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Tom Scriba

@tomscriba.bsky.social
963 followers 73 following 73 posts

Professor in Immunology at University of Cape Town, Deputy Director at South African Tuberculosis Vaccine Initiative. Views are my own.

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Reposted by Tom Scriba
Peter MacPherson @petermacp.bsky.social · 19/09/2026
Very pleased to contribute to this meta-analysis. Among contacts of #TB, protection from preventive therapy waned quickly in high incidence settings, but persisted for years in low and medium incidence settings authors.elsevier.com/sd/article/S... @uofgshw.bsky.social 🦠🧪🛟
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Eric Topol @erictopol.bsky.social · 11/09/2026
Most supplements and vitamins have little or no proven benefit, and even some have potential of harm, but that hasn't held back ~80% Americans taking them, highest proportion ever www.nytimes.com/2026/09/11/w...
nytimes.com
Supplements Are More Popular Than Ever (Gift Article)
A new survey found that 8 in 10 Americans were taking vitamins, protein powders or other supplements. But experts said many offer little to no benefit.
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TAGHIVscience @taghivscience.bsky.social · 31/08/2026
Now published in @natcomms.nature.com www.nature.com/articles/s41... (open access) #tuberculosis #TB
nature.com
Inflammatory biomarkers of asymptomatic and symptomatic tuberculosis - Nature Communications
A large number of individuals with tuberculosis (TB) are asymptomatic. Here, the authors characterise blood transcriptomic and proteomic profiles in South African community screening cohorts to identi...
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Spotlight @spotlightnsp.bsky.social · 28/08/2026
TB VACCINE | A pivotal clinical trial could pave the way for a new TB vaccine in more than a century. As we await the results, Russell Rensburg argues that it’s time to start preparing for the broader realities of rolling out the jab. www.spotlightnsp.co.za/2026/08/28/s...
spotlightnsp.co.za
SA is one step closer to a new TB vaccine, but there is a lot of work ahead
In March 2024, a pivotal clinical trial was launched to evaluate what might well become the first new tuberculosis vaccine on the market in more than a century. As anticipation mounts for the trial to...
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Madhu Pai, MD, PhD @madhupai.bsky.social · 26/08/2026
😔 Newborn deaths are surging in the world’s most vulnerable communities as aid cuts hit www.independent.co.uk/news/health/...
independent.co.uk
Newborn deaths are surging in the world’s most vulnerable communities. Here’s why
Mothers across sub-Saharan Africa face a perfect storm of conflict, displacement and global aid cuts that are leaving them without the help they need in the most dangerous countries to give birth. Liz...
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Tom Scriba @tomscriba.bsky.social · 20/08/2026
Really very good news for South African investigators! Though many will remain weary about risks posed by short-term reversals of such decisions, as frequently seen in the last 18 months. NIH lifts ban on funding research in South Africa | Science | AAAS www.science.org/content/arti...
science.org
NIH lifts ban on funding research in South Africa
Researchers who study HIV, tuberculosis, and other infectious disease in the country welcome policy change
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Reposted by Tom Scriba
Nature @nature.com · 19/08/2026
Lab meetings don’t always have to be so formulaic go.nature.com/4qnykGh
go.nature.com
Twenty-two easy ways to power up your lab meetings
Scientists share help and advice on how they got their research discussions flowing.
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Louis Ates @mycolates.bsky.social · 19/08/2026
Amazing TB vaccine PostDoc opportunities with one of the best in the field. Don't think Rasmus is on here. So thought I'd share like this #TBsky
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Science Magazine @science.org · 17/08/2026
"Those who believe in free, open, and responsive institutions must recognize how critically linked science is to democracy itself and defend its integrity with every tool at their disposal," writes John Palfrey in a new #ScienceEditorial. scim.ag/4i9awDH
Quote from John Palfrey of the John D. and Catherine T. MacArthur Foundation: "Funding science means supporting the truth that lies at the heart of every democracy ..."
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Tom Scriba @tomscriba.bsky.social · 11/08/2026
Just unbelievable what damage this will do! www.bbc.com/news/article...
bbc.com
Trump signs order to limit childhood vaccines and split MMR shots
The American Academy of Pediatrics calls the recommendation on measles, mumps and rubella shots "dangerous".
