Coordinated development requires that growth and cell-fate transitions occur in a defined temporal order across tissues, yet how multicellular orga...

In mammals, cohesin and CTCF organize the 3D genome into topologically associating domains (TADs) to regulate communication between <i>cis</i>-regulatory elements. Many organisms, including <i>S. cere...

The Trump administration hobbles research and endangers the public health.

Grants from the National Institutes of Health come with additional money for overhead. A planned $4 billion cut would leave colleges with large budget gaps.

WASHINGTON—Putting the nation on alert against what it has described as a “highly credible terrorist threat,” the FBI announced today that it has uncovered a plot by members of al-Qaeda to sit back an...

Here, the authors study the effects of expression quantitative trait loci on enhancer activity and promoter contacts in primary monocytes isolated from male individuals, suggesting an inherent genetic...

TV personality embeds in one of several raids in US cities in what Tom Homan says are only ‘beginning stages’

The majority of initiating RNA polymerase II (RNAPII) terminates early, generating an abundance of short RNAs that require sorting into productive or destructive pathways. Here, Garland and Jensen explore early quality-control mechanisms that govern the fate of short RNAs, preventing the accumulation of non-functional transcripts and ensuring proper RNA processing.

microRNAs (miRNAs) and small interfering RNAs (siRNAs) are 21- to 22-nucleotide RNAs that guide Argonaute-class effectors to targets for repression. In this work, we uncover 5-aminolevulinic acid synt...

Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.

YouTube video by Nobel Prize

Kamel et al. apply complementary approaches to elucidate the composition of Sindbis virus ribonucleoproteins. They identified a subset of nuclear proteins that selectively translocate to the cytoplasm, interact with viral RNA, and suppress virus infection. Among them, U2 snRNP emerges as a ribonucleoprotein complex with moonlighting antiviral activity.

Abstract. Messenger RNA (mRNA) translation is a tightly controlled process frequently deregulated in cancer. Key to this deregulation are transfer RNAs (tR

Endogenous mitochondrial NAD(P)H fluorescence enables label-free and subcellular resolution quantification of aging, prediction of remaining lifespan and tracking of age-dependent changes to mitochond...

RNA localization and regulation are critical for cellular function, yet many live RNA imaging tools suffer from limited sensitivity due to background emissions from unbound probes. Here, we introduce ...