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Reposted by Bosse lab at CSSB Hamburg

Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 08/05/2026

On June 8 at 19:00, CSSB together with @adwhamburg.bsky.social will be hosting a panel discussion entitled “Coding Life: Leben gestalten mit biologischen Werkzeugen.” Registration: www.cssb-hamburg.de/codinglife @bosse-lab.bsky.social @uni-hamburg.de @leibnizliv.bsky.social @embl.org

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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 12/05/2026

Want to do a PhD combining cryo-EM, AI-driven binder design, and deep virology in a cutting-edge environment and in an international team? We're hiring @CSSB_Hamburg 🔬 You: curious, rigorous, MSc in biochem, biophysics, virology, related Interested? DM me. Please RT 🙏 #PhDposition #cryoEM #virology

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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 01/12/2025

Become my colleague at CSSB! Hannover Medical School is recruiting a W1 Professor in Systems Virology (m/f/d), based at CSSB Hamburg. Focus: system-wide analysis of virus–virus & virus–host interaction networks. tinyurl.com/msh2449a #Virology #SystemsVirology #AcademicJobs

tinyurl.com

W1 university professorship for Systems Virology - Region Hannover, Niedersachsen (DE) job with Hannover Medical School (MHH) | 12849342

Hannover Medical School (MHH) invites applications for a W1 university professorship for Systems Virology.

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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 28/11/2025

Do you want to image RNA in living cells? Check out our new live-cell Click labeling approach. An amazing collaboration with the Meier Lab at UHH and the Wagenknecht Lab at KIT! doi.org/10.1002/anie... Congratulations, especially to Doerte, Eileen, and Iven! Thanks to DFG CRC1648

doi.org

Live‐Cell RNA Imaging via Clickable TriPPPro Nucleotide Reporters

The intracellular delivery of trans-cyclooctene and bicyclo[6.1.0]nonyne as sterically demanding groups for the inverse electron-demand Diels–Alder was achieved by the triphosphate prodrug (TriPPPro)....

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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 26/08/2025

f you’re interested in our latest developments have a look at: Comparative Systems Virology Symposium: Jens Bosse youtu.be/PlAcAR1-IJA?si… via @YouTube Thanks to the @czbiohub for organizing and my amazing team for the great data!

youtu.be

Comparative Systems Virology Symposium: Jens Bosse

YouTube video by Chan Zuckerberg Biohub Network

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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 19/08/2025

A big thanks to Carolina Arias, Amy Kistler and Noam Stern-Ginossar for organizing an amazing meeting on comparative systems virology yesterday @czbiohub.bsky.social in San Francisco! www.czbiohub.org/events/front...

czbiohub.org

Frontiers in Comparative Systems Virology Symposium 2025

Be part of this exciting gathering to shape the future of comparative systems virology!

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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 26/06/2025

Are you interested in supporting a young international team of scientists as a part-time job? We have an open 25% team assistant position in our lab in Hamburg at the Centre for Structural Systems Biology (CSSB)! Please apply via: mhh.hr4you.org/job/view/327...

mhh.hr4you.org

Team Assistant (f/d/m)

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Reposted by Bosse lab at CSSB Hamburg

GfV - Gesellschaft für Virologie @gesvirologie.bsky.social · 05/03/2025

Congratulations to Thomas Mettenleiter for winning this year's Loeffler Frosch Medal awarded for his special service to virology as the long-term President of the Friedrich-Löffler Institut

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Reposted by Bosse lab at CSSB Hamburg

Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 04/03/2025

The third session of our symposium is Bacteria. The session begins on May 8 with a talk by Hinrich Schulenburg from @uni-kiel.de Register today: cssb-hamburg.de/symposium2025 @carobarisch.bsky.social @bosse-lab.bsky.social @topf-lab.bsky.social @landaulabcssb.bsky.social @jankosinski.bsky.social

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Reposted by Bosse lab at CSSB Hamburg

Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 25/02/2025

Check out this video summary of the first day of our upcoming symposium "Mechanisms of Infection - from structure to translation." Register by April 8: t1p.de/gztmj @bosse-lab.bsky.social, @carobarisch.bsky.social, @jankosinski.bsky.social, @meytallandau.bsky.social @topf-lab.bsky.social

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Reposted by Bosse lab at CSSB Hamburg

Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 14/02/2025

Alan Cowman from WEHI @wehi-research.bsky.social will give the second talk in our Parasites session on May 7. Register to attend by April 8: t1p.de/gztmj @carobarisch.bsky.social @bosse-lab.bsky.social @jankosinski.bsky.social @robinsonmeyer.bsky.social

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Reposted by Bosse lab at CSSB Hamburg

Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 19/02/2025

The fourth and final speaker in the Parasites session of our symposium is Ron Dzikowski from The Hebrew University of Jerusalem. Register for the symposium by April 8: t1p.de/gztmj @leibnizliv.bsky.social @fzborstel.bsky.social @uni-hamburg.de @embl.org @helmholtzhzi.bsky.social

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Reposted by Bosse lab at CSSB Hamburg

Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 18/02/2025

CSSB alumnus Michael Filarsky from @unituebingen.bsky.social will give a talk during our "Parasites" session on May 7. Take a look at the symposium programme here: t1p.de/h48ek @leibnizliv.bsky.social @fzborstel.bsky.social @helmholtzhzi.bsky.social @uni-hamburg.de

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Reposted by Bosse lab at CSSB Hamburg

Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 11/02/2025

The second session of our symposium is "Parasites". Emily Derbyshire's talk entitled "Interdisciplinary approaches to reveal parasite vulnerabilities" will start the session. Register by April 8: t1p.de/gztmj @meytallandau.bsky.social @carobarisch.bsky.social @bosse-lab.bsky.social

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Reposted by Bosse lab at CSSB Hamburg

Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 10/02/2025

On May 7, Ilaria Ferlenghi from GSK will give a talk entitled "Fast-Track to Immunity: The Fusion of Structural Biology, AI, and ML in Vaccine Innovation" Register today: t1p.de/gztmj @carobarisch.bsky.social @bosse-lab.bsky.social @jankosinski.bsky.social @meytallandau.bsky.social

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Reposted by Bosse lab at CSSB Hamburg

RTG2771 Humans and Microbes @rtg2771.bsky.social · 29/01/2025

🚨 Save the date! 🚨 We're thrilled to announce our International Symposium on Cell & Structural Biology of Host-Pathogen Interaction 📅 Sept 10-12, 2025 📍 @cssbhamburg.bsky.social Hamburg Registration starts soon For more info: humansandmicrobes2025.de

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Reposted by Bosse lab at CSSB Hamburg

Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 03/02/2025

Our symposium "Mechanisms of Infection: from structure to translation" will take place from May 7-8. Over the next weeks, we will be introducing our 15 confirmed speakers. Sriram Subramaniam from the University of British Columbia will be giving the key note. www.cssb-hamburg.de/symposium2025

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Reposted by Bosse lab at CSSB Hamburg

Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 04/02/2025

The first session of our symposium "Mechanisms of Infection: from structure to translation" is Viruses. Ben tenOever from New York University will give the first talk in this session. t1p.de/xu79k @carobarisch.bsky.social @bosse-lab.bsky.social @topf-lab.bsky.social @jankosinski.bsky.social

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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 04/02/2025

About 1,5 years ago I predicted in a little writeup for the ExC RESIST that ever more capable LLMs will soon make scientific review articles obsolete. From the initial results I have from #OpenAIs #DeepResearch, this is happening very soon…

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Reposted by Bosse lab at CSSB Hamburg

Melina Vallbracht @vallbracht.bsky.social · 07/01/2025

We are very excited that our in-situ structural analysis of the Ebola virus nucleocapsid assembly cascade is now published in @cellpress.bsky.social!

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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 17/12/2024

Join us in Hamburg, 7th-8th of May, at the CSSB! cssb-hamburg.de/symposium2025

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Reposted by Bosse lab at CSSB Hamburg

Torsten Schwede @torstenschwede.bsky.social · 03/12/2024

Conclusion of RNA assessors in #CASP16 - we are still in the “template” phase. Prediction of nucleic acids structure is still challenging for targets without templates, often relying on intuition. No big leap in accuracy since CASP15. AI based methods have not (yet?) made a major difference.

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Reposted by Bosse lab at CSSB Hamburg

Arne Elofsson @handle.invalid · 03/12/2024

Stone conclusion by hearsay from day 1 at #CASP16 all top methods used AF3 somehow. Improvements are made by increased sampling (FFT etc), ranking of models still a challenge. Some improvement on antibodies.

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Reposted by Bosse lab at CSSB Hamburg

Arne Elofsson @handle.invalid · 03/12/2024

Conclusions from RNA section at #CASP16, without a template all fail. All small targets had a template.

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Reposted by Bosse lab at CSSB Hamburg

Arne Elofsson @handle.invalid · 03/12/2024

Conclusion for ligand session in #casp16, without a template methods fail

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Reposted by Bosse lab at CSSB Hamburg

Torsten Schwede @torstenschwede.bsky.social · 02/12/2024

#CASP16: are we making progress in predicting protein-protein complexes?Not much in general, but …. One method (Kozakov Vajda) shows great improvement in predicting structure of antibody-antigen complexes. 🧪 🧬

Histogram of performance of antibody antigen structure prediction

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Reposted by Bosse lab at CSSB Hamburg

Torsten Schwede @torstenschwede.bsky.social · 02/12/2024

#CASP16 assessors’ summary of the protein complex category 🧪 🧬

Conclusion slide of oligomer prediction assessment

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Reposted by Bosse lab at CSSB Hamburg

Torsten Schwede @torstenschwede.bsky.social · 02/12/2024

Assessors’ conclusions of the 3D category (individual protein chains) of #CASP16 🧪

Conclusions of assessment of 3D category

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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 26/11/2024

Our Herpesfolds paper is out in Nature Communications! rdcu.be/d1uM7 Congrats to Timothy Soh, @sofiaaognibene , Saskia Sanders, Robin Schaeper and Benedikt Kaufer! Have a look at our database at herpesfolds.org by Malte Kansy

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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 23/11/2024

We ran a complete in-silico protein interaction screen of the monkeypox proteome using AlphaFold. Have a look at the interactive PPI network at www.poxfolds.org/poxppis.php All data is open source and can also be downloaded at zenodo

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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 18/11/2024

We made herpesfolds for all pox-virologists :-) poxfolds.org. Proteome-wide predictions of MPOX, VACV, and VARV in a handy cheat-sheet homology table, as well as structure-based clustering! MPOX all against all PPI predictions will follow soon! Thanks to Tim Soh and Malte Kansy

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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 18/11/2024

The new herpesfolds.org is online! We completely revamped the website and database for smoother browsing! Have a look at proteome-wide herpesvirus structural predictions and all possible protein-protein interactions! Thanks to Malte Kansy and Tim Soh!

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Reposted by Bosse lab at CSSB Hamburg

Jesse Erasmus @jesseerasmus.bsky.social · 10/11/2024

Couldn’t find a virology starter pack so here’s one to get the ball rolling. Repost/reply if you are a virologist so I can find and add you to the list! go.bsky.app/SinqoJU

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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 18/11/2024

Here's the virology starter pack! go.bsky.app/BAXfYom

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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 18/11/2024

Any virologists here? I would like to collect a starter pack. Please let me know if you would like to be included!

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Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 18/11/2024

We have two open PhD positions in the lab! One with the Landau Lab, which is on viral amyloids, and one is on phase separation of viral replication compartments! See v22.desy.de/e67416/recor... for viral amyloids, and PM me for the second. -We are looking for an individual with comp. methods exp.

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