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Centre for Structural Systems Biology CSSB

@cssbhamburg.bsky.social
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RAPP OptoElectronic @rappopto.bsky.social · 01/10/2026
🔬 High-res 3D imaging without labels: #holotomography uses refractive index as intrinsic contrast for quantitative imaging of living samples. Next week at @cssbhamburg.bsky.social , we’ll demo the @tomocube.bsky.social HT-X1™ Plus hands-on with participant samples. Book your spot: shorturl.at/Pu2U3
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SPC Facility & Garcia-Alai Lab @spcembl.bsky.social · 30/09/2026
🔥 New from our group in Protein Science! We introduce CheMelt, a tool for analyzing thermal & chemical protein denaturation, integrated into the EMBL Hamburg eSPC platform. 📖 Read the paper: onlinelibrary.wiley.com/doi/10.1002/... @embl.org @cssbhamburg.bsky.social @au.dk #Biophysics #CheMelt
onlinelibrary.wiley.com
Global analysis of thermal and chemical denaturation using <fc>CheMelt</fc>: Thermodynamic dissection of highly thermostable de novo designed proteins
De novo protein design often produces thermostable proteins that denature above 100°C, which complicates the analysis of their stability. Thermostable proteins can be unfolded by combined chemical an...
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 30/09/2026
During their 2-day visit, our SAB members learned about the latest developments at CSSB, met our newest group leader, and exchanged ideas with postdocs and PhD students during our poster session. Thank you to all our SAB members for your engagement! @thamlab.bsky.social @oneyrolles.bsky.social
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SPC Facility & Garcia-Alai Lab @spcembl.bsky.social · 28/09/2026
What brings clathrin adaptors, phase separation & membrane trafficking together? 🧬🔬 Our new paper in Communications Biology explores just that! Discover how clathrin adaptors drive LLPS during endocytosis—and what we found 👇 www.nature.com/articles/s42... @embl.org @cssbhamburg.bsky.social
nature.com
Clathrin adaptors drive phase separation in endocytosis and trafficking - Communications Biology
Communications Biology - Clathrin adaptors drive phase separation in endocytosis and trafficking
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 25/09/2026
What role do membrane contact sites play in bacterial pathogenesis and infection? To explore this question, 24 PIs from across Germany, representing two scientific communities - lipid biology and infection biology - came together at CSSB. More info:https://t1p.de/xe7u0 @carobarisch.bsky.social
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 09/09/2026
The MHH Virology Retreat took place at CSSB last week. Participants had a great time getting to know CSSB and sharing their latest research. Thanks to all who attended! @bosse-lab.bsky.social
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 07/09/2026
Researchers from CSSB and the @uwmadison.bsky.social have discovered that a layer of cellular energy regulation lies in proteoforms — unique chemical variants of proteins. A new study reveals how these proteoforms arise through the activity of AMPK. More Information: t1p.de/orr75
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Reposted by Centre for Structural Systems Biology CSSB
Helmholtz-Zentrum für Infektionsforschung (HZI) @helmholtzhzi.bsky.social · 07/09/2026
P. aeruginosa kann viele verschiedene Gewebe infizieren. HZI-Forscher Michael Kolbe am @cssbhamburg.bsky.social hat nun mit Kolleg:innen Proteine des Bakteriums strukturbiologisch untersucht & konnte zeigen, wie sie Poren in der Zellmembran des Wirts verursachen. www.helmholtz-hzi.de/media-center...
helmholtz-hzi.de
Entdeckung eines molekularen Virulenzmechanismus von P. aeruginosa
Forschende des CSSB untersuchen Phospholipasen von Pseudomonas aeruginosa und decken molekulare Virulenzmechanismen für Infektion und Erkrankungen auf.
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 04/09/2026
Congratulations to @deep-dv-for5200.bsky.social social for receiving the 2026 North German Science Award! Congrats to all the scientist who are part of the DEEP-DV team including CSSB group leader Jens Bosse @bosse-lab.bsky.social .
