We present the development of GlycoStrip, which is a multiplex anti-glycan antibody analysis platform. GlycoStrip incorporates neoglycoproteins and other materials directly printed on nitrocellulose s...

Genome-wide analyses identify 13 loci associated with susceptibility to infection with SARS-CoV-2 Omicron variants, including variation in ST6GAL1, previously associated with influenza susceptibility,...

Combining bioorthogonal protecting groups with localized catalysts that can unmask them is a powerful approach to spatially and temporally modulate molecular activity. Enzymes are appealing catalysts ...

An allosteric site on the E3 ligase adapter cereblon can be targeted to modulate the efficacy of cereblon in targeted protein degradation applications.

Global mean sea level rise amounted to 4.5 mm per year as a result of warming oceans and melting land ice, more than twice the rate of 2.1 mm/year observed at the start of satellite data in 1993, base...

The Office of Science and Technology Policy (OSTP) requests input from all interested parties on Federal policy updates that aim to accelerate the American scientific enterprise, enable groundbreaking...

Botulinum toxins vary in oral toxicity, but the reasons are unclear. Here, the authors show that the differences can be due to variations in one of the toxin’s components, the hemagglutinin complex, w...

The MIRAGE (Minimum Information Required for A Glycomics Experiment) guidelines for mass spectrometry (MS) data were initially developed to standardize the reporting of instrumentation, data acquisiti...

Chiaki Nagai-Okatani, Masae Hosoda, Winnie Hsiung, Takashi Sato, Hiroaki Sakaue, Sayaka Fuseya, Eriko Fukuda, Issaku Yamada, Kiyoko F Aoki-Kinoshita, Atsus

Glyco-immune checkpoints have recently been shown to be critical mediators of immunotherapy resistance across multiple cancer types. In clinical trials, immunotherapeutic treatments for prostate cance...

Authors identify and characterize 16 endo−1,3-fucanases within the GH168 family sequence space, unveiling a recognition mechanism for sulfate polysaccharides. These findings can promote the applicatio...

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Doctoral position in Natural Science Specialising in Biology focusing on Bioinformatics The Department of Chemistry and Molecular

Automate the arcane! Build spell-powered factories, reclaim ancient territories filled with magical secrets, and discover game-changing technology hidden across procedurally generated worlds. Master b...

Oligosaccharyltransferase (OST) catalyses the key step of N-glycosylation, transferring immature N-glycans to select Asn residues in nascent proteins in the endoplasmic reticulum (ER). Asn are more li...

Peptide:N-glycosidases (PNGases) are used by a wide range of organisms to remove N-glycan structures from proteins for use as either nutrients or in glycoprotein processing. PNGaseF is the most well-characterized enzyme of this family and is widely used ...

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The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4-31L and OmcFL3-...