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dayyapparaja.bsky.social

@dayyapparaja.bsky.social
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Alex Eve @amjeve.uk · 26/07/2026
Neha Ahuja studies how pancreatic cell types develop and simultaneously organise and shape into a complex organ, revealing a role for Merlin - a protein that links the cell membrane to intracellular scaffold proteins - in luminogenesis and exocrine acinar cell differentiation. #2026SDB Preprint⤵️
biorxiv.org
Transient architecture of the embryonic pancreas determines endocrine mass
During organogenesis, epithelial tissues undergo extensive three-dimensional (3D) remodeling while simultaneously generating specialized cell types. Whether these transient architectural states active...
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The Vilcek Foundation @vilcekfoundation.bsky.social · 21/07/2026
Through her work at @caltech.edu, Marianne studies stem cell development to advance our understanding of regenerative medicine. She is also a dedicated mentor, helping the next generation of scientists build successful careers. Learn more about our Vilcek Prizewinner: vilcek.co/4vHQbbM
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Mike Piacentino @mikepiacentino.bsky.social · 21/07/2026
Come join us! 🔬🐣 The Piacentino Lab at Johns Hopkins @hopkinsmedicine.bsky.social is recruiting a postdoc to study membrane lipids, cell migration, and invasion in neural crest and embryonic models! @socdevbio.bsky.social @ascbiology.bsky.social #devbiol #cellbio #lipids
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Developmental Biology @devbiol.bsky.social · 21/07/2026
#DBfeature #ICYMI 🐸 MicroRNA miR-196a controls neural crest patterning by repressing immature neural ectoderm programs in Xenopus embryos By Alice Godden, Grant Wheeler, et al. tinyurl.com/4mne33bu
Depletion of miR-196a expands neural plate progenitors at the expense of neural crest specification and neuronal differentiation. Embryos were injected into one dorsal blastomere at the 4-cell stage of development with 300 pg of GFP mRNA or of lacZ developed with Red-gal. In all panels the injected side is to the right. Whole mount in situ hybridisation of zic1, (stage 14), zic3, (stage 14), msx2, (stage 14), sox2, (stage 14), pax6, (stage 15) hairy1, (stage 18), eng2, (stage 15) n-tub (stage 18) and elrc1, (stage 18), following MO mediated miRNA KD. Embryos are positioned in dorsal view with anterior at the top. Whole mounts are shown as well as transverse sections (i). Injection of the MO caused an expansion in the NPB markers Zic1 (n = 28/30) and Zic3 (n = 34/37) but a loss in the anterior region of the NPB marker Msx2 (n = 18/19) (A–C). The neural marker Sox2 was expanded in a lateral direction and appeared to lose the intense dark region of expression seen in the control side (see black arrow) (n = 37/37) (D). Expression of the neural marker Pax6 was slightly enlarged across the anterior neural fold (lens primordia) (see white arrow) but reduced in the position of the forebrain stripe (see black arrow) (n = 18/24) (E). The downstream target of Notch – Hairy1 had a reduced but broadened expression (n = 22/25) (F) Eng2 showed a reduced and broadened expression as well as a shift more posterior (n = 19/25) (G). Both neuronal differentiation markers N-tub (n = 24–30) and ELRC (n = 23/24) were reduced following miR-196aMO injection although this was restricted to the anterior most part of the NP (see black arrows). The expression of these two markers in the trigeminal placodes had extended in both an anterior and posterior direction (see white arrows) (H,I).
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SEBD @sebioldev.bsky.social · 19/07/2026
📣 New article by #SEBD member @marianros.bsky.social research group @csic.es and collaborators now out @currentbiology.bsky.social on the origin and evolution of dorsal determination mechanisms in vertebrate paired appendages: Current Biology www.cell.com/current-biol...
cell.com
The origin and evolution of dorsal determination mechanisms in vertebrate paired appendages
Limbs have distinct sidedness, with dorsal-ventral flexure allowing diverse movements that permit nuanced articulation and function. Hawkins et al. demonstrate that the genetic foundation of this patt...
