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Matthias Fellner

@mfellnerlab.bsky.social
36 followers 41 following 9 posts

Understand protein structure-function relationships and use this knowledge to answer fundamental questions of chemistry/biochemistry at the University of Otago.

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Matthias Fellner @mfellnerlab.bsky.social · 13/04/2026
Check out our latest publication “Carbamoyl fluorides as serine hydrolase inhibitors: a case study on FphI from Staphylococcus aureus.” doi.org/10.1016/j.bi... Great new collaboration between Otago and University of Ljubljana driven by George Randall and Anže Meden, assisted by many co-authors.
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Matthias Fellner @mfellnerlab.bsky.social · 25/03/2026
Couple of thousand protein crystals grown and hundreds of datasets later this fun project is published “Unique structural and ligand binding properties of the Staphylococcus aureus serine hydrolase FphE" www.pnas.org/doi/10.1073/... Great collaboration with @jeyunjo.bsky.social @mbogyo.bsky.social
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Reposted by Matthias Fellner
Matt Bogyo @mbogyo.bsky.social · 25/03/2026
Our latest work on the somewhat enigmatic serine hydrolase FphE from S. aureus is out. This work provides interesting structural and ligand binding insights that help to explain its biological functions. With @mfellnerlab.bsky.social - University of Otago. www.pnas.org/doi/10.1073/pnas.2532683123
pnas.org
Unique structural and ligand-binding properties of the Staphylococcus aureus serine hydrolase FphE | PNAS
Staphylococcus aureus is a human pathogen capable of forming biofilms that complicate treatment and facilitate chronic infections. A family of S. a...
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Matthias Fellner @mfellnerlab.bsky.social · 23/02/2026
One week left to apply for the protein crystallography focused 2.5 year postdoc position in my group @otagobiochemist.bsky.social : otago.taleo.net/careersectio...
otago.taleo.net
Postdoctoral Fellow - Biochemistry
Click the link provided to see the complete job description.
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Matthias Fellner @mfellnerlab.bsky.social · 02/02/2026
Join the University of Otago, New Zealand, for a 2.5‑year postdoctoral role focused on the structural and functional analysis of serine hydrolases. This project centres on solving and interpreting atomic structures to guide the development of novel antibiotics. otago.taleo.net/careersectio...
otago.taleo.net
Postdoctoral Fellow - Biochemistry
Click the link provided to see the complete job description.
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Matthias Fellner @mfellnerlab.bsky.social · 07/09/2025
Check out our latest review on digestion-resistant proteins, a collaboration with the Zhang lab (China Agricultural University) and Otago @otagobiochemist.bsky.social / Food Sciences. doi.org/10.1080/1040...
doi.org
Dual mechanisms of digestion-resistant proteins in food systems: structural resistance and enzyme inhibition
Digestion-resistant proteins, which are proteins that reduce or inhibit the digestive process of dietary nutrients, might be an emerging field to explore. Growing public interest in food compositio...
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Reposted by Matthias Fellner
Matt Bogyo @mbogyo.bsky.social · 30/05/2025
Our work identifying new covalent inhibitors of Staphylococcus aureus serine hydrolyses from fragment libraries is out! great work from @tulsiupadhyay.bsky.social and our many collaborators, including @christianslentz.bsky.social, @mfellnerlab.bsky.social. #chembio link.springer.com/article/10.1...
link.springer.com
Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation - Nature Communications
Staphylococcus aureus is a leading cause of bacteria-associated mortality worldwide. New tools are needed to both image and treat this pathogen. We previously identified a group of S. aureus serine hy...
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Matthias Fellner @mfellnerlab.bsky.social · 13/05/2025
Great collaboration with Suzanne Warring, Hazel Sisson @peterfineran.bsky.social and others to combat kiwifruit canker via an endolysin-lipase chimera, grateful to be involved, check it out here: www.jbc.org/article/S002...
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Matthias Fellner @mfellnerlab.bsky.social · 01/03/2025
Well done @sijiewang.bsky.social and everyone else involved pubs.acs.org/doi/10.1021/...
pubs.acs.org
An mRNA Display Approach for Covalent Targeting of a Staphylococcus aureus Virulence Factor
Staphylococcus aureus (S. aureus) is an opportunistic human pathogen that causes over one million deaths around the world each year. We recently identified a family of serine hydrolases termed fluorop...
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Reposted by Matthias Fellner
Matt Bogyo @mbogyo.bsky.social · 25/02/2025
Amazing work by @sijiewang.bsky.social and our collaborators is out in JACS today. Interested in covalent inhibitors of protein-protein interactions? Check it out. pubs.acs.org/doi/10.1021/...
pubs.acs.org
Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein–Protein Interactions Using Phage Display
Peptide macrocycles are promising therapeutics for a variety of disease indications due to their overall metabolic stability and potential to make highly selective binding interactions with targets. R...
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Reposted by Matthias Fellner
Christian Lentz @christianslentz.bsky.social · 11/02/2025
New article out in ACS Infectious Diseases! Using activity-based probes by H. Overkleeft, former PhD candidate @jalal228.bsky.social identified an alpha-amylase family protein of S. aureus supporting virulence during Galleria infection! @monaj66.bsky.social pubs.acs.org/doi/10.1021/...
pubs.acs.org
Activity-Based Protein Profiling Identifies an α-Amylase Family Protein Contributing to the Virulence of Methicillin-Resistant Staphylococcus aureus
In search of new putative antimicrobial drug targets in methicillin-resistant Staphylococcus aureus, we aimed to identify and characterize retaining glycosidase activities in this bacterial pathogen. ...
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Matthias Fellner @mfellnerlab.bsky.social · 29/12/2024
Happy to share our paper "Similar but Distinct—Biochemical Characterization of the Staphylococcus aureus Serine Hydrolases FphH and FphI" in PROTEINS doi.org/10.1002/prot... - cryo vs room temperature protein crystallography, SAXS, molecular dynamics and much more to uncover key enzyme differences.
FphH and FphI cryo and room temperature crystal structures.
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Matthias Fellner @mfellnerlab.bsky.social · 13/12/2024
Just out Comparative lipidomics profiles of planktonic and biofilms of methicillin-resistant and -susceptible Staphylococcus aureus: doi.org/10.1016/j.ab... MS & NMR to dig into lipid differences between strains, living states & media. Get in contact to investigate your lipids of interest together!
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