We benchmarked 23 ageing biomarkers and 9703 protein targets for associations with mortality risk. Epigenetic, neuroimaging and functional biomarkers showed the strongest associations, outperforming ....

In this Review, Dimmeler and Augustin discuss microvascular aging as an emerging key driver of tissue dysfunction and systemic decline, highlighting how single-cell and multiomic approaches are uncove...

Longevity is taking off, but regulatory oversight is essential to determining what works—and what doesn’t

Circadian clock disruption and lack of sleep impair organismal health, but remedies remain elusive. Here, we used multi-omics, molecular and functional assays in C. elegans , human retinal cells and m...

Aging in Cladonema medusae disrupts tissue homeostasis and stem cell-associated dynamics, accompanied by delayed wound closure and defective blastema formation. These age-associated cellular changes ....

AMP-activated protein kinase (AMPK) is a key evolutionarily conserved sensor of energy homeostasis, which is implicated in metabolic health and disease, as well as in ageing. Here, we show that direc...

Existing studies focus on endpoints, leaving unambiguous rejuvenation largely undemonstrated. To address this gap, we transplanted white adipose tissue (WAT) between young and old mice and longitudina...

Aging transforms the skeletal muscle microenvironment from a balanced, regenerative niche into a maladaptive, degenerative state. This review highlights how disrupted multicellular crosstalk drives c....

Aging progresses asynchronously across organs, motivating the development of organ-resolved aging clocks. Direct assessment of organ aging in living humans, however, is largely impractical. Here, we c...

Ageing reflects progressive decanalization of mammalian cell identity, driven by erosion of a regulatory grammar written during development.

Deep learning identifies age-associated chromatin architecture signatures in 3D images of hematopoietic stem cell nuclei, providing an interpretable imaging biomarker that distinguishes young from ag...

Abstract figure legend Skeletal muscle structure was analysed at three levels in young vs. aged humans, and in young vs. aged mice subjected to unilateral hindlimb immobilization to model disuse. (1)...

Aging drives chronic disease in part through senescent cells, including macrophages, which fuel inflammation. Senescent macrophages are functionally heterogeneous: canonical p16-high macrophages promo...

Tracking the biological age of grafted organs suggests that donor pools could be expanded to boost organ availability.

Isotope tracing is used to determine the fate of larval dietary amino acids in adult flies, and identifies Lsp2 as a key regulator of translation and lifespan that forms the molecular basis of the eff...

Mutations in the mitochondrial genome (mtDNA) play a critical role in the aging process and a wide variety of age-related diseases. However, it remains unclear when the mutations that drive physiologi...

Reviews nanoparticle applications in diagnosing and treating aging hallmarks, bridging mechanistic studies with translational anti-aging interventions.

Using 38 blood SASP proteins, a guided autoencoder-transformer model generates a composite SASP Score that captures systemic cellular senescence burden. The score predicts mortality and age-related d....

Aging is characterized by progressive molecular dysregulation across interconnected biological systems, involving alterations in epigenetic regulation, gene expression, protein homeostasis, and metabo...

Aging clocks are typically trained on pooled multi-tissue data, implicitly assuming that aging is uniform across organs. Here we challenge this assumption by constructing 49 transcriptomic clocks acro...

Rapamycin exerts multifaceted immunomodulatory effects in age-induced atherosclerosis, with pronounced inhibitory effects on adaptive immunity. Rapamycin reduced plaque inflammation and macrophage co...

Aging is a complex, multifactorial biological process marked by progressive physiological decline and increased vulnerability to chronic disease. Advances in geroscience have expanded the hallmarks of...

Leveraging proteomic data from nearly 15,000 women across several cohorts, this study found that menopause is associated with hormone-linked molecular changes that correlate with poorer cognitive outc...

The authors show that chronic NAD deficiency causes widespread metabolic, physical, and cellular changes, including senescence and inflammation, while dietary niacin restores NAD levels and reverses m...

Grip strength has emerged as one of the most robust predictors of mortality, disability and healthspan across populations. Yet its predictive validity rests ...

Elderly human donor microbiota disrupts intestinal barrier integrity and reshapes host metabolic and mucosal transcriptional profiles in human microbiota-associated pigs. Integrated multi-omics analy...

The capacity for tissue repair and regeneration undergoes a profound and progressive decline across the human lifespan, representing a fundamental driver of ...

Marine organism; Nature conservation; Zoology

New studies pour cold water on a prominent rejuvenation idea.

The cGAS/STING pathway is a central innate immune signaling pathway responsive to cytosolic DNA. Chronic activation of this pathway promotes numerous age-related pathologies, but its impact on lifespa...

Fibrotic remodeling of tissues and tumors establishes immunosuppressive microenvironments that drive organ dysfunction and, in cancer, limit response to immunotherapy. Senescent-like cells are conserv...

Mitochondrial fission-fusion imbalance contributes to age-related cardio-cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction,...

Targeting senescence decreases fibrosis and boosts the response of cancer cells to immunotherapy

Extracellular vesicles from aged bone marrow carry pro-inflammatory cargo that drives blood stem cell decline, while youthful vesicles restore or maintain stem cell function. Circulating vesicles the....

Aging heart shows mitophagy flux congestion and mitochondrial dysfunction. Aberrant activation of the HIF-3α-BNIP3 axis induces mitophagy flux congestion in the aging heart. Mitochondrial transplanta....

Background Despite the growing demand for transplantation, a shortage of donor organs persists, limiting access to this lifesaving procedure. To meet the increasing demand, organs are frequently trans...

Senescent cancer cells exhibit a secretory phenotype, known as SASP, capable of inducing paracrine senescence. However, the main factors within the SASP triggering this process are unknown. Here, we ....

Chromatin modifications on telomeres are linked to the mode of telomere DNA replication. A coupled feedforward loop model is proposed based on these to lock the ALT cancer cells in this alternative m...

Restoring NAD+ to physiological levels shows promise for countering brain aging and neurodegeneration, backed by preclinical and growing clinical evidence. Key challenges remain: measurement validity,...

Using a genome-wide CRISPR screen, the authors demonstrate that excess cysteine drives mitochondrial iron accumulation and iron–sulfur cluster failure, triggering a distinct iron-dependent cell death ...

Scientists are poking holes in established ideas about how cells live and die, and are harnessing these discoveries to fight diseases from cancer to autoimmune conditions.

Gabandé-Rodríguez, Soto-Heredero and colleagues identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated myelopoiesis. CCR5 blockade ...

Mitochondrial dysfunction is a hallmark of aging, yet how mitochondrial states are remodeled across tissues and subcellular compartments in vivo remains elusive. Progress has been limited, in part, be...

Senescence has traditionally been studied largely on the basis of changes in gene expression, but senescent cells also undergo profound biochemical remodeling. Zhang and colleagues introduce RamanOmic...

European Journal of Clinical Nutrition - Meal timing and eating window with all-cause and cardiovascular mortality and life expectancy: population-based cohort study

Nature Aging - European Innovation Council support for healthy aging biotechnology

Muscle regeneration is associated with transient induction of cellular senescence. However, whether this response represents a uniform program or distinct age-dependent senotypes remains unclear. Sing...