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Vicki Metzis @vmetzis.bsky.social · 17/07/2026
How does an embryo generate the right cells in the right place? Delighted to share our latest findings on how neural crest cells acquire vagal or trunk identities Spoiler alert: The timing & combination of CDXs preconfigures cell identity & distinct HOX states www.biorxiv.org/content/10.6...
biorxiv.org
Temporally distinct CDX programmes preconfigure vagal and trunk neural crest
Neural crest cells (NCCs) are progenitor cells vital in establishing the head, heart, gut and peripheral nervous system of vertebrate embryos. Disruptions to NCC development underlie neurocristopathie...
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Igor Adameyko @adameykolab.bsky.social · 11/07/2026
For the neural crest nerds: we love looking into transcriptional programs in single NCC cells. However, selective ribosomal modifications refine gene expression programs at a different scale. Here is our story about modified ribosomes in neural crest fate selection: www.nature.com/articles/s41...
nature.com
Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage - Nature Communications
Neural crest cells differentiate into skeletogenic mesenchyme and neuro-glial lineages, thereby contributing to craniofacial formation. Here, single-cell analysis of cranial neural crest shows that sp...
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Alt-NIHscience4ALL @alt-nihscience4all.altgov.info · 08/07/2026
NIDCR invites comments for its strategic plan. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-DE-26-015: Inviting Comments and Suggestions on Topic Areas for the NIDCR Strategic Plan for Fiscal Years 2027-2031
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Inviting Comments and Suggestions on Topic Areas for the NIDCR Strategic Plan for Fiscal Years 2027-2031 NOT-DE-26-015....
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MwahahahahahadScientist @mads100tist.bsky.social · 29/06/2026
Where Igor Ademeyko @adameykolab.bsky.social walks us through a beautiful scenario of what the hell neural crest cells are, co-option, and the camouflage hypothesis. With special mention of Rohon-Beard neurons! 🧪🐟
science.org
Co-option and innovation in neural crest evolution
Neural crest evolution reassembled ancient programs in pigment cell lineage, resulting in vertebrate innovations.
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Society for Developmental Biology @socdevbio.bsky.social · 12/06/2026
For this #FluorescenceFriday we have something a bit different. An SEM image of a sterlet sturgeon neurula embryo labelled with SOX9 which decorates the cranial neural crest - a transient embryonic tissue that shapes vertebrate faces. 🔬 #DevelopmentalBiology 📸: Jan Štundl
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Sierra Marable, PhD @smarable.bsky.social · 10/06/2026
So excited to be a part of this amazing community!
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Edward Elderman @elderman.bsky.social · 07/06/2026
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Ali Shaib @alishaib.bsky.social · 01/06/2026
Hello #world, meet 1,000× Expansion Microscopy. A small gel would grow to the size of an Olympic swimming pool, while amino-acid-scale distances become visible with ordinary light microscopy. Led by Helena Hu from @eboyden3.bsky.social's lab, in collab with us. Story: www.biorxiv.org/content/10.6...
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Sébastien Gauvrit @sebgauvrit.bsky.social · 29/05/2026
If you are looking for a useful free app for your lab, check this apps.apple.com/us/app/cell-... Developed by Umut Tank, a PhD student in Germany as a fun side project!
apps.apple.com
Cell Culture and Lab Assistant App - App Store
Download Cell Culture and Lab Assistant by Umut Tank on the App Store. See screenshots, ratings and reviews, user tips, and more apps like Cell Culture and Lab…
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dayyapparaja.bsky.social @dayyapparaja.bsky.social · 30/05/2026
Spatiotemporal development of human meninges !!! www.cell.com/cell/abstrac...
cell.com
Decoding the spatiotemporal development of human meninges
A spatiotemporal atlas of the human meninges during early-to-mid gestation identifies asynchronous layer development and transcriptomic features of meningeal cells and demonstrates that pial fibroblas...
