Human induced GC-like B (iGCB) cells are generated in vitro from circulating naive or marginal zone cells.

A mechanistic basis for how the hormone salicylic acid promotes transcriptional activation during plant immune responses is described.

B cell receptor isotype–intrinsic characteristics regulate plasma cell generation and migratory programs.

In aging hosts, platelet serotonin fuels lung-damaging clots, leading to enhanced respiratory distress in the context of COVID-19.

Divergent B cell memory strategies evolved in lung and gut mucosa to counteract recurrent pathogens.

Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.

The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.

Asparagine metabolism is a critical regulator of germinal center B cell function.

Asparagine metabolism is a critical regulator of germinal center B cell function.

Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.

KEAP1 promotes persistent T cell immunity and a stem-like T cell response during chronic antigen stimulation by repressing NRF2.

Loss-of-function mutations in LTBR result in a stromal defect, leading to dysfunctional secondary lymphoid organs and combined immunodeficiency in humans.

Targeting TIM-3 palmitoylation mediated by DHHC9 enhances CAR-T cell– and NK cell–based tumor immunotherapy by suppressing immune exhaustion.