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Eric Topol @erictopol.bsky.social · 11/08/2026
Vaccine benefit in children "Since 1974, vaccination has averted 154 million deaths, including 146 million among children younger than 5 years of whom 101 million were infants younger than 1 year." www.thelancet.com/journals/lan... The most striking benefit was for vaccination vs measles (Figure)
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Tom Scriba @tomscriba.bsky.social · 31/07/2026
Write-up on our latest story about the inflammatory response in asymptomatic TB. Will share the paper link in thread. www.news.uct.ac.za/article/-202...
news.uct.ac.za
Asymptomatic TB: A hidden challenge for TB control
UCT researchers have published new findings that challenge current approaches to TB detection and control in South Africa.
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Tom Scriba @tomscriba.bsky.social · 29/07/2026
www.news.uct.ac.za/article/-202...
news.uct.ac.za
Winelands learners win top research prize in Ireland
Two teenagers who are members of the Youth Research Advisory Group linked to the South African Tuberculosis Vaccine Initiative at UCT have won a global accolade.
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Nature @nature.com · 24/07/2026
Peptide injections are the hottest trend in wellness. Researchers say enthusiasm for these unregulated drugs has got ahead of the science go.nature.com/4wUKtV2
go.nature.com
Is the peptide craze backed by science? The promise behind the hype
Peptide injections are the hottest trend in wellness. Researchers say enthusiasm for these unregulated drugs has got ahead of the science.
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Tom Scriba @tomscriba.bsky.social · 25/07/2026
Mid-winter run on the southern slopes of Table Mountain - what a pleasure
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Tom Scriba @tomscriba.bsky.social · 03/07/2026
Excellent review on the safety and efficacy of mRNA vaccines: a mechanistic and public health perspective - The Lancet www.thelancet.com/journals/lan...
thelancet.com
Safety and efficacy of mRNA vaccines: a mechanistic and public health perspective
mRNA vaccines represent a transformative advance in vaccinology, combining rapid development timelines, scalable manufacturing, and strong immunogenicity with a favourable safety profile. Global deplo...
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Reposted by Tom Scriba
Jeff Spencer @revjss.bsky.social · 02/07/2026
Graphic offering advice on “How to survive the global heatwave.” It says:
Stay hydrated.
Treat yourself to an ice cream.
Dismantle the fossil fuel industry which is literally burning the planet for the short term profit of a vanishingly small capitalist class.
Loose fitting clothing.
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James Seddon @jaseddon.bsky.social · 01/07/2026
We are looking for an amazing person to join our team as a Project Manager to support me across a portfolio of child and adolescent TB studies. Use the following link su.ac.za/en/careers-su to apply.
su.ac.za
Careers at SU
Careers at SU
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Spotlight @spotlightnsp.bsky.social · 01/07/2026
IN THE SPOTLIGHT | Globally, childhood vaccines have saved an estimated 154 million lives since 1974. In this special briefing, we detail which vaccines are in used in South Africa. www.spotlightnsp.co.za/2026/07/01/i...
spotlightnsp.co.za
In The Spotlight | What is in SA’s vaccination schedule and how does it measure up?
Which vaccines are in use in South Africa and how does our vaccination schedule measure up to international standards? In this #InTheSpotlight special briefing, Catherine Tomlinson unpacks the recent ...
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Spotlight @spotlightnsp.bsky.social · 25/06/2026
SHINGLES VACCINE | A new, more effective shingles vaccine is finally set to hit the market in South Africa. The vaccine, Shingrix, should soon be available at private sector pharmacies, but availability in the public sector seems unlikely for the time being. www.spotlightnsp.co.za/2026/06/25/n...
spotlightnsp.co.za
New shingles vaccine to be launched in SA private sector, but affordability may limit access
Ten years after its launch in the United States, a new, more effective shingles vaccine is finally set to hit the market in South Africa. While the vaccine, called Shingrix, should soon be available a...