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🍁 Bryan Heit, PhD 🍁 @bryanheit.bsky.social · 28/05/2026
#Macrophages have already been crowned as the best cell, and as amazing as they are, they only get better. Pigeon macrophages are literally magnetic, and enable the pigeon equivalent to GPS! www.science.org/doi/10.1126/...
science.org
Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditions
Birds use a variety of navigational strategies, including the geomagnetic field, especially when other cues are not available, such as under overcast or nocturnal conditions. Magnetite particles in th...
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James Gagnon @james-gagnon.bsky.social · 28/05/2026
Excited to share the published version of MIC-Drop-seq @natcomms.nature.com! Shoutout to co-lead authors @claycarey.bsky.social @sparvez.bsky.social for driving this work. Excited to see where this new scale of single-cell perturbation screening goes next. www.nature.com/articles/s41...
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Thiago Carvalho @cyrilpedia.bsky.social · 23/05/2026
'We primarily do comparative analysis using human stem cells/organoids and genetically modified mouse models, with some minor use of frog models. We use this approach because, for developmental anomalies, it is impossible to assess true function without in vivo models' @karenjliu.bsky.social
journals.biologists.com
Why in vivo models of disease remain indispensable
Summary: The call to arms for alternatives to model organisms of disease will fail without ongoing integration with – and validation against – complex animal models and support from the animal modelli...
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Dr Kathleen Millen @neurodevkathy.bsky.social · 20/05/2026
🚨🧪🧵URGENT INPUT NEEDED: NIH asks input for next strategic plan-including emphasis on non-animal models (NAMs) to replace animals. Per NIH insider, anti-animal responses now outnumber scientists 200-700x. Please please provide input. Deadline: May 26, 11:59 PM ET. grants.nih.gov/news-events/...
grants.nih.gov
NIH Seeks Input on Framework for Next NIH-Wide Strategic Plan | Grants & Funding
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Elena Vasileva @evasileva.bsky.social · 19/05/2026
Our lab website is live! 🚀🐟 www.vasilevalab.com We use genetic #zebrafish models and molecular oncology approaches to study pediatric cancer and discover new therapeutic strategies. We’re growing and recruiting postdocs and research technicians! #PediatricCancer #Zebrafish #PostdocJobs
vasilevalab.com
Home | Vasileva Lab
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Melissa Cooper, PhD @melcooperphd.bsky.social · 22/04/2026
Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!
nature.com
Astrocytes connect specific brain regions through plastic networks - Nature
Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.
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Pedro Hernandez @zebragut.bsky.social · 03/04/2026
Very happy to share this study from our group and colleagues now out in Science! We found that in zebrafish, before the immune system is mature, gut epithelial cells perform immune functions by producing the cytokine IL-22 to shape the microbiota to promote early life gut function #Zebrafish #Gut
science.org
IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota
The gut microbiota, immune system, and enteric nervous system interact to regulate adult gut physiology. However, the mechanisms establishing gut physiology during development remain unknown. We repor...
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Siegenthaler Lab @siegenthalerlab.bsky.social · 06/03/2026
🚨 New preprint from our lab led by Sophia Kim w/ @kellydoran.bsky.social group @cuanschutz.bsky.social -- using neonatal 🐭 model of bacterial meningitis ➡️ arachnoid barrier is leaky, Cldn11 junctions are disrupted & cytokines are part of the problem. Lots of 🤩🧠🦠🔬 & compelling data, check it out! 1/5
graphical schematic of the meninges on top depicting the three layers [dura, arachnoid and pia] and other immune and vascular cell types. Inset shows Claudin-11 junction proteins connecting two sides of arachnoid barrier cells

bottom schematic is the same but in inflammation with bacteria, junctions breakdown, depiction of cytokine release by vascular, meningeal and immune cells - at side of graphic is summary of defects we observe in infection: 'increased barrier permeability' 'mislocalization of Cldn11+ tight junction' 'BAM activation' and "increased inflammatory response'
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Siegenthaler Lab @siegenthalerlab.bsky.social · 06/03/2026
#FreehandFigureFriday continues...this from a figure I mocked up for a review but ended up on the 'digital' cutting room floor - scanning EM of the meninges of large mammals like dogs (this from PMID: 1094039) is really great, gives a great appreciate for 'smoothness' of SAS surfaces.
