TIRTL-seq is a high-throughput method for paired T cell receptor sequencing at the cohort scale.

An in vivo model that is able to recover human T cells from solid tumours can identify targets to help improve CAR T cell antitumour activity.

Fractalkine-conjugated mRNA-LNPs effectively target cytotoxic effector CD8 T cells for transient in vivo reprogramming.

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Over the last few years a number of studies aiming to cure HIV or at least achieve long-term viral suppression off antiretroviral therapy (ART) have produced tantalising results. These studies have given participants one or both of the long-acting versions of two broadly neutralising antibodies (bnAbs), 3BNC117 (teropavimab) and 10-1074 (zinlirvimab), sometimes in conjunction with immune boosting oral drugs.

Large-scale study finds that simplifying delivery of prevention medication and improving connections to clinics is key

Schober and colleagues show that effector CD8+ T cells undergo metabolic shutdown, CD8+ central memory T cells are the most metabolically active, and naive-like memory T cells are quiescent during the...

A comprehensive atlas platform integrating transcriptional and epigenetic data enables more precise engineering of T cell states, accelerating the rational design of more effective cellular immunother...

Rajesh T Gandhi, Ronald J Bosch, Ann Chahroudi; New Insights from Perinatal HIV: A Way Forward for HIV Cure Research, The Journal of Infectious Diseases, ,

Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...

A quiet policy change means the government is making fewer bets on long-term science.

Seven of 10 volunteers kept HIV at bay for months after stopping meds, a rare result scientists call a major step toward a functional cure.

Nature - Correlates of HIV-1 control after combination immunotherapy

The National AIDS Memorial, through a partnership with the AIDS Quilt Touch team, presents all 48,000 panels of the AIDS Memorial Quilt in an interactive experience People around the world can experie...

Urge your members of Congress to fully fund federal HIV programs as they negotiate final funding levels for the FY 2026 LHHS spending bill.

LIFE.com shares the story behind one of the most harrowing and controversial photographs to emerge from the global pandemic.

Research into T cells holds the potential to make advances in HIV therapies and the treatment of conditions such as cancer and autoimmune diseases.