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James Seddon @jaseddon.bsky.social · 19/06/2026
Exciting opportunity for a Medical Officer and a Study Nurse to join our research team at the Desmond Tutu TB Centre to work on the newly funded DEFIANT study to evaluate the impact of puberty on host immune responses to Mtb. www.linkedin.com/jobs/view/44... www.linkedin.com/jobs/view/44...
linkedin.com
Stellenbosch University hiring Medical Officer in Stellenbosch, Western Cape, South Africa | LinkedIn
Posted 12:42:57 PM. Department Description/Departement BeskrywingFaculty of Medicine and Health SciencesDesmond Tutu TB…See this and similar jobs on LinkedIn.
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Tom Scriba @tomscriba.bsky.social · 11/06/2026
Cape Town Marathon lands Major status in first for Africa
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Eric Topol @erictopol.bsky.social · 10/06/2026
Chronic air pollution exposure (even moderate) and more advanced coronary artery disease pubs.rsna.org/doi/10.1148/...
pubs.rsna.org
Sex-Specific Associations between Long-term Air Pollution Exposure and Coronary Atherosclerosis at Cardiac CT | Radiology
Long-term exposure to air pollution, even at moderate levels, is independently associated with greater coronary artery calcium extent and total plaque burden at cardiac CT.
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Katharine Hayhoe @katharinehayhoe.com · 26/05/2026
Perhaps the fact that we are conducting an unprecedented experiment with the only home we have, by digging up and burning massive amounts of fossil fuels that is driving global change at rates 10X faster than the most recent warming of this magnitude that occurred oh about 55 million years ago? 🧐
bbc.com
Why temperature records are being not only broken but smashed
The combined effects of a heat dome and climate change have brought extreme warmth to western Europe.
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Katharine Hayhoe @katharinehayhoe.com · 26/05/2026
This BBC article states that "climate change is believed to have played a role in such hot spells as this." Let me fix it: Climate change IS making these hot spells more likely and more dangerous. Scientists have been warning of this for decades. www.bbc.com/news/article...
bbc.com
Hottest May day on record in UK as temperatures pass 34C
It comes after the UK recorded its warmest May night on Sunday when temperatures reached 19.4C.
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Tom Scriba @tomscriba.bsky.social · 21/05/2026
www.sciencedirect.com/science/arti...
sciencedirect.com
Beyond subawards: funding Global South institutions to lead biomedical research
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Reposted by Tom Scriba
Madhu Pai, MD, PhD @madhupai.bsky.social · 18/05/2026
Tuberculosis kills on a vast scale, but as foreign aid shrinks, countries with a high burden of TB stand to gain a lot by investing more to curb the disease and its heavy social cost @economist.com impact.economist.com/health-socie...
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Spotlight @spotlightnsp.bsky.social · 07/05/2026
SCIENCE AND STRATEGY STAR | Professor Willem Hanekom tells Spotlight about taking a ventilated young patient to the Sea Point promenade, living with HIV, the need for an African research agenda, and the recurring joy that has defined his career. www.spotlightnsp.co.za/2026/05/07/t...
spotlightnsp.co.za
To the US and back: SA’s Prof Willem Hanekom reflects on the joys of science and a career ‘running with opportunities’
At his Durban office, Professor Willem Hanekom tells Biénne Huisman about taking a ventilated young patient to the Sea Point promenade, living with HIV, the need for an African research agenda, and th...
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Nature Portfolio @natureportfolio.nature.com · 04/05/2026
A Review in Communications Medicine explores Long COVID — which affects more than 400 million people globally — including current knowledge, gaps and future directions for research, diagnosis and treatment. go.nature.com/4unyxtI #medsky 🧪
This is figure 1, which shows a summary of the pathophysiology of Long COVID.
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Science Magazine @science.org · 04/05/2026
Bangladesh is in the grip of an explosive measles epidemic, stemming from a catastrophic breakdown in vaccine procurement following the country’s 2024 revolution. The result was nationwide vaccine shortages and plummeting immunization rates. scim.ag/4tM2lAr
scim.ag
Measles explodes in Bangladesh after vaccination breakdown, killing hundreds of children
Changes to government’s vaccine purchase system after 2024 revolution led to nationwide shortages, gaps in immunity
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Daniel L. Barber, PhD @danbarberphd.bsky.social · 29/04/2026
So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. rdcu.be/ff9GB #tuberculosis #immunology
rdcu.be
IFNγ blockade in Mycobacterium tuberculosis infected macaques alters the granuloma environment but not bacterial control
Nature Communications - Here, the authors show that IFNγ blockade does not impair resistance to Mycobacterium tuberculosis infection in macaques, opposed to what has been observed in mice, due...