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Addgene @addgene.bsky.social · 23/02/2026
Check out the plasmids for pIGLET, a reproducible and efficient approach to generate zebrafish transgenic lines using site-specific recombination!
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Zebrafish Rock! @zebrafishrock.bsky.social · 23/02/2026
Collaborative work from @kendalllab.bsky.social 🐟 🔗 to preprint: www.biorxiv.org/content/10.6...
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Crystal Rogers, PhD @rogerslabucd.bsky.social · 22/02/2026
Excited to share this collaborative work with @sarathomasy.bsky.social- spearheaded by Raneesh Ramarapu and William Stoehr- where we visualized the unique spatial localization of tubulin isotopes in neural crest-derived corneal tissues during development. 🤩
A transverse section through a developing chicken eye after immunohistochemistry for tubulin proteins and with nuclear stain
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Zebrafish Rock! @zebrafishrock.bsky.social · 18/02/2026
Big congrats to Dr. Len Zon for being awarded the 2026 @marchofdimes.org Richard B Johnston Jr, MD Prize for his work in #devbio. His pioneering research has illuminated how blood develops in embryos, leading to a deeper understanding of genetic blood diseases. www.marchofdimes.org/about/news/r... 🧪
marchofdimes.org
Renowned Developmental Biologist Wins March of Dimes Prize
March of Dimes names Dr. Leonard Zon winner of the 2026 Richard B. Johnston Jr., MD Prize for breakthroughs in developmental biology and treatments for blood disorders.
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shaharbrr.bsky.social @handle.invalid · 06/02/2026
New preprint out! www.biorxiv.org/content/10.6... One of the most salient lessons I learned in all my adventures with screening and protein engineering is the importance of context. The context in which you test a gene or protein determines what function it has.
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Ben Hogan @benjhogan.bsky.social · 21/01/2026
We’re delighted to see this out today! Latest work from the lab reveals insights into the evolution of brain immunity and the developmental and evolutionary plasticity of lymphatic endothelial cells. www.nature.com/articles/s41...
nature.com
Convergent evolution of scavenger cell development at brain borders - Nature
Transcription factor osr2 is identified as a specific marker and regulator of mural lymphatic endothelial cell (muLEC) differentiation and maintenance, and muLECs and border-associated macrophages sha...
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Jeremy Reiter @reitergroup.bsky.social · 31/12/2025
Modern biology research is biased towards investigating genes that are widely conserved and present in humans. What about genes that ARE widely conserved but NOT present in humans? Can genes missing from humans tell us something about what makes our biology different from that of other animals? 1/8
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bioRxivpreprint @biorxivpreprint.bsky.social · 20/12/2025
Developmental regulation of intestinal best4+ cells www.biorxiv.org/content/10.64898/20…
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Zebrafish Rock! @zebrafishrock.bsky.social · 13/12/2025
“Here, we introduce the mini-golden system, a versatile Golden Gate-based subcloning platform that enables rapid assembly of donor constructs containing homology arms and a gene of interest.” Updated approach from the lab of Junsu Kang at University of Wisconsin-Madison 🐟
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Dr Zeinab Rekad 🔬🧬🧪 @zeinabrekad.bsky.social · 13/12/2025
Woow wooww, just wowwww! 🤯🤯🤯🤯🤯🤯 That is a very important reminder indeed! 👇🏻
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Zebrafish Rock! @zebrafishrock.bsky.social · 20/11/2025
#KnowYourZDM: In 2019, a 10-year-old patient w/ a life-threatening lymphatic disorder was losing hope. Zebrafish to the rescue! Scientists created zebrafish with the same gene mutation and found a melanoma drug that fixed the fish. Then, doctors used the same drug on the patient to save his life! 🧪
Zebrafish are an excellent model for studying the development and function of blood and lymphatic vessels. Research in zebrafish has even led to treatments for lymphatic disorders in people. This image, taken using a powerful microscope that uses lasers to illuminate the fish, shows blood vessels (magenta) and lymphatic vessels (green) in the eye and head of an anesthetized, 6-week-old, transgenic zebrafish.

