iiinova — where your digital self keeps evolving

Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 30/09/2026

During their 2-day visit, our SAB members learned about the latest developments at CSSB, met our newest group leader, and exchanged ideas with postdocs and PhD students during our poster session. Thank you to all our SAB members for your engagement! @thamlab.bsky.social @oneyrolles.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 25/09/2026

What role do membrane contact sites play in bacterial pathogenesis and infection? To explore this question, 24 PIs from across Germany, representing two scientific communities - lipid biology and infection biology - came together at CSSB. More info:https://t1p.de/xe7u0 @carobarisch.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 09/09/2026

The MHH Virology Retreat took place at CSSB last week. Participants had a great time getting to know CSSB and sharing their latest research. Thanks to all who attended! @bosse-lab.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 07/09/2026

Researchers from CSSB and the @uwmadison.bsky.social have discovered that a layer of cellular energy regulation lies in proteoforms — unique chemical variants of proteins. A new study reveals how these proteoforms arise through the activity of AMPK. More Information: t1p.de/orr75

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 04/09/2026

Researchers from CSSB's Kolbe group (@uni-hamburg.de, @helmholtzhzi.bsky.social), along with collaborators from Research Center Jülich, EMBL Hamburg, DESY and BIOTECH Thailand have uncovered novel virulence mechansims of phospholipase C from P. aeruginosa. More info: t1p.de/sbjpq

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 26/08/2026

The NordInfect Symposium is in full swing at CSSB! The symposium brings together the bacteriology community from Northern Germany for a one-day event highlighting a broad range of cutting-edge research. NordInfect website: nordinfect.cssb-hamburg.de @carobarisch.bsky.social @itzenlab.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 13/08/2026

Researchers from CSSB in collaboration with the NCBI traced the lineage of two bacterial enzymes. By reconstructing their common ancestral protein, the team uncovered novel insights into the molecular mechanisms of these nucleases. More: t1p.de/mf3qk @uni-kiel.de @holgersondermann.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 10/06/2026

Thanks to everyone who joined us on Monday for the panel discussion "Coding Life" hosted by @adwhamburg.bsky.social & CSSB. Our experts had a lively discussion about the use of AI in in synthetic biology and medicine as well as its impact on the future of scientific research. @bosse-lab.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 05/06/2026

🧬🤖 Kann man Leben programmieren? Und wo sollten wir Grenzen ziehen? Bei Coding Life diskutieren Expert:innen über synthetische Biologie, KI und die Zukunft des Lebens. 📅 08.06.2026 | 📍 Hamburg 👉 www.cssb-hamburg.de/codinglife

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 28/05/2026

Am Montag, dem 8. Juni, um 19:00 Uhr laden das @cssbhamburg.bsky.social und @adwhamburg.bsky.social zu einer Podiumsdiskussion zum Thema „Coding Life: Das Leben mit KI und biologischen Werkzeugen gestalten“ ein. Anmeldung: lnkd.in/dCnygtGX @bosse-lab.bsky.social @landaulabcssb.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 21/05/2026

Join us for the Nordinfect Symposium on August 26th at the CSSB in Hamburg. This meeting will bring together the Northern German bacteriology community for a day of cutting-edge science and networking. More information and registration: lnkd.in/ev5F3Rbm @uni-hamburg.de @fzborstel.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 08/05/2026

On June 8 at 19:00, CSSB together with @adwhamburg.bsky.social will be hosting a panel discussion entitled “Coding Life: Leben gestalten mit biologischen Werkzeugen.” Registration: www.cssb-hamburg.de/codinglife @bosse-lab.bsky.social @uni-hamburg.de @leibnizliv.bsky.social @embl.org

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 27/04/2026

Last week, CSSB and EMBL Hamburg hosted students from the Business Academy Aarhus in Denmark. The group of students learned about the life science research conducted at both institutions. @amyloid-sam.bsky.social @embl.org

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 24/04/2026

28 children spent the day at CSSB for Girls' and Boys' Day yesterday! The kids built microscopes, conducted chemistry and chromatography experiments, tried VR goggles@ and much more. @landaulabcssb.bsky.social @topf-lab.bsky.social @kaufmannlab.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 21/04/2026

CSSB’s first flagship project “PLASMOFRACTION” has successfully deciphered membrane protein complexes in the malaria parasite Plasmodium falciparum. Find out more: t1p.de/wthx2 @jankosinski.bsky.social, @embl.org, @uni-hamburg.de, @unituebingen.bsky.social, @fmp-berlin.de