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BK. Titanji @boghuma.bsky.social · 01/05/2026
Beautifully done and important trial. An effective mTb test that utilizes tongue swab specimens will be absolutely transformative for Tb diagnosis especially is resource limited settings. Definitely practice modifying. www.nejm.org/doi/full/10....
nejm.org
Pulmonary Tuberculosis Detection with MiniDock MTB Using Swab Samples | NEJM
Improved diagnostic tools for tuberculosis that are suitable for use in peripheral health centers are essential for reducing the persistent gap between estimated and notified cases. The diagnostic ...
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PLOS Medicine @plosmedicine.org · 08/04/2026
In this mathematical modelling study, Katherine Horton & co assess #TB community screening approaches & their estimated effects on TB incidence & mortality, concluding that methods that capture both infectious & non-infectious TB are needed to achieve sustained case reductions🧪 plos.io/4tuD2SM
plos.io
Trade-offs in diagnostic algorithm, population coverage, and duration of community screening for tuberculosis: A modelling study
In a mathematical modelling study, Katherine Horton and colleagues assess different tuberculosis (TB) community screening approaches and their estimated effects on TB incidence and mortality over ten ...
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Katherine Horton @kchorton.bsky.social · 09/04/2026
In our latest paper in @plosmedicine.org, we explore trade-offs in diagnostic algorithm, coverage, and duration of community screening for #TB, highlighting the importance of symptom-agnostic approaches and the need for strategies to sustain impact when screening ends. plos.io/4tuD2SM
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Marcus Low @marcuslowx.bsky.social · 23/03/2026
A fascinating long read for World TB Day #tbsky @stoptb.bsky.social @madhupai.bsky.social @treatmentactiongroup.org @tomscriba.bsky.social
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Spotlight @spotlightnsp.bsky.social · 16/03/2026
DATA MUST DRIVE ACTION | South Africa's new TB dashboard is a win for transparency. The data must now help boost TB testing and find the people still missing from care, say leading TB activists. www.spotlightnsp.co.za/2026/03/16/a...
spotlightnsp.co.za
A new TB dashboard can help boost testing, we need to make the most of it
The new government TB dashboard is a step forward for transparency and accountability in South Africa’s response to the ancient, but still deadly, disease. It is critical that we use it wisely to boos...
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Spotlight @spotlightnsp.bsky.social · 17/03/2026
NEW HOPE | For more than a century, the world has relied on a single TB vaccine. That could finally change with top South African researchers playing a key role. Associate Professor Angelique Kany Kany Luabeya explains why this moment matters. www.spotlightnsp.co.za/2026/03/17/t...
spotlightnsp.co.za
The hunt for a new TB vaccine: Why we are now so close, and why it matters
The only tuberculosis vaccine we have is a century old and offers only limited efficacy in children. With leading South African researchers involved in the pivotal clinical trials of three new tubercu...
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Adam Kucharski @adamjkucharski.bsky.social · 14/03/2026
"When intending to upload code, some researchers have also accidentally published partial or entire Biobank datasets to GitHub, a popular online code-sharing platform." www.theguardian.com/science/2026...
theguardian.com
Confidential health records from UK BioBank project exposed online
Exclusive: Guardian investigation finds data from flagship medical research leaked dozens of times
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Tom Scriba @tomscriba.bsky.social · 11/03/2026
41 Celsius in Cape Town today
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South African Tuberculosis Vaccine Initiative (SATVI) @satviuct.bsky.social · 05/03/2026
We have a vacancy for Data Scientist position within our dynamic clinical immunology group. To apply visit the UCT online job portal at: www.uct.ac.za
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Tom Scriba @tomscriba.bsky.social · 03/03/2026
Pretty depressing stuff www.nature.com/articles/d41...
nature.com
Hey ChatGPT, write me a fictional paper: these LLMs are willing to commit academic fraud
Mainstream chatbots presented varying levels of resistance to deliberate requests for fabrication, study finds.