Credit: Daniel Castranova, National Institute of Child Health and Human Development, NIH
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 17/11/2025
Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish www.biorxiv.org/content/10.1101/202…
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Valerie Tornini @valetornini.bsky.social · 03/11/2025
What cell states are possible when they are missing key factors - Nanog, Pou5f3 (Oct4), & Sox19b (Sox2) - that are required for the first embryonic reprogramming steps? Follow along with our latest publication, finally out at doi.org/10.1016/j.ce... #devbio #reprogramming #zebrafish #embryo (1/6)
Graphical abstract describing the main findings. Top, Nanog, Pou5f3, and Sox19b (NPS) work together for cellular reprogramming following fertilization of the egg and sperm in the embryo's maternal-to-zygotic transition. Clearance of the maternal program, plus activation of the zygotic and late zygotic genes expression programs later in development, together will enable gene expression programs towards cellular differentiation.
In maternal-zygotic NPS (mzNPS) mutant embryos, there is a failure of reprogramming and subsequently no gastrulation. However, when mzNPS embryonic cells are transplanted into wild type embryos, some cells survive and form mixed cell states, likely due to failed nuclear and cytoplasmic reprogramming. We find that some gene expression states, including primordial germ cell-like and motoneuron-like cell states, are able to develop in vivo, bypassing the loss of NPS-mediated embryonic reprogramming.
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Alex Eve @amjeve.uk · 17/10/2025
Compared to other publishers, The Company of Biologists is small fry with fewer than 70 staff supporting 5 journals from a single office. But, for over 100 years now, it’s punched above its weight in innovation, prestige and community support.
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Elena Vasileva @evasileva.bsky.social · 09/10/2025
1/9 Thrilled to share that our paper, “Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm,” is now published in @cp-cellreports.bsky.social! @amatrudalab.bsky.social @crumplab.bsky.social www.cell.com/cell-reports...
cell.com
Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm
Using a zebrafish genetic model of Ewing sarcoma, Vasileva et al. provide evidence for a neural crest origin of the disease. These findings offer new insight into how a single oncogenic fusion can hij...
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Crump Lab @crumplab.bsky.social · 10/10/2025
Wonderful collaboration of Claire Arata and co-first-author Elena Vasileva from Amatruda lab. Claire provided the neural crest driver and Elena the EWS oncofusion. Best combination since PB&J. Amazing that expression of a single oncofusion in crest produces ectopic fins. www.cell.com/cell-reports...
cell.com
Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm
Using a zebrafish genetic model of Ewing sarcoma, Vasileva et al. provide evidence for a neural crest origin of the disease. These findings offer new insight into how a single oncogenic fusion can hij...
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Natasha O'Brown @natashaobrown.bsky.social · 03/10/2025
We are looking for a new technician to join our lab and gain some hands on #zebrafish and molecular biology experience. Interested parties should apply here: jobs.rutgers.edu/postings/259... Happy to answer any and all questions about the lab! #STEMJobs
jobs.rutgers.edu
Laboratory/Technical Assistant
Rutgers, The State University of New Jersey is seeking a Laboratory/Technical Assistant for the Department of Cell Biology and Neuroscience within the School of Arts and Sciences. Our mission is to un...
