iiinova — where your digital self keeps evolving

RAPP OptoElectronic @rappopto.bsky.social · 01/10/2026

🔬 High-res 3D imaging without labels: #holotomography uses refractive index as intrinsic contrast for quantitative imaging of living samples. Next week at @cssbhamburg.bsky.social , we’ll demo the @tomocube.bsky.social HT-X1™ Plus hands-on with participant samples. Book your spot: shorturl.at/Pu2U3

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RAPP OptoElectronic @rappopto.bsky.social · 29/09/2026

🧑‍🔬Am 3.10. sieht es bei RAPP ein bisschen anders aus als sonst. Gemeinsam folgen wir dem Licht: von den Grundlagen der Optik bis in den biologischen Mikrokosmos. 🔗Mikroskopie selbst erleben: ein Gedanke, den wir auch mit @gerbi-gmb.de teilen. #TürenAufMitDerMaus #Wissenschaftskommunikation #WissKomm

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RAPP OptoElectronic @rappopto.bsky.social · 25/09/2026

1/3 💡 What makes Sutter Instrument’s BOB™ stand out as a #Microscopy platform? It removes the conventional microscope frame and creates an open-design upright platform that can adapt to the experiment.

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RAPP OptoElectronic @rappopto.bsky.social · 22/09/2026

1/3 🤔 How do you know whether an #LCM system actually fits your workflow? A useful place to start: specimen type, capture strategy, sample preparation, sample custody, and downstream analysis. #LaserCaptureMicrodissection

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RAPP OptoElectronic @rappopto.bsky.social · 17/09/2026

1/2 ✨ In some #photomanipulation workflows, it is beneficial to illuminate larger ROIs. 👉 That is the unique feature of the UGA-42 Geo: The system reshapes the laser spot into 40 preset hardware-defined illumination geometries, including 🟢 circles, 🟨 squares, and ⭕ donuts in different sizes.

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RAPP OptoElectronic @rappopto.bsky.social · 15/09/2026

🐭 Kinder haben diese wunderbare, unerschöpfliche Neugier. Dafür öffnen wir unsere Türen & geben einen spielerischen Einblick in Licht, Optik & den biologischen Mikrokosmos. 🔬 Die Begeisterung für Mikroskopie & Wissenstransfer teilen wir auch mit @gerbi-gmb.de #Wissenschaftskommunikation #WissKomm

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RAPP OptoElectronic @rappopto.bsky.social · 10/09/2026

🔬 Different papers, different biological questions, yet one shared core principle: #microscopy can go beyond observation alone. Exciting to see advanced #photomanipulation tools used so creatively in research. 👏 Congrats to all authors. ⬇️ Links to papers below.

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RAPP OptoElectronic @rappopto.bsky.social · 07/09/2026

1/3 ✨ What is holographic #photostimulation? It uses spatial light modulation (SLM) to shape a laser beam into defined light patterns, enabling tunable 3D illumination and simultaneous targeting of multiple selected ROIs within the field of view.

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RAPP OptoElectronic @rappopto.bsky.social · 04/09/2026

✨ Manchmal sind es die kleinsten Dinge, die die größten Fragen auslösen. Am 3.10. laden wir Kinder ein, Optik und Mikroskopie selbst zu entdecken. 🔗 Ein Thema, das uns auch mit @gerbi-gmb.de verbindet: Mikroskopie verständlich und zugänglich machen. #WissKomm #Wissenschaftskommunikation

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RAPP OptoElectronic @rappopto.bsky.social · 04/09/2026

Very happy to see our colleague Simona Stelea presenting at @ceitec.eu’s @ceitec-cellimcf.bsky.social at @masarykuniversity.bsky.social in Brno on the September, 22! 😊 ✨ A great chance to explore how #photomanipulation turns light into an active tool in microscopy. Thanks for hosting! 🙏

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RAPP OptoElectronic @rappopto.bsky.social · 02/09/2026

1/4 #LaserCaptureMicrodissection enables the isolation of selected cells or tissue regions for downstream analysis. But selection is only part of the workflow. The key question: can you verify that the selected material was actually captured?

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RAPP OptoElectronic @rappopto.bsky.social · 27/08/2026

1/3 🔬 X 🟣 = ⁉️ Can your #microscope handle Deep-UV? Standard microscope optics and objectives are usually not designed to transmit light below approx. 330 nm. That means that even if a Deep-UV source is available, the microscope itself may limit what actually reaches the sample.

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RAPP OptoElectronic @rappopto.bsky.social · 25/08/2026

1/5 🤔 How can we study biomolecular condensate phase behavior directly inside living cells? In a Chemistry – A European Journal paper by @chemistryeurope.bsky.social, Mosbach et al. investigate PFKL glucosomes: dynamic condensates linked to glucose metabolism.

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RAPP OptoElectronic @rappopto.bsky.social · 19/08/2026

1/3 🔬 In #microscopy, the mantra has long been: seeing is believing. Much of modern #bioimaging has pushed resolution, sensitivity and speed. ⚡ But microscopy can go beyond observation.

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RAPP OptoElectronic @rappopto.bsky.social · 12/08/2026

1/3 👉 The Accuva Cellect by @Laxco, Inc. is purpose-built for #LaserCaptureMicrodissection workflows where precision, preparation flexibility, and sample verification matter. 📖 Learn more about the Accuva Cellect #LCM system and possible workflows on the RAPP website.

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RAPP OptoElectronic @rappopto.bsky.social · 04/08/2026

1/3 👉 Not every #photomanipulation experiment needs rapid beam positioning or simultaneous illumination of multiple areas. For many workflows, local light delivery in the center of the FOV is exactly what is needed.

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RAPP OptoElectronic @rappopto.bsky.social · 30/07/2026

1/3 💡 What if #photostimulation could match the 3D structure of your sample? Holo4D uses SLM-based holographic beam shaping to project defined light patterns onto selected cells or clusters, bridging #multiphoton imaging with targeted 3D stimulation.

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RAPP OptoElectronic @rappopto.bsky.social · 28/07/2026

1/2 🌡️ What if temperature control became your next #photomanipulation tool? Temperature plays a central role in biology. It can influence protein activity, molecular interactions, reaction rates, and cellular behavior. 🔍 Many questions need more precision than whole-sample heating can provide.

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RAPP OptoElectronic @rappopto.bsky.social · 23/07/2026

1/3 🤔 Did you know an existing Olympus BX51WI can be upgraded into a 2P microscope? ➡️ With @Sutter’s DF-Scope®, a familiar lab workhorse for electrophysiology, transmitted-light and epifluorescence workflows gains the key optics/electronics for #TwoPhotonMicroscopy.

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RAPP OptoElectronic @rappopto.bsky.social · 21/07/2026

1/3 🪄 Modern #microscopy is no longer only about observing samples. 🌀 With #FLUCS, a rapidly scanned IR laser creates controlled, localized thermoviscous flows inside the sample, turning the microscope into a tool for active, non-invasive flow perturbation.

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RAPP OptoElectronic @rappopto.bsky.social · 17/07/2026

1/3 🔬 Today is the final day of our in-person #LaserCaptureMicrodissection demo at @mpibiochem.bsky.social. Thank you to the Matthias Mann group and Martin Spitaler for the hospitality and support throughout the week.

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RAPP OptoElectronic @rappopto.bsky.social · 15/07/2026

1/3 🔬 Yesterday at @mpibiochem.bsky.social: two #AccuvaCellect talks and demo sessions. In the morning, we presented to the Matthias Mann group and connected #LCM to #DeepVisualProteomics: AI-based phenotype analysis, laser microdissection and ultrasensitive #MassSpectrometry.

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RAPP OptoElectronic @rappopto.bsky.social · 09/07/2026

1/2 🔬 Live demo next week: #AccuvaCellect at the @mpibiochem.bsky.social in Martinsried. We invite researchers to experience #LaserCaptureMicrodissection hands-on and discuss sample isolation workflows. 👏 A huge thank you to Martin Spitaler for his invaluable support in organizing the demo.

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RAPP OptoElectronic @rappopto.bsky.social · 07/07/2026

1/3 🧠⚡ First day at #FENS2026, and the atmosphere is already electric. The venue is buzzing with positive energy, and we’re excited to be in Barcelona with the #neuroscience community.

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RAPP OptoElectronic @rappopto.bsky.social · 03/07/2026

1/4 🧠 #FENS2026 is around the corner, and we’re excited to join the #neuroscience community in Barcelona. Ahead of the meeting, we’re highlighting one of our favorite platforms to customize: the Sutter Instrument Moveable Objective Microscope, or MOM.

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RAPP OptoElectronic @rappopto.bsky.social · 01/07/2026

1/2 🧠 Next stop: #FENS2026 in Barcelona. 📅 From July 6–10, we’ll join the #neuroscience community together with our long-standing partners Chroma Technology Corp. and TOPTICA Photonics. 😊 Come by and talk to @swarnck.bsky.social and @martinbrill.bsky.social.

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RAPP OptoElectronic @rappopto.bsky.social · 25/06/2026

1/2 ☀️ Conference season is in full swing. So, let's talk about what RAPP does. ➡️ Short answer: modular, customizable optical solutions for #microscopy, configured around your experimental setup and application. Here’s a quick-start guide to the RAPP portfolio before heading off to #FENS2026.

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RAPP OptoElectronic @rappopto.bsky.social · 23/06/2026

1/3 ✨ #ELMI2026 wrapped on Friday, and what a week in Coimbra. Old friends, new connections, great talks, and the open #ELMI atmosphere we love. 🙏 Huge thanks to our hosts & organizers from the @ppbioimaging.bsky.social and to the @eulimi.bsky.social community for a beautifully run meeting.

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RAPP OptoElectronic @rappopto.bsky.social · 18/06/2026

1/3 ✨ Closing day of #ELMI2026 in Coimbra. Time flies when it’s this much fun: microscopy, great conversations, old friends, new connections, coffee breaks, and the open ELMI atmosphere we love. 📸 As a small thank you, here are some of our favorite impressions over the past few days.

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RAPP OptoElectronic @rappopto.bsky.social · 16/06/2026

1/2 ✨ Day 1 at #ELMI2026 is in full swing, and booth no. 10 is already *the* place to be. 🤝 We’re sharing the booth with our good friends Almut Bailly and Zain Ali from Chroma Technology Corp. and Helge Schmidt from TOPTICA Photonics.

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RAPP OptoElectronic @rappopto.bsky.social · 11/06/2026

🔬 The #EMBO | #EMBL Symposium "Mechanobiology across the tree of life" is well underway here in Heidelberg. 💡 Come by our booth to talk about #photomanipulation, laser ablation, #FLUCS, and custom microscopy solutions for #mechanobiology experiments. 👋 See you at the booth! #EESMechanobiology

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RAPP OptoElectronic @rappopto.bsky.social · 09/06/2026

☀️ June is here, and conference season is in full swing. We are excited to be joining the #EESMechanobiology in #EMBLHeidelberg and connecting with the #mechanobiology community. 👏 Thank you to the scientific organizers, @embo.org, @embl.org, and @events.embl.org for bringing this symposium together.

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RAPP OptoElectronic @rappopto.bsky.social · 03/06/2026

1/2 ✨ We are truly delighted to be a Gold Sponsor of #ELMI2026. 🤝 We are also especially pleased to share a booth with our good friends from Chroma Technology Corp. and TOPTICA Photonics as we rely on strong collaborations and trusted, long-term partnerships.

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RAPP OptoElectronic @rappopto.bsky.social · 01/06/2026

🎉 Congratulations to all authors on this brilliant paper and the well-deserved JCB cover feature! 👏 A beautiful study connecting cortical cytoskeleton organization, cell shape, signaling, and epidermal differentiation. We are truly excited to see our technology contribute to this outstanding work.

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RAPP OptoElectronic @rappopto.bsky.social · 01/06/2026

1/3 How does the cortical #cytoskeleton connect cell shape w/ cell fate? A recent @jcb.org @rupress.org paper by Soffer et al. uses the #epidermis to study how shape transitions are coordinated w/ differentiation. The study identifies #spectrin as an essential organizer of the #actomyosin cortex.

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RAPP OptoElectronic @rappopto.bsky.social · 28/05/2026

1/2 🧬 For #DNArepair studies, chemically-induced damage is often too blunt. 🎯 Local laser-induced #DNAdamage changes the experimental game. Instead of damaging the whole sample, one can target a selected nuclear region and follow the response over time with #LiveImaging. #Microscopy #Bioimaging

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RAPP OptoElectronic @rappopto.bsky.social · 26/05/2026

1/4 🔬 In many tissue samples, the region of interest is surrounded by material you do *not* want in your downstream analysis. #LCM helps isolate selected cells or tissue regions with higher specificity before DNA, RNA, or protein analysis. #Microscopy #Bioimaging #LaserCaptureMicrodissection

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RAPP OptoElectronic @rappopto.bsky.social · 22/05/2026

1/4 🌱 Biologists spend enormous effort keeping their favorite organisms happy. But to understand biology, one often needs to perturb it. 🎯 Precisely. 💡 That is where #photomanipulation comes in: focused light used to locally modify, stimulate, cut, or disrupt processes in a sample.

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RAPP OptoElectronic @rappopto.bsky.social · 19/05/2026

1/3 😬Every live-cell microscopist knows the feeling: the fluorescence signal looked perfect when the experiment started. 🔬In #FluorescenceMicroscopy, prolonged/intense excitation can permanently destroy fluorophores. ❌For #LiveCellImaging, that means fine details becoming harder to resolve.

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RAPP OptoElectronic @rappopto.bsky.social · 13/05/2026

1/2 🇩🇪 We are pleased to support the EMBL @events.embl.org Course “Advanced Fluorescence Imaging Techniques” in Heidelberg together with #Evident Microscopy. ✨ Anja Zimmermann will contribute to the course with a talk and hands-on workshops on RAPP #photomanipulation systems. #EMBLFluorImaging

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RAPP OptoElectronic @rappopto.bsky.social · 11/05/2026

1/3 🪄 What if you could move intracellular structures using only light? 🌀 FLUCS uses a rapidly scanned IR laser to generate thermoviscous flows inside the sample. ❌ No contact ❌ No labels ❌ No RI matching required ✅ Just your sample & IR light #Photomanipulation #Microscopy #Bioimaging #Biophysics

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Reposted by RAPP OptoElectronic

RAPP OptoElectronic @rappopto.bsky.social · 08/05/2026

1/3 💡 What makes the @sutterinstrument.bsky.social MOM® stand out? It is built around a simple idea: move the objective, not the specimen. Its open, robust design makes it a flexible platform built to serve evolving workflows for years to come. #Microscopy #Bioimaging

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RAPP OptoElectronic @rappopto.bsky.social · 08/05/2026

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RAPP OptoElectronic @rappopto.bsky.social · 05/05/2026

1/3 🫀 Atherosclerotic lesions are #plaque buildups in the arterial wall that reduce blood flow. Foam cells, i.e., lipid-laden macrophages, are central to plaque progression. 💔 As lesions advance, the outcome can be severe: thrombosis, heart attack, or stroke. #LaserCaptureMicrodissection

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RAPP OptoElectronic @rappopto.bsky.social · 30/04/2026

1/2 ✨Mark and track only the molecules you choose. 🔦 #Photoactivation: Signal appears only after local illumination. 🎨 #Photoconversion: Contextual tracking, where you can mark a selected population but observe both the converted and unconverted populations. ➡️The real power of both? Spatial control.

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RAPP OptoElectronic @rappopto.bsky.social · 28/04/2026

1/3 UGA-42 is a scanner-based #photomanipulation series for microscopy and macroscopy. It places the laser virtually anywhere in the camera/scanner's field of view for sequential point illumination and ROI scanning. #Microscopy #Bioimaging

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RAPP OptoElectronic @rappopto.bsky.social · 23/04/2026

1/3 ❓What makes holographic #photomanipulation different from point stimulation? ✨With Holo4D, light is shaped differently. An SLM creates defined holographic patterns that can be projected simultaneously in 3D. 📌x⏱️That turns sequential targeting into spatially coordinated stimulation across time.

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RAPP OptoElectronic @rappopto.bsky.social · 21/04/2026

1/2 🤔 Single- or multi-photon #microscopy? 🔘 A #confocal pinhole rejects out-of-focus fluorescence at detection, but excitation still happens along the beam path. ✨ In #multiphoton, fluorescence is generated mainly at the focal volume, supporting deeper, gentler imaging in sensitive live specimens.

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RAPP OptoElectronic @rappopto.bsky.social · 17/04/2026

📈or📉? Your downstream data is only as good as your starting material. Accuva Cellect offers IR capture & UV laser cutting in one #LCM system and a dedicated QC station for visual inspection. 👉 Or to put it simply: Cut. Capture. Verify. #LaserCaptureMicrodissection

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RAPP OptoElectronic @rappopto.bsky.social · 14/04/2026

1/2 🌈x🛠️ Light can become a versatile tool in your experiments. Photomanipulation is the controlled use of focused light to locally modify/stimulate/disrupt biological & physical processes in a sample. ❓Which photomanipulation approach could unlock the most interesting possibilities for your biology?

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