This Review discusses both fetal and maternal immune responses that influence the development of congenital Zika syndrome.

Waning immunity to Japanese encephalitis virus was associated with increased severity of dengue disease in a cohort of patients from Nepal.

Waning immunity to Japanese encephalitis virus was associated with increased severity of dengue disease in a cohort of patients from Nepal.

Fetal microglia are protective against Zika virus, but primitive macrophages and monocytes promote neuroinflammation and are disease promoting. Different fetal immune and neuronal cell types are targeted by different Zika lineages.