The immune landscape of healthy prostate and its alterations during prostate cancer (PCa) progression remain poorly characterized. Using scRNA-sequencing and multiparametric flow-cytometry analysis...

Previous research has suggested that pDCs are required for an effective antiviral immune response, but direct experimental evidence to support this is lacking. Here Ngo et al. develop a pDC knockin mouse model and find that pDCs are dispensable for an antiviral immune response to mouse cytomegalovirus and may be detrimental during influenza or SARS-CoV-2 infection.

À Marseille, la scientifique Réjane Rua rêve de faire avancer la recherche contre Alzheimer

We demonstrate that exposure to the AB5 subtilase cytotoxin (SubAB) induces the unfolded protein response (UPR) in human peripheral blood mononucle...

The immune and sensory nervous systems work in concert to defend against threats and maintain homeostasis. In this issue of Immunity, Ugolini and colleagues review how immune signals activate speciali...

Dysregulated CD4 T cells have been implicated in autoimmune liver disease, but their phenotypes and origin are still unclear. Here the authors profile circulating, autoreactive CD4 T cells to find tra...

In this study, authors identify the omentum, a tertiary lymphoid organ part of the fat tissue, as a reservoir for Brucella abortus, which promotes bacterial persistence and causes CD4+ and CD8+ T cell...

RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.