Reposted by Veronica Cherdyntseva
Landing on Bluesky by sharing the latest preprint from the lab: nucleoplasmic Lamin A/C modulates RECQ1-mediated fork restart upon mild genotoxic stress, by regulating heterochromatin marks and ADP-ribosylation levels at replication factories
www.biorxiv.org/content/10.1...
biorxiv.org
Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels
Mild replication interference is a consolidated strategy for cancer chemotherapy. Tolerance to mild replication stress (RS) relies on active fork slowing, mediated by transient fork reversal and RECQ1...