Nature Reviews Molecular Cell Biology, Published online: 29 July 2026; doi:10.1038/s41580-026-01007-6Gene escape from X-chromosome inactivation can cause sex-biased diseases. A workflow is presented to help find escape genes and experimentally manipulate their expression.

Gene escape from X-chromosome inactivation can cause sex-biased diseases. A workflow is presented to help find escape genes and experimentally manipulate their expression.

Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...

Current human gene annotations are predominantly based on individuals of European ancestry. Here, the authors use long-read RNA sequencing across diverse human populations to reveal ancestry-specific ...

Ahmed et al. define tRNA-overlapping lncRNAs (tROLs). tROLs in gene-dense regions interact between chromosomes and depend on each other’s transcription. tROL perturbations silence codon-biased genes i...

Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...

In aging female mice, genes on the second X chromosome become active again. This could be an explanation for sex differences in aging humans regarding disease.

A study reports on the DNA methylation dynamics during embryogenesis in marsupials, showing that these differ from those occurring during embryogenesis in eutherian mammals.

Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human gene annotations are largely derived from transcriptomic...

Eukaryotic cells are highly structured and composed of multiple membrane-bound and membraneless organelles. Subcellular RNA localization is a critical regulator of RNA function, influencing various bi...