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Jalal Uddin

@jalal228.bsky.social
37 followers 63 following 5 posts

Postdoc at Yale University 🇺🇸 Ph.D., UiT 🇳🇴 Visiting Ph.D., UMC Utrecht 🇳🇱 M.Sc., Kangwon National University 🇰🇷 B.Sc., Microbiology, JU 🇧🇩 ❤️ Interested in studying gastrointestinal infections using chemical tools

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Reposted by Jalal Uddin
Matt Bogyo @mbogyo.bsky.social · 30/04/2026
Our paper showing that we can use fluorescent covalent probes to image S. aureus infections in vivo is out. Great collaboration with Tulio Valdez and super talented postdocs Emily Woods, @jeyunjo.bsky.social, and @tulsiupadhyay.bsky.social and others. onlinelibrary.wiley.com/doi/epdf/10....
onlinelibrary.wiley.com
Imaging of Staphylococcus aureus Infections and Biofilms Using a Selective Covalent Probe for the Unique Serine Hydrolase FphE
Staphylococcus aureus can form biofilms during infection, posing significant diagnostic and treatment challenges. In this paper, we characterize an oxadiazolone-based fluorescent probe, JJ-OX-012, th...
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Reposted by Jalal Uddin
Christian Lentz @christianslentz.bsky.social · 13/04/2026
Come join us! 4 year PhD position in infection biology/microbiology available associated to our newly funded Clinical Academic Group “Patient-tailored management of bacterial infections in the age of antimicrobial resistance”. Applications via: www.jobbnorge.no/en/available.... @cansuit.bsky.social
jobbnorge.no
PhD fellow in infection biology/microbiology (297648) | UiT The Arctic University of Norway
Job title: PhD fellow in infection biology/microbiology (297648), Employer: UiT The Arctic University of Norway, Deadline: Tuesday, April 28, 2026
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Reposted by Jalal Uddin
Matt Bogyo @mbogyo.bsky.social · 25/03/2026
Our latest work on the somewhat enigmatic serine hydrolase FphE from S. aureus is out. This work provides interesting structural and ligand binding insights that help to explain its biological functions. With @mfellnerlab.bsky.social - University of Otago. www.pnas.org/doi/10.1073/pnas.2532683123
pnas.org
Unique structural and ligand-binding properties of the Staphylococcus aureus serine hydrolase FphE | PNAS
Staphylococcus aureus is a human pathogen capable of forming biofilms that complicate treatment and facilitate chronic infections. A family of S. a...
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Reposted by Jalal Uddin
Matt Bogyo @mbogyo.bsky.social · 25/02/2026
Our latest work on fluorescent probes for imaging infections in vivo is out. Check it out! www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by Jalal Uddin
Stephan Hacker @stephanhacker2.bsky.social · 30/10/2025
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid? Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7) www.nature.com/articles/s41...
nature.com
Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry
Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...
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Reposted by Jalal Uddin
Matt Bogyo @mbogyo.bsky.social · 26/09/2025
After a long journey and much hard work from many talented scientists, our paper is finally out. Take a look if you are interested in proteases and host microbe interactions in the gut. www.cell.com/cell-host-mi...
cell.com
A Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation
Lakemeyer and colleagues analyze the secretome of gut bacteria to identify factors that target host PAR2. They find that the Bacteroides fragilis protease Bfp1 cleaves and activates PAR2, disrupting i...
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Reposted by Jalal Uddin
Kimberly Beatty @beattylab.bsky.social · 16/09/2025
Last chance for early registration for the 2025 Chemical Biology & Physiology Symposium (Dec. 11-13 in Portland, Oregon, USA). Register here: www.ohsu.edu/school-of-me... Great program, including talks by Carasco, Chang, Bogyo, Baskin, Swarts, Sampson, Sletten, Dodani, Francis, Urano, Gibbs, etc.
ohsu.edu
Chemical Biology and Physiology 2025 | OHSU
Chemical Biology and Physiology Conference 2025, December 11-13, 2025
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Reposted by Jalal Uddin
Matt Bogyo @mbogyo.bsky.social · 29/08/2025
Great collaboration with @derda_lab @RatmirDerda just posted to bioRxiv. Check out how to best incorporate electrophiles into cyclic peptides to generate covalent inhibitors. www.biorxiv.org/content/10.1...
biorxiv.org
A Two-Step Synthesis of Covalent Genetically-Encoded Libraries of Peptide-Derived Macrocycles (cGELs) enables use of electrophiles with diverse reactivity
Genetically-encoded libraries of peptide-derived macrocycles containing electrophile "warheads" (cGELs) can be used to identify potent and selective covalent ligands for protein targets. Such cGELs ar...
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Jalal Uddin @jalal228.bsky.social · 16/08/2025
rdcu.be/eA0FK
rdcu.be
Large-scale CRISPR screening in primary human 3D gastric organoids enables comprehensive dissection of gene-drug interactions
Nature Communications - CRISPR-Cas9-based screens have allowed the study of gene-drug interactions. Here, the authors develop CRISPR-Cas9 knock-out, activation and repression screens in human...
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Reposted by Jalal Uddin
Hatzios Lab @hatzioslab.bsky.social · 04/08/2025
Congrats to postdoc Zhe Zhou on her paper out today in @cp-cellhostmicrobe.bsky.social showing that gut bacteria cross-feed a common dietary antioxidant to produce energy under anaerobic conditions. Thanks to collaborators Angela Jiang and Xiaofang Jiang at NIH. www.sciencedirect.com/science/arti...
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Reposted by Jalal Uddin
Stephan Hacker @stephanhacker2.bsky.social · 24/07/2025
An inspiring paper by the group of Jacob Geri in Analytical Chemistry. They present a method for residue-specific #chemoproteomics without the need for an enrichment step. To achieve this, they developed reagents that shift the ion mobility for gas phase separation. pubs.acs.org/doi/full/10....
pubs.acs.org
Gas Phase Separation of Modified Peptides for Activity-Based Protein Profiling
Profiling the reactivity of the proteome with amino-acid level resolution requires the identification and quantification of reacted peptides in the presence of abundant unmodified peptides. Affinity-b...
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Reposted by Jalal Uddin
Stephan Hacker @stephanhacker2.bsky.social · 02/07/2025
A new exciting article in @natbiotech.nature.com highlights the power of chemical proteomics to find druggable pockets on difficult high-value targets. Great insights into applications in covalent and non-covalent drug discovery including clinical development. (1/5) www.nature.com/articles/s41...
nature.com
Probing the proteome - Nature Biotechnology
Chemical proteomics has brought rigor to covalent drug discovery and drugs to the clinic. Can it deliver a new generation of drug targets?
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Jalal Uddin @jalal228.bsky.social · 20/06/2025
Congratulations to Dr. Stavroula Hatzios on this well-deserved recognition! 👏
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Jalal Uddin @jalal228.bsky.social · 17/06/2025
Pleased to share our lab-optimized chapter in Methods in Molecular Biology: “Activity-Based Protein Profiling of Serine Hydrolases in Bacteria.” Thanks to @christianslentz.bsky.social . doi.org/10.1007/978-...
doi.org
Activity-Based Protein Profiling of Serine Hydrolases in Bacteria: Methods and Protocols
Activity-based protein profiling (ABPP) is a chemoproteomic technique that uses functionalized covalent enzyme inhibitors known as activity-based probes (ABPs) to detect, quantify, and identify active...
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Reposted by Jalal Uddin
Matt Bogyo @mbogyo.bsky.social · 30/05/2025
