Nature - Chronic reactivation of distinct herpesviruses and anelloviruses occur during acute and long COVID-19, and track with disease severity, inflammation and outcomes, revealing immune...

A scalable library of ∼13,000 barcoded viral open reading frames from >500 viral species enables functional genomic screens across the virome. Applying this platform identified viral regulators of cellular proliferation, antigen presentation, and interferon signaling. This platform enables systematic exploration of viral protein function.

All kingdoms of life have developed strategies to limit viral infection. In humans, interferons induce a suite of antiviral factors that collectively provide immunity. Some human immune genes are homo...

Dai et al. present a large-scale analysis of off-target binding in clinical-stage therapeutic antibodies. Their findings reveal an unexpectedly high prevalence of specific off-target interactions and ...

Immune systems in animals, plants, and bacteria often rely on intracellular nucleotide signaling, which viruses can block by sequestering or degrading these signals. We identified structural and bioph...

Latest AlphaFold Database update adds high-value datasets for microbial and viral proteins, generated by specialist communities

Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...

Nature - Correlates of HIV-1 control after combination immunotherapy

Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to …

Nature - Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome

Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for use as therapeutic agents. Here we introduce Phold, an annotation framework utilis...

MSK researchers are helping to map the landscape of viruses that infect us all, and to analyze the impact they have on human health and disease.

Programmable Enrichment via RNA FlowFISH by sequencing (PERFF-seq) isolates rare cells based on RNA marker transcripts for single-cell RNA sequencing profiling of complex tissues, with applicability t...