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 04/09/2026
Researchers from CSSB's Kolbe group (@uni-hamburg.de, @helmholtzhzi.bsky.social), along with collaborators from Research Center Jülich, EMBL Hamburg, DESY and BIOTECH Thailand have uncovered novel virulence mechansims of phospholipase C from P. aeruginosa. More info: t1p.de/sbjpq
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 26/08/2026
The NordInfect Symposium is in full swing at CSSB! The symposium brings together the bacteriology community from Northern Germany for a one-day event highlighting a broad range of cutting-edge research. NordInfect website: nordinfect.cssb-hamburg.de @carobarisch.bsky.social @itzenlab.bsky.social
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 13/08/2026
Researchers from CSSB in collaboration with the NCBI traced the lineage of two bacterial enzymes. By reconstructing their common ancestral protein, the team uncovered novel insights into the molecular mechanisms of these nucleases. More: t1p.de/mf3qk @uni-kiel.de @holgersondermann.bsky.social
IMAGE: Holger Sondermann, Biorender
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EMBL @embl.org · 20/07/2026
@cssbhamburg.bsky.social
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Reposted by Centre for Structural Systems Biology CSSB
Leibniz-Institut für Virologie (LIV) @leibnizliv.bsky.social · 22/06/2026
🔬 Just a few days to go until the 28th International Workshop on Kaposi’s Sarcoma Herpesvirus (KSHV) & Related Agents (28 June – 1 July 2026, @cssbhamburg.bsky.social Hamburg). On-site registration is available. More info about the event: leibniz-liv.pulse.ly/wxetp8mn26 @ksvirus.org
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 10/06/2026
Thanks to everyone who joined us on Monday for the panel discussion "Coding Life" hosted by @adwhamburg.bsky.social & CSSB. Our experts had a lively discussion about the use of AI in in synthetic biology and medicine as well as its impact on the future of scientific research. @bosse-lab.bsky.social
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 05/06/2026
🧬🤖 Kann man Leben programmieren? Und wo sollten wir Grenzen ziehen? Bei Coding Life diskutieren Expert:innen über synthetische Biologie, KI und die Zukunft des Lebens. 📅 08.06.2026 | 📍 Hamburg 👉 www.cssb-hamburg.de/codinglife
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Instruct-ERIC @instruct-eric.bsky.social · 30/05/2026
First international VISION symposium on Integrated Structural Virology 📅 8 – 9 September 2026 📍 @cssbhamburg.bsky.social , Hamburg, Germany 📝 Registration Open| Deadline: 19 July 2026 🔗
instruct-eric.org
First international VISION symposium on Integrated Structural Virology
<p>The DFG Research Training Group 2887 “VISION - Visualization and Imaging in Viral Infection” is excited to invite you to the first <strong>international VISION symposium on Integrated Structural…
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Instruct-ERIC @instruct-eric.bsky.social · 28/05/2026
More great talks this afternoon at the Instruct-ERIC Biennial conference, as well as two poster sessions. We had speakers from @helmholtzmunich.bsky.social , ThermoFisher, @viblifesciences.bsky.social , @psi.ch , @cssbhamburg.bsky.social , and @eu-openscreen.bsky.social
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 28/05/2026
Am Montag, dem 8. Juni, um 19:00 Uhr laden das @cssbhamburg.bsky.social und @adwhamburg.bsky.social zu einer Podiumsdiskussion zum Thema „Coding Life: Das Leben mit KI und biologischen Werkzeugen gestalten“ ein. Anmeldung: lnkd.in/dCnygtGX @bosse-lab.bsky.social @landaulabcssb.bsky.social
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SPC Facility & Garcia-Alai Lab @spcembl.bsky.social · 28/05/2026
Excited to be attending the Biennial Conference of Instruct-ERIC in Brussels. @instruct-eric.bsky.social Looking forward to engaging discussions on structural biology, research infrastructures, technology development, and scientific collaboration across Europe. @embl.org @cssbhamburg.bsky.social
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Instruct-ERIC @instruct-eric.bsky.social · 21/05/2026
Speakers for Session 2: New Technologies at our Biennial Conference in Brussels, 28-29 May 2026 You can see the full agenda and find out more information about the talks on our website: instruct-eric.org/ibsbc2026-sp...