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South African Tuberculosis Vaccine Initiative (SATVI) @satviuct.bsky.social · 01/03/2026
Latest research: Estimating the population impact of new tuberculosis vaccines depending on efficacy against infectious asymptomatic tuberculosis: A modelling study appearing in the @plosmedicine.org journal. pubmed.ncbi.nlm.nih.gov/41678562/
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Bhekisisa Centre for Health Journalism @bhekisisa.org · 26/02/2026
#ClimateChange isn’t just melting ice caps. It’s changing pollen seasons, worsening air pollution and increasing breathing problems in South Africa. Learn how to report it accurately — and compellingly. Sign up for our webinar. forms.gle/NTHCHkMnZiG7...
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PLOS Medicine @plosmedicine.org · 24/02/2026
In this modeling study, Allison Portnoy and colleagues investigate the potential impact of reduced international donor funding on the household economic burden of tuberculosis in low- and middle-income countries 🧪 #MedSky #TB plos.io/4ryyBFX
plos.io
The potential impact of reduced international donor funding on the household economic burden of tuberculosis in low- and middle-income countries: A modeling study
In a modelling study, Allison Portnoy and colleagues investigate the potential impact of reduced international donor funding on the household economic burden of Tuberculosis in low- and middle-income ...
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Rebecca Clark @raclark18.bsky.social · 24/02/2026
Our recent modelling study found that the estimated impact of new TB vaccines depends on the efficacy to prevent infectious asymptomatic TB. Read more in our paper out now in @plosmedicine.org! journals.plos.org/plosmedicine...
journals.plos.org
Estimating the population impact of new tuberculosis vaccines depending on efficacy against infectious asymptomatic tuberculosis: A modelling study
Hira Tanvir and colleagues estimate the potential impact of new tuberculosis vaccines under three scenarios of efficacy and conclude that to achieve the greatest impact, vaccines must prevent asymptom...
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Science Magazine @science.org · 10/02/2026
A new paper levels fresh allegations of questionable scientific practices by the Bandim Health Project, an embattled group led by researchers in Denmark that has long studied vaccines in West Africa and has recently become influential in U.S. health policy. scim.ag/3ZY7NCR
science.org
Controversial Danish vaccine research group faces new allegations
Researchers say they couldn’t find complete data for 10 trials that together enrolled tens of thousands of children in Guinea-Bissau
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Nature @nature.com · 10/02/2026
Almost all of the scientists were previously at US institutions go.nature.com/4qMlrUR
go.nature.com
Dozens of researchers will move to France from US following high-profile bid to lure talent
Large proportion worked at Columbia University, which had its grants cut and frozen by the administration of US President Donald Trump.
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Eric Topol @erictopol.bsky.social · 06/02/2026
The real story about statin safety from >122,000 RCT participants with individual level data. They can cause new-onset diabetes and muscle pain/weakness, but other than that they are remarkably safe for 62 outcomes. Rare liver function test abnormalities thelancet.com/journals/lan...
thelancet.com
Assessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials
Adverse event data from blinded randomised trials do not support causal relationships between statin therapy and most of the conditions (including cognitive impairment, depression, sleep disturbance, ...
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Tom Scriba @tomscriba.bsky.social · 05/02/2026
Very interesting paper: M. tuberculosis proteins under diversifying selection and the T cell responses that target them. Could these be good TB vaccine antigens? JCI Insight: Rare variable M. tuberculosis antigens induce predominant Th17 responses in human infection insight.jci.org/articles/vie...
insight.jci.org
JCI Insight - Rare variable M. tuberculosis antigens induce predominant Th17 responses in human infection
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Nature @nature.com · 02/02/2026
Book review 📚 Are health influencers making us sick? go.nature.com/4tsEOoq
go.nature.com
Are health influencers making us sick?
Social media can help to raise awareness of health conditions — but the wealth of dubious information online might do more harm than good.
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