscle fibres in the heart.🫀 @imperialnhli.bsky.social @thebhf.bsky.social #Medsky #Cardiosky 🧪
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Kathryn McGurk @kathrynmcgurk.bsky.social · 20/11/2024
Exciting first bluesky post! We estimated trabecular complexity in 50,000 UK Biobank participants to identify influencing genetic, clinical, and lifestyle factors. Trabeculation progresses with cardiac diseases and changes can occur early in pathogenesis.
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