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 21/05/2026
Join us for the Nordinfect Symposium on August 26th at the CSSB in Hamburg. This meeting will bring together the Northern German bacteriology community for a day of cutting-edge science and networking. More information and registration: lnkd.in/ev5F3Rbm @uni-hamburg.de @fzborstel.bsky.social
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Akademie der Wissenschaften in Hamburg @adwhamburg.bsky.social · 18/05/2026
Was wäre, wenn wir das Leben nicht nur verstehen, sondern auch aktiv programmieren? #Podiumsdiskussion zu „Coding Life“ am 8. Juni 2026. Eintritt frei. Anmeldung unter 👉 indico.desy.de/event/53406// Zur PM 👉 www.awhamburg.de/aktuell/pres... @cssbhamburg.bsky.social @bosse-lab.bsky.social
Veranstaltungshinweis "Coding Life - Leben gestalten mit biologischen Werkzeugen" am 8. Juni 2026
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 08/05/2026
On June 8 at 19:00, CSSB together with @adwhamburg.bsky.social will be hosting a panel discussion entitled “Coding Life: Leben gestalten mit biologischen Werkzeugen.” Registration: www.cssb-hamburg.de/codinglife @bosse-lab.bsky.social @uni-hamburg.de @leibnizliv.bsky.social @embl.org
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Leibniz-Institut für Virologie (LIV) @leibnizliv.bsky.social · 27/04/2026
28th International Workshop from @ksvirus.org is coming to Hamburg. Can't wait to welcome you to our harbour city. We are very excited for the scientific discussion and exchange at @cssbhamburg.bsky.social. Register here: ksvirus.pulse.ly/ioh7jdxmmg
ksvirus.pulse.ly
Registration - Kaposi’s Sarcoma Herpesvirus (KSHV)
Online Meeting Registration Form
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 27/04/2026
Last week, CSSB and EMBL Hamburg hosted students from the Business Academy Aarhus in Denmark. The group of students learned about the life science research conducted at both institutions. @amyloid-sam.bsky.social @embl.org
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KaufmannLab @kaufmannlab.bsky.social · 24/04/2026
Happy to see the preprint of our VULCROM setup online! Thanks to our amazing collaborators we've managed to get some pretty cool cryo-CLEM images by combining cryo super-resolution and cryo-ET: doi.org/10.64898/202...
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 24/04/2026
28 children spent the day at CSSB for Girls' and Boys' Day yesterday! The kids built microscopes, conducted chemistry and chromatography experiments, tried VR goggles@ and much more. @landaulabcssb.bsky.social @topf-lab.bsky.social @kaufmannlab.bsky.social
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VIB-KU Leuven Center for Neuroscience @vibneuroleuven.bsky.social · 22/04/2026
🧪 3rd Leuven Protein Aggregation Meeting | 9–11 Sep 2026 📍 Great Beguinage of Leuven Our illustrious speakers list also includes @meytallandau.bsky.social (@cssbhamburg.bsky.social) & @ruferbus.bsky.social (@uni-goettingen.de). Don't miss it! More info: vibbio.tech/ProAgg26 #ProAgg26
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 21/04/2026
CSSB’s first flagship project “PLASMOFRACTION” has successfully deciphered membrane protein complexes in the malaria parasite Plasmodium falciparum. Find out more: t1p.de/wthx2 @jankosinski.bsky.social, @embl.org, @uni-hamburg.de, @unituebingen.bsky.social, @fmp-berlin.de
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SPC Facility & Garcia-Alai Lab @spcembl.bsky.social · 10/04/2026
New preprint out 🚀 De novo designed proteins are often too stable — but why? Using CheMelt, we show that their exceptional thermostability is largely driven by unusually low heat capacity changes (ΔCp). 👉 www.biorxiv.org/content/10.6... @embl.org @osvalb.bsky.social @proteinmagnus.bsky.social
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 31/03/2026
Last Friday, the President of the Hannover Medical School , Prof. Denise Hilfiker-Kleiner, together with the Vice President of @uni-hamburg.de Prof. Tilo Böhmann visited CSSB. The visit included tours of PETRA III beamlines as well as CSSB’s four core facilities. @bosse-lab.bsky.social
Photo: O. Jaeckle-TietjenPhoto: O. Jaeckle-TietjenPhoto: O. Jaeckle-Tietjen
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 24/03/2026
Congratulations!
