Technological advances over the past decade have enabled genome-wide mapping of chromatin organization across diverse organisms at unprecedented resolution. These studies have uncovered both conserve…

Cyclic oligonucleotide–based antiphage signaling systems (CBASS) are bacterial immune pathways evolutionarily related to cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes) in humans. ...

This now-extinct tongue was probably spoken somewhere in Eurasia as many as 8,000 years ago. But how do we know Proto-Indo-European must have existed?

Senior Downing Street officials reach out to thinktanks and pollsters as they look to test backing for reversing Brexit Senior Downing Street officials have been reaching out to thinktanks and pollsters as they look to test public support for the UK rejoining the EU. Aides to Andy Burnham have been talking to EU experts in a range of organisations about how the public would view a promise to rejoin, as momentum builds behind including such a pledge in the next Labour manifesto. Continue reading...

Anoxic live-cell imaging shows actin-dependent crawling motility and dynamic protrusions in Asgard archaea, providing insights into cellular innovations that may have contributed to eukaryotic evoluti...

To misquote Douglas Hofstadter: the backlash against AI in the research system will be bigger than you’re expecting, even once you take into account that it…

Saturn’s icy moon Enceladus features chemical signatures consistent with an alkaline soda ocean with H2 production via hydrothermal water-rock reactions. Chemolithoautotrophic methanogenesis is thermo...

Donate to the Wikimedia Foundation, the nonprofit that hosts Wikipedia and other crucial free knowledge projects. Each year, the generosity of the 2% of readers who donate allows us to expand the reac...

Nature Microbiology, Published online: 25 September 2026; doi:10.1038/s41564-026-02455-8HIDEN-SEQ (hidden Acr-enabled transposon-insertion sequencing) is a transposon-insertion sequencing method for phages that systematically links their genes to selectable phenotypes.

Symbiotic relationships of microorganisms are predicted and cataloged with a machine learning tool.

Identifying antiphage defense systems is challenging for bacterial species where such systems are understudied. This study describes a bioinformatic pipeline that uses a small serine recombinase as a ...

Using bioinformatics, biochemistry, NMR, as well as the newly characterized enzyme ArmA from methanogenic archaea, we revised the existing knowledge on archaeal peptidoglycan structure. At the same ti...

Active chromatin is usually described as open and accessible. Our live-cell imaging shows instead that euchromatin forms condensed domains, and that cohesin helps keep neighboring domains from mixing.

AbstractMotivation. The increasing number of fully sequenced bacterial plasmids being annotated and catalogued has prompted the development of computationa

Author summary Archaea are the least-studied of the three domains of life, yet they matter enormously: they flourish in extreme environments, drive global nutrient cycles, and are closely tied to the ...

Cohesin-mediated loop extrusion limits sister-fork coupling and tethers nearby replication forks under replication stress, promoting fork reversal and slowing fork progression to safeguard genome...

Compartmentalisation enables cells to spatially organise essential biochemical processes. This is exemplified by the eukaryotic nucleolus, which concentrates the machinery for ribosome biogenesis. Bac...

Prime minister Mark Carney calls for closer ties between Canada and Europe in both research and education

Dive into the sneaky world of superbugs and see how the MORF platform helps crack the code on ESKAPE pathogens' escape tricks.

Researchers are racing to culture a menagerie of exotic organisms and finding lots of surprises along the way.

Viruses are ubiquitous mobile genetic elements that are obligate symbionts of cellular life forms and replicate exclusively within host cells. The ...

While the dynamic changes in genome organization in cellular organisms have been well described, the three-dimensional (3D) folding of phage genomes during the infection of their host is extremely lim...

Abstract. When environmental bacteria transition to laboratory conditions, a process termed domestication, the shift from the native habitat to a culture m

Contribute to leepusp/ppigfinder development by creating an account on GitHub.

Nature Reviews Molecular Cell Biology, Published online: 24 August 2026; doi:10.1038/s41580-026-01018-3This Comment discusses the uses of Cas-induced homology-directed repair in the evolving landscape of highly specialized genome editing tools.

A genomic screen reveals homologues of ESCRT components in mirusviruses that infect unicellular aquatic eukaryotes.