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Christian Mosimann @chrmosimann.bsky.social · 30/09/2025
Out @natcomms.nature.com: our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀 Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!). Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social rdcu.be/eIJm5
nature.com
The pericardium forms as a distinct structure during heart formation - Nature Communications
The developing heart integrates several progenitor cell types. Here they show that the pericardium enveloping the heart develops among cells that form the mesothelium around inner organs and body cavities, distinct from the classic heart field.
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James Briscoe @jamesbriscoe.bsky.social · 29/09/2025
Nice work from Val Wilson & co on neuromesodermal progenitors SOX2/TBXT co-expressing cells are self-propagating bipotent NMPs Increasing TBXT levels (not SOX2/TBXT ratio) switch NMPs from neural- to mesoderm-biased www.biorxiv.org/content/10.1...
biorxiv.org
Brachyury expression levels predict lineage potential and axis-forming ability of in vitro derived neuromesodermal progenitors
Neuromesodermal progenitors (NMPs) produce the spinal cord and musculoskeleton in the elongating anterior-posterior axis. In vivo, NMPs possess dual potency, coinciding with regions coexpressing SOX2 ...
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American Society for Cell Biology @ascbiology.bsky.social · 29/09/2025
According to news reports, NIH is on track to award nearly all of its FY25 budget. Program officers—working long hours despite staff losses—made it possible. Take a moment to thank your PO for their dedication.
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Saxena Lab @saxenalab.bsky.social · 09/09/2025
Thank you @stemcellreports.bsky.social for featuring our work on the Neural Stem Cells Special Issue cover! www.cell.com/stem-cell-re... Kudos to lead author Sriivatsan G. Rajan for designing the image. Check out the wide array of interesting papers in this packed issue: www.cell.com/stem-cell-re...
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Development @dev-journal.bsky.social · 04/09/2025
Our next #DevPres webinar focusses on gut development with talks from Surojit Sural @surojitsural.bsky.social, Swarnabh Bhattacharya @iamzico.bsky.social and Brittany Edens, chaired by Alex Eve @amjeve.bsky.social. 📆 17 September, 15:00 BST (UTC+1) Register here: us02web.zoom.us/webinar/regi...
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Jan Stundl @janstundl.bsky.social · 13/08/2025
Excited to announce that our new paper is now published in Science Advances 🚀🧠 ‘Acquisition of neural crest promoted thyroid evolution from chordate endostyle’ — check it out here: www.science.org/doi/10.1126/...
science.org
Acquisition of neural crest promoted thyroid evolution from chordate endostyle
Integration of neural crest cells into the endostyle developmental program promoted its evolution into the thyroid gland.
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Ardem Patapoutian @ardemp.bskyverified.social · 13/08/2025
Over 20 years after Julius’s lab and mine cloned TRPM8, it is rewarding to see this science helping patients. The TRPM8 agonist Tryptyr treats dry eye by increasing tear production. A reminder that NIH-funded curiosity-driven research translates to medicines. tryptyr.myalcon.com?gad_source=1...
tryptyr.myalcon.com
TRYPTYR (acoltremon ophthalmic solution) 0.003% eye drops | Alcon US
TRYPTYR is a prescription eye drop used for the treatment of the signs and symptoms of dry eye disease. See prescribing information, how to save, and more.
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I-75 Scientist @flscitriguy.bsky.social · 17/07/2025
grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-25-132: Supporting Fairness and Originality in NIH Research Applications
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supporting Fairness and Originality in NIH Research Applications NOT-OD-25-132. NIH
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Nature Portfolio @natureportfolio.nature.com · 09/07/2025
It’s been 25 years since the UCSC Genome Browser launched. Nature profiles how the website remains an essential tool for navigating the genome and understanding its structure, function, and clinical impact. #Academicsky 🧬 🧪
go.nature.com
’We couldn’t live without it’: the UCSC Genome Browser turns 25
After a quarter of a century, the website remains an essential tool for navigating the genome and understanding its structure, function and clinical impact.
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