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 23/03/2026
Check out the new @spidocs.bsky.social comic entitled Training the Next Generation SPIDoc‘s: A tale of laser beams and building teams designed by Véro Mischitz. @leibnizliv.bsky.social @europeanxfel.bsky.social @ebi.embl.org
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SPC Facility & Garcia-Alai Lab @spcembl.bsky.social · 18/03/2026
Very exciting demo on smFRET &FCCS measurements in our SPC facility this week with Exciting Instruments @ei-science.bsky.social ✨🧮 Thank you for allowing us to measure single molecule resolution using your technology. It has been again, very exciting 🔍🤩 @embl.org @cssbhamburg.bsky.social
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 12/03/2026
Congratulations to the @uni-hamburg.de for once again being awarded the University of Excellence title! 🎉
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Universität Hamburg @uni-hamburg.de · 11/03/2026
Universität Hamburg gewinnt Exzellenztitel erneut 👏 Damit erhält die UHH weiterhin als eine von wenigen Universitäten diese bedeutende Förderung. Künftig liegt der Fokus noch stärker auf der Twin Transformation, die Nachhaltigkeit und Digitalisierung als Querschnittsaufgabe verbindet: uhh.de/n87ie
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Fabio Strati @stratifa.bsky.social · 09/03/2026
Hello BlueSky Community, do you know of any European Cryo-EM facility which possess a High-pressure freezer being used under BSL-2 safety level? The sample would be a bacterial biofilm.
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 09/03/2026
Happy International Women's Day! #IWD2026 CSSB supports women in science and we pledge to elevate & celebrate women’s achievements. @carobarisch.bsky.social, @landaulabcssb.bsky.social @topf-lab.bsky.social, @mariarosenthal.bsky.social
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🌼 Gali 🌼 @gearaguirang.bsky.social · 23/02/2026
Today’s CSSB @cssbhamburg.bsky.social Seminar Series featured Paul Guichard @centriolelab.bsky.social from Geneva who shared their beautiful discoveries of the centriole assembly, conoid molecular architecture, and the connecting cilium of the eye! ♡ 🫧 @uni-hamburg.de
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Caro Barisch @carobarisch.bsky.social · 12/02/2026
Such a fun collaboration with @mel-foulon.bsky.social from the TS lab 🤝-👀 We combined dual RNA-Seq 🧬 and advanced imaging 🔬 to uncover how intracellular compartmentalization drives niche-specific metabolic phenotypes in mycobacteria!! Fantastic team effort ✨ #Tbsky #microsky
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SPIDoc's - MSCA Doctoral Network @spidocs.bsky.social · 19/02/2026
The year has just started, a lot already happened at SPIDocs! 🎉Charlotte Uetrecht - new Scientific Director @cssbhamburg.bsky.social 🚀Secondments at @uppsalauniversity.bsky.social and Fasmatech Science and Technology 🚀Internships at SLAC ✨Course 'Ion trap and advanced MS techniques' at MSVision
Course 'Ion trap and advanced MS techniques' - group picture at MS Vision
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 12/02/2026
New preprint from @carobarisch.bsky.social lab!
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 11/02/2026
@mariarosenthal.bsky.social #STEM #GirlsInScience
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 11/02/2026
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 11/02/2026
🎉 Happy International Day of Women and Girls in Science 🔬 Some of our group leaders shared insights into what they love most about their jobs in science. ❤️ CSSB supports women and girls in science through initiatives like Girls‘ and Boys‘ Day. #WomenInScience @landaulabcssb.bsky.social
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Instruct-ERIC @instruct-eric.bsky.social · 29/01/2026
Integrated structural biology at its best with fantastic talks in cryo-EM, NMR, and X-ray techniques Also integration with other Instruct Centres, in this case Kay Grünewald Instruct-DE @cssbhamburg.bsky.social 'Conformational flexibility and molecular plasticity in herpesvirus entry and egress'
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SPC Facility & Garcia-Alai Lab @spcembl.bsky.social · 29/01/2026
New protocol out now! 📕🖊️🔍 A practical workflow for analyzing CD thermal unfolding of short RNAs — from SVD decomposition to two-state fitting to extract melting temp and enthalpy with ChiraKit. A must-see if you’re working with RNA structure and CD data. DOI: 10.1007/978-1-0716-5084-4_12 
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Emil Gustavsson @emilgustavsson.bsky.social · 21/01/2026
My colleagues have put together a nice book chapter on amyloid polymorphism. Have a look! 🧪🧬🧶 #amyloids #cryoem @landaulabcssb.bsky.social @meytallandau.bsky.social @cssbhamburg.bsky.social @stratifa.bsky.social
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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 09/01/2026
Fun in the snow!
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