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 31/03/2026

Last Friday, the President of the Hannover Medical School , Prof. Denise Hilfiker-Kleiner, together with the Vice President of @uni-hamburg.de Prof. Tilo Böhmann visited CSSB. The visit included tours of PETRA III beamlines as well as CSSB’s four core facilities. @bosse-lab.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 23/03/2026

Check out the new @spidocs.bsky.social comic entitled Training the Next Generation SPIDoc‘s: A tale of laser beams and building teams designed by Véro Mischitz. @leibnizliv.bsky.social @europeanxfel.bsky.social @ebi.embl.org

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 09/03/2026

Happy International Women's Day! #IWD2026 CSSB supports women in science and we pledge to elevate & celebrate women’s achievements. @carobarisch.bsky.social, @landaulabcssb.bsky.social @topf-lab.bsky.social, @mariarosenthal.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 11/02/2026

🎉 Happy International Day of Women and Girls in Science 🔬 Some of our group leaders shared insights into what they love most about their jobs in science. ❤️ CSSB supports women and girls in science through initiatives like Girls‘ and Boys‘ Day. #WomenInScience @landaulabcssb.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 05/01/2026

New Year, New Leadership! Charlotte Uetrecht is the new Scientific Director of CSSB. Holger Sondermann and Tim Gilberger are Deputy Directors. Find out more: t1p.de/q6mdg @carobarisch.bsky.social @topf-lab.bsky.social @landaulabcssb.bsky.social @bosse-lab.bsky.social @jankosinski.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 16/12/2025

The 25th issue of our CSSB Connect newsletter is here! Find out what's been going on at CSSB during the second half of 2025. t1p.de/352cr @uni-hamburg.de @leibnizliv.bsky.social @fzborstel.bsky.social @helmholtzhzi.bsky.social @embl.org

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 12/12/2025

Our next CSSB Connect newsletter is coming out soon! Make sure it's delivered straight to your inbox by signing up today: t1p.de/hnamq @landaulabcssb.bsky.social @carobarisch.bsky.social @bosse-lab.bsky.social @topf-lab.bsky.social @jankosinski.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 03/12/2025

MHH invites applications for a W1 university professorship for Systems Virology at CSSB. The research focus should be on analyzing viral infections using innovative, systemwide methods to elucidate virus-virus and virus-host interaction networks. More info: t1p.de/nag2v @bosse-lab.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 01/12/2025

CSSB group leader Jens Bosse @bosse-lab.bsky.social @resist-cluster.bsky.social and CSSB associate member Chris Meier @uni-hamburg.de , together with Hans-Achim Wagenknecht from the Karlsruhe Institute of Technology, have developed a new method for live-cell RNA imaging Find out more: t1p.de/18suk

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 28/11/2025

Join CSSB! The Sondermann lab is interested in deciphering the molecular processes that determine bacterial interactions in microbial communities. They are looking for a PhD candidate to investigate the bacterial secretion systems involved in these processes. Apply now: v22.desy.de/e67416/recor...

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 28/11/2025

An international research team headed by the Bozdech lab at the Nanyang Technological University and the Gilberger lab (BNITM @uni-hamburg.de) at CSSB reveals the global landscape of protein-protein interactions that govern the biology of the malaria parasite. Find out more: t1p.de/puyln

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 27/11/2025

Researchers from @topf-lab.bsky.social, @embl.org, and IIT have visualised how a large RNA molecule assembles itself into a functional machine, revealing a dynamic choreography that helps us better understand structural folding and misfolding, almost frame by frame. More information: t1p.de/tt2hk

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 27/11/2025

📣Join us on December 9 for the Academia-Industry Matchmaking Workshop, focused on innovative solutions for challenges in the Life Sciences. Registration: indico.desy.de/event/50931/ @landaulabcssb.bsky.social @leibnizliv.bsky.social @uni-hamburg.de @fzborstel.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 26/11/2025

Using a combination of X-ray crystallography and cryo-EM, a new study from @landaulabcssb.bsky.social shows that amyloids,form different structures that could be useful as a natural mechanism of immune protection. More info: t1p.de/4n8se @amyloid-sam.bsky.social @emilgustavsson.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 24/11/2025

The Barisch lab held a 2 week practical module called 'Molecular Master Thieves' including an excursion to FZB. It was amazing & inspiring to see the students' enthusiasm & curiosity. We wish you all the best for your bright careers! @carobarisch.bsky.social @fzborstel.bsky.social @uni-hamburg.de

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 21/11/2025

On Wednesday afternoon, students who are part of DESY's ELB-Akademie programme visited CSSB. The students learned about our molecular infection research and visited the @landaulabcssb.bsky.social and our ALFM and cryo-EM facilities. Find out more about the ELB-Akademie: t1p.de/w89j6

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 20/11/2025

Congratulations to the Hamburg iGEM team for winning a gold medal in Paris for their project DeathCapTrap. @uni-hamburg.de @igemhq.bsky.social @igemcommunity.bsky.social Find out more: t1p.de/dtho1

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 10/11/2025

Congratulations to Gabriele Diana, a PhD Student in the @topf-lab.bsky.social, who received the Italian Crystallographic Association (AIC) award “Fiorenzo Mazzi” for Best Crystallographic Thesis 2025. Find out more: t1p.de/a8yuf @bosse-lab.bsky.social, @landaulabcssb.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 07/11/2025

Holger Sondermann (DESY, @uni-kiel.de) Scientific Director of CSSB, recently presented the Plenary Lecture of the Pan American Association for Biochemistry and Molecular Biology (PABMB) at SAIB 2025 in Córdoba, Argentina. @fbsisti.bsky.social Find out more: t1p.de/3alk9

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 08/10/2025

A big thank you to our Scientific Advisory Board for their engagement during out meeting this week. So many thoughtful questions and insightful comments! Hans-Georg Kräusslich, @oneyrolles.bsky.social, @sykhalid.bsky.social, @thamlab.bsky.social, Joost Enninga, Friedrich Förster, Ilaria Ferlenghi

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 08/10/2025

‪ Day 1 of our Scientific Advisory Board meeting is off to a great start. Scientific talks, lunch at @mpsdhamburg.bsky.social and a tour of #DESY 's FLASH. Looking forward to our poster session. @oneyrolles.bsky.social @sykhalid.bsky.social @thamlab.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 24/09/2025

Hamburg’s new Senator for Science, Research, and Equalities, Maryam Blumenthal, visited CSSB on Monday. She took a tour of our laboratories and core facilities, gaining insights into how CSSB scientists work together to investigate the molecular mechanisms of infection. More info: t1p.de/k9h5v

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 09/09/2025

CSSB's Uetrecht group has revealed new insights into the mechanisms of human corona viruses. Their findings were published today in @natcomms.nature.com @uniluebeck.bsky.social @leibnizliv.bsky.social Find out more: t1p.de/7ij0e

Comparing polyprotein processing in four human coronaviruses revealed distinct and common features like delayed cutting between nsp7 and nsp8. AlphaFold3 models (here SARS-CoV-2 nsp7-11) showed that this cleavage site can form a helix. The methyltransferase nsp16 binds nsp10 depending on the virus even prior release from the polyprotein. IMAGE: Kira Schamoni-Kast

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 04/09/2025

Researchers from CSSB & @mpi-nat.bsky.social have generated a highly potent nanobody that neutralizes a protein essential for the herpes virus infection. Published in @nature.com, the findings promise new therapies to treat & prevent infections @leibnizliv.bsky.social @uni-hamburg.de t1p.de/cxt7a

3D-Animation of the nanobody (light yellow/semi-transparent) inhibiting HSV-2 glycoprotein B. The different domains of gB are color-coded. Three domains are held together by the footprint of the nanobody. IMAGE: Benjamin Vollmer / Centre for Structural Systems Biology

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 04/08/2025

Good News! Registration deadline is August 31, 2025! You can still register to join @landaulabcssb.bsky.social for their Functional Amyloid Meeting! landau-cssb.de/registration/ @meytallandau.bsky.social @emilgustavsson.bsky.social @amyloid-sam.bsky.social

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 25/07/2025

Joost Schymkowitz & Frederic Rousseau from the Switch Laboratory, @cbdresearch.bsky.social will give a talk at the Functional Amyloid Meeting Register today: landau-cssb.de/registration/ @landaulabcssb.bsky.social @meytallandau.bsky.social @emilgustavsson.bsky.social @amyloid-sam.bsky.social

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