Advances in technology continue to refine our understanding of CD8 T cell memory, with major implications for next-generation vaccines and therapies.

A chemokine–nucleic acid nanoparticle adjuvant elicits protective mucosal immunity against genital herpes simplex virus 2 infection in mice.

Fractalkine-conjugated mRNA-LNPs effectively target cytotoxic effector CD8 T cells for transient in vivo reprogramming.

This Review discusses both fetal and maternal immune responses that influence the development of congenital Zika syndrome.

LLMs assessed with “The Creation Game” show promise in aiding systems vaccinology discovery while remaining human dependent.

Maternal IgG transfer and neonatal infection synergize via Fc receptor pathways to promote allergic TH2 immunity.

Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies.

Inhibitory immune checkpoints for cancer immunotherapy are reviewed.

Programmable gene integration in human cells has the potential to enable mutation-agnostic treatments for loss-of-function genetic diseases and facilitate many applications in the life sciences. CRISP...

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Expanded CD4+ T cell clones preferentially adopt a single fate in malaria, and TR1 cells dominate and display long-term memory.

The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.

ZBP1 and mitochondrial Z-DNA drive autoimmune photosensitivity via cGAS-STING activation.

Repression of STING expression in neutrophils and T lymphocytes is required for immune homeostasis and tumor response.

Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...

AAV delivery of antibodies targeting the SIV envelope glycoprotein contains virus replication in macaques after stopping ART.

TRAF3 integrates early cell-intrinsic and cell-extrinsic signals to initiate TFH cell differentiation.

Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

Single-cell and spatial multiomics analyses identify breakout lesions as a hotspot for tumor-immune interactions and diversification.

TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants.

DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer.

Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...

Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.

A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity.

The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.