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Jesus Angulo

@angulo-lab.bsky.social
519 followers 203 following 25 posts

PhD in Chemistry. NMR, Computational Chemistry, Structural Glycobiology, Ligand-based drug design. "What I cannot create, I do not understand (R. Feynman)" angulolab.iiq.us-csic.es

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Jesus Angulo @angulo-lab.bsky.social · 20/04/2026
Last Saturday we had a tasting of the real life "ss-NMR" protocol: "Sherry-Saturday: No More Research". 🍷🍷 Jerez de la Frontera (Spain)
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Jesus Angulo @angulo-lab.bsky.social · 19/11/2025
The III Workshop of the MSCA-DN GlyCanDrug started in Seville at cicCartuja @csic.es on 18.11.2025. Four days of glycoscience and cancer, as well as top soft skill courses for the 10 PhD students of the network.
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 31/10/2025
Science brings us new miracles every day. Update from a mother whose son was the first patient dosed with Grace Science's gene therapy for NGly1 deficiency (GS-100). Video can be seen on YouTube. #glycotime www.youtube.com/watch?v=tdNn...
youtube.com
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Jesus Angulo @angulo-lab.bsky.social · 24/10/2025
Really excited about this work! We hope Fast NMR scoring can contribute to drug discovery. Thanks Dusan Uhrin @edinburghchem.bsky.social and Ridvan Nepravishta @rnepravishta.bsky.social @crhorizons.bsky.social for getting us on board of this collaboration. @csic.es pubs.acs.org/doi/10.1021/...
pubs.acs.org
Fast and Reliable NMR-Based Fragment Scoring for Drug Discovery
Fragment-Based Drug Discovery (FBDD) is a powerful strategy used in the development of new therapeutics. Molecular fragments are screened against a target protein, where interactions are typically cha...
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Jesus Angulo @angulo-lab.bsky.social · 06/09/2025
Big congrats to Jona for his successful defence of his PhD Thesis. Thanks to the panel @albasilipo.bsky.social Paco Corzana, Pedro Nieto, Victoria Gómez and Miguel A. Rodríguez Carvajal. Great NMR cake for the celebration!!! @csic.es
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Jesus Angulo @angulo-lab.bsky.social · 02/09/2025
A heads-up: Friday 5th 11am, first PhD defence in the @angulo-lab.bsky.social since the lab move to Seville. It'll be at cicCartuja @csic.es. Jona's presenting his work on some pretty cool new STD NMR approaches for low-affinity biomolecular interactions. Co-supervised with Juan C. Muñoz-García.
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CIC bioGUNE @cicbiogune.bsky.social · 24/07/2025
#bioGUNE_Talent | 👏 Óscar Millet #CICbioGUNE @brtaeus.bsky.social, appointed Vice President of @group-ampere.bsky.social, Europe’s top #NMR organization, the first Spanish scientist to hold this role 🎉 Congratulations, Óscar! 🔗 ow.ly/hxi450Wuwiw
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Jesus Angulo @angulo-lab.bsky.social · 04/07/2025
Great week of science in Bilbao @ XL Meeting of the Spanish Royal Society of Chemistry @rseq-quimica.bsky.social. I really enjoyed presenting our developments in Epitope-Perturbation-by-Mutation STD NMR spectroscopy in my invited talk. It opened great discussions with fantastic colleagues. @csic.es
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Jesus Angulo @angulo-lab.bsky.social · 01/06/2025
On our way to Jaca #NMRschool #ManuelRicoNMR #NMR2025
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Jesus Angulo @angulo-lab.bsky.social · 05/05/2025
Starting our mid-term meeting @GlyCanDrug at @i3S_UPorto in Porto. Putting together the glycoscience we're developing in our European Doctoral Network
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Glyco@Alps @glyco-alps.bsky.social · 12/03/2025
Registration to our "Structural Glycoscience" Summer School is open !! Come to Grenoble for #glycotime lectures, practicals, visit to @esrf.fr @cermav.bsky.social and IBS. Information and registration at glycoalps.univ-grenoble-alpes.fr/news/summer-...
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Anne Imberty @anneimb.bsky.social · 12/03/2025
Our famous "Structural Glycoscience" summer school is back in June 2025 in Grenoble !! with @angulo-lab.bsky.social @elisafadda.bsky.social @glycoexpasy.bsky.social @romain-vives.bsky.social and many others. Attendance is limited to 40 so register quickly !
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Jesus Angulo @angulo-lab.bsky.social · 05/03/2025
Our first paper on STD NMR Epitope Perturbation by Mutation: Unveiling Mechanism of YM155 as an Arginine-Glycosyltransferases Inhibitor Effective in Treating Enteropathogenic Diseases pubs.acs.org/doi/10.1021/... Great collabor. Ramón Hurtado, Weston Struwe, Valeria Calvaresi, and Philip Hardwidge
pubs.acs.org
STD NMR Epitope Perturbation by Mutation Unveils the Mechanism of YM155 as an Arginine-Glycosyltransferases Inhibitor Effective in Treating Enteropathogenic Diseases
Enteropathogenic arginine-glycosyltransferases (Arg-GTs) alter higher eukaryotic proteins by attaching a GlcNAc residue to arginine acceptor sites, disrupting essential pathways such as NF-κB signalin...
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Jesus Angulo @angulo-lab.bsky.social · 22/01/2025
A privilege to have my former boss Thomas Peters visit our research group in Seville @csic.es, as an invited speaker at the III @GlycoNoVi Workshop.
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Jesus Angulo @angulo-lab.bsky.social · 20/01/2025
Excellent scientific discussions today!! III workshop of the "GlycoNoVi" MSCA-DN European Network in Seville. We thank cicCartuja @csic.es for kindly hosting our meeting at the research centre. (#MSCA-DN)
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Lara K. Mahal @glycocode.bsky.social · 13/01/2025
Proud of @faezehjame.bsky.social and our latest paper on upregulation by #miRNA. miRNA upregulate protein expression of CD98hc, ST3GAL1 and ST3GAL2 in a coordinated manner. Regulation is bidirectional, changing the picture on how these #RNA work. #glycotime www.science.org/doi/10.1126/... 🧪
science.org
Screening the human miRNA interactome reveals coordinated up-regulation in melanoma, adding bidirectional regulation to miRNA networks
Analysis of ST3GAL1/2 and CD98hc regulation by miRNA reveals co–up-regulation, adding a bidirectional twist to miRNA networks.
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Jesus Angulo @angulo-lab.bsky.social · 10/01/2025
Today, we officially welcome Pablo Valverde to the group, working on our @csic.es MOMENTUM project. Starting gun fired for exciting computational+NMR times to characterise challenging weak protein-ligand interactions.
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Derek Lowe @dereklowe.bsky.social · 03/01/2025
RIP J. Fraser Stoddart and Martin Karplus.
science.org
Two More Great Names Pass
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Jesus Angulo @angulo-lab.bsky.social · 12/12/2024
Attention recent PhD's (thesis finished in 2023 or 2024): the ‘Juan de la Cierva’ call is opening. 2 year postdoc contract! Interested in molecular recognition for development of new drugs (NMR spectroscopy, computation, AI, biophysical techniques)? Contact us! www.aei.gob.es/convocatoria...
aei.gob.es
Ayudas para contratos Juan de la Cierva 2024 | Agencia Estatal de InvestigaciónBuscar
Las ayudas Juan de la Cierva tienen como finalidad fomentar la incorporación de jóvenes, en posesión del grado de doctor, con objeto de que completen su formación investigadora postdoctoral en centros de I+D españoles.
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Jesus Angulo @angulo-lab.bsky.social · 05/12/2024
Xmas is coming to the lab...
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Elisa Fadda @elisafadda.bsky.social · 04/12/2024
Fancy glycan of the week 🍬: here ⬇️ is THE fanciest tetrantennary+SDa antigen bisected N-glycan I have ever seen! Found in bovine pregnancy-associated glycoproteins (PAGs) during midpregnancy, see doi.org/10.1093/glyc... This (and its core-fucosylated companion) will be soon on glycoshape.org 😀👍
one of the 3D structures of a tetrantennary, bisected N-glycan represented with sticks and a transparent surface to indicate its molecular volume. SNFG symbols are used to represent each monosacharide
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Martina Delbianco @delbiancom.bsky.social · 04/12/2024
#PhDposition available in my group at the @mpici.bsky.social! Join us to develop new #carbohydratematerials #chemistryjobs #researchjobs #glycotime jobs.mpikg.mpg.de/jobposting/a...
jobs.mpikg.mpg.de
PhD position to develop synthetic carbohydrate materials
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Alexander Titz @titzlab.bsky.social · 04/12/2024
I am very proud to share a long story on lectins and biofilm imaging just published in JACS Au by Eva and Lisa in cooperation with many colleagues such as @anneimb.bsky.social 😍 #glycotime #chembio #AMR please have a look here: pubs.acs.org/doi/10.1021/...
pubs.acs.org
High-Affinity Lectin Ligands Enable the Detection of Pathogenic Pseudomonas aeruginosa Biofilms: Implications for Diagnostics and Therapy
Pseudomonas aeruginosa is a critical priority pathogen and causes life-threatening acute and biofilm-associated chronic infections. The choice of suitable treatment for complicated infections requires...
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Anne Imberty @anneimb.bsky.social · 04/12/2024
This was an amazing collaboration with high affinity ligand for Pseudomonas aeruginosa lectins able to target the bacteria in mice !! #glycotime 🍾
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Gaston Courtade @gcourtade.bsky.social · 04/12/2024
Perspective by Higman et al: deposition of data for titrations, relaxation rates, PREs, etc in a standardized way, e.g. the NEF format could help develop AI models to accurately predict the dynamic behaviour of a protein from the primary sequence alone. #NMRchat doi.org/10.1007/s108...
doi.org
Perspective: on the importance of extensive, high-quality and reliable deposition of biomolecular NMR data in the age of artificial intelligence - Journal of Biomolecular NMR
Artificial intelligence (AI) models are revolutionising scientific data analysis but are reliant on large training data sets. While artificial training data can be used in the context of NMR processin...
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Ralph Adams @ralphwadams.bsky.social · 01/12/2024
🎄 Exciting News for NMR Enthusiasts! 🎄 This December, join us for an NMR Advent Calendar! 🧪📅 New challenge unlocked on our website each day. 🔓 Starts Today - 1st of December 💻 Visit: nmr.chemistry.manchester.ac.uk/advent24 🎁 Test your knowledge, learn, and have fun! #NMRchat #AdventCalendar
nmr.chemistry.manchester.ac.uk
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Jesus Angulo @angulo-lab.bsky.social · 01/12/2024
Sunday coffee time dilation... What a beautiful view!! 😍
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Magnetic Resonance News @nmr900.bsky.social · 28/11/2024
Postdoctoral Position at the University of Gothenburg (Sweden) – Developing AI tools for Biomolecular NMR and Structural Biology, posted 11/26/2024 listes.services.cnrs.fr/wws/arc/nmr/... #NMRjobs #NMRchat #NMR 🧲
listes.services.cnrs.fr
nmr - Magnetic Resonance Mailing List - confirm_action
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M. Eugenio Vazquez @glowsticks.bsky.social · 28/11/2024
If you have the right profile 💻, you should seriously consider this offer as a once-in-a-lifetime opportunity. Manuel is not only an exceptional scientist, but also—and this is crucial for potential students and postdocs—a kind person who cares about his people.
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 27/11/2024
X has copied the starter pack concept 😂
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Fabien Ferrage @fabferrage.bsky.social · 11/11/2024
I am happy to share the preprint of a review coordinated by my colleague Giacomo Parigi on relaxometry of biomolecules systems. doi.org/10.26434/che...
doi.org
Field-dependent relaxation profiles of biomolecular systems
The function of biomolecular systems, including biological macromolecules, often crucially depends on their dynamics. Nuclear Magnetic Resonance (NMR) is one of the most informative methods used to st...
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Anne Imberty @anneimb.bsky.social · 19/11/2024
Awesome webinar by @elisafadda.bsky.social at GlyGen. series. Everything you should know for building the GLYCO of your glycoproteins with GlycoShape (glycoshape.org)
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Jesus Angulo @angulo-lab.bsky.social · 22/11/2024
Proud of Henry Flatau, PhD student of our group after being awarded the Prize for Best Oral Presentation at the PhD Students Congress at the Chemistry Faculty of the University of Seville. NMR spectroscopy, computational chemistry & (bio)molecular interactions.
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Jesus Angulo @angulo-lab.bsky.social · 21/11/2024
It was a great privilege to chair the ChemBio VII conference (www.chembiovii.es) held in Seville. The organizing committee worked very hard to make the meeting a success. Amazing contributions and discussions in Chemical Biology with colleagues, with the beautiful Seville as a backdrop.
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Max Planck Institute of Colloids & Interfaces (MPICI) @mpici.bsky.social · 21/11/2024
Congrats to @delbiancom.bsky.social for winning the "European Award for Young Research Leaders of the Spanish Specialized Group of #ChemicalBiology"! Read how she designs synthetic #glycans to explore their untapped potential for #MaterialsScience ➡️https://tinyurl.com/4nxd5s6b #skychem
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Prof. Zoë Waller @drzoewaller.bsky.social · 20/11/2024
Grateful for the opportunity to be able to present and discuss our work at ChemBio VII in Seville. Thank you to Jesus Angulo for the kind invitation- and also for taking this photo!
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Elisa Fadda @elisafadda.bsky.social · 18/11/2024
If you are interested or working in #structuralbiology, as you see any protein (yes, *any*), you should be thinking: is it glycosylated? The answer is likely to be yes! You can predict N-glycosylation sites and rebuild all types of glycans with ReGlyco glycoshape.org 😌 Check out the example ⬇️ 1/2
Left, cry-EM structure of the complex between MIK2 (green), the immunoregulatory peptide SCOOP (yellow) and the LRR of the co-receptor BAK1 (white) with only the most rigid part of the N-glycans resolved (1 or 2 or none) and represented with sticks. Right, reconstruction of the N-glycosylation with plant N-glycans G90477LS,selected to be all the same as glycoproteomics data is not available (as far as I know)
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Jesus Angulo @angulo-lab.bsky.social · 17/11/2024
White and red "matured grape juice" to celebrate meeting, after many years, former members of the lab Serena Monaco and Ridvan Nepravishta in Seville. Happy to see them doing, and looking, so well! www.chembiovii.es/CHEMBIOVII2024
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Jesus Angulo @angulo-lab.bsky.social · 15/11/2024
The Angulo lab working hard to have everything ready and in place for the ChemBio VII Meeting this Monday in Seville (www.chembiovii.es/CHEMBIOVII2024 )
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Jon Agirre @glycojones.bsky.social · 14/11/2024
Here is a great opportunity to join YSBL (York) and work with @mjplevin.bsky.social and myself! www.findaphd.com/phds/project...
findaphd.com
Application of Deep Learning (AI) to the refinement of XH-π interactions in protein atomic structure determination at University of York on FindAPhD.com
PhD Project - Application of Deep Learning (AI) to the refinement of XH-π interactions in protein atomic structure determination at University of York, listed on FindAPhD.com
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Marcin Czerwinski @czerwinsmarcin.bsky.social · 13/11/2024
Interesting piece about glycosylated RNAs (glycoRNAs): sialylated glycoRNAs are present in human cell lines, and sialylation of glycoRNAs depends on the catalytic isoforms of the oligosaccharyltransferase (OST) complex. tinyurl.com/vhz2rj8a
tinyurl.com
Processing of N-glycans in the ER and Golgi influences the production of surface sialylated glycoRNA - Glycoconjugate Journal
Glycoconjugates, including glycans on proteins and lipids, have obtained significant attention due to their critical roles in both intracellular and intercellular biological functions and processes. N...
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Elisa Fadda @elisafadda.bsky.social · 13/11/2024
Here below is a slide summarising all that you can do with glycoshape today! And so much more to come soon! Any questions/feedback please let us know! 2/2
'One slide' flyer listing all the tools and resources available on glycoshape to date
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Elisa Fadda @elisafadda.bsky.social · 13/11/2024
As we (my lab and I) are new here 😻, let me introduce some exciting #glycotime work we recently published in Nature Methods doi.org/10.1038/s415... GlycoShape is a completely OA database and toolbox to restore the 3D structure of glycans on glycoproteins 🥳 You can find it at glycoshape.org 1/2
artistic rendition of glycoproteins 3D structures anchored on the cell surface and soluble with the glycans restored with https://glycoshape.org
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Max Planck Institute of Colloids & Interfaces (MPICI) @mpici.bsky.social · 12/11/2024
The Society for #Glycobiology has awarded its Distinguished Service #Award to the editors of "Essentials of Glycobiology", including our Director, Peter Seeberger. ➡️ academic.oup.com/glycob/artic... (end of page) #glycotime
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Jesus Angulo @angulo-lab.bsky.social · 12/11/2024
Hello everyone!! New in this BlueSky... I share with you our study on the IT-sialidase from R. gnavus RgNanH-GH33. Brilliant collaboration with Nathalie Juge (Quadram Institute, Norwich), and all the work led by Serena Monaco (UEA, Norwich). www.sciencedirect.com/science/arti...
sciencedirect.com
Multifrequency-STD NMR unveils the first Michaelis complex of an intramolecular trans-sialidase from Ruminococcus gnavus
RgNanH is an intramolecular trans-sialidase expressed by the human gut symbiont Ruminococcus gnavus, to utilise intestinal sialylated mucin glycan epi…
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