Additional Links Faculty Resources Faculty Highlight Videos Faculty Faculty Awards The 2026-2027 faculty search is now open. Department of Biochemistry, School of Medicine—Basic Sciences Vanderbilt Un...

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review NOT-OD-26-088. NIH

Apurinic/apyrimidinic (AP) sites, also known as abasic sites, are among the most frequent DNA lesions, arising spontaneously or as intermediates in base excision repair. Their structural impediment to...

TPS awards recognize excellence across the diverse disciplines that collectively advance our understanding of proteins; their structure, function, design, and application. The Awards honor…

Alternative polyadenylation (APA) generates transcript isoforms with variable 3′ untranslated regions (UTR) lengths, yet its role in DNA damage respon…

Replicative single-stranded DNA gaps arise when DNA synthesis proceeds past lesions or difficult-to-replicate regions. This review delineates the pathways that generate, stabilize, and process these i...

Nature Communications - Replication fork plasticity upon genotoxic stress is modulated by nuclear architectural components by elusive mechanisms. Here the authors implicate Lamin A/C – best...

Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...

Homologous recombination (HR) deficiency upon Breast Cancer Gene 2 (BRCA2) loss arises from defects in the formation of RAD51 nucleoprotein filaments. We demonstrate that loss of the anti-recombinase ...

Department of Biochemistry, School of Medicine—Basic Sciences

Vanderbilt researchers probe the mysteries of an enzyme that could be used as a tool in basic research and medicinal chemistry.

Funded by the National Cancer Institute (T32CA186895), the program at City of Hope provides exceptionally motivated, recent (2 years or less) postdoctoral fellows with scientific knowledge, researc

Department of Biochemistry, School of Medicine—Basic Sciences

HMCES binding to nascent DNA blocks replication and kills homologous recombination–deficient cancer cells.

8-oxoG is a common single-base DNA lesion caused by oxidative stress. Here, authors characterize the mutational signature of potassium bromate (KBrO3) exposure, the chromatin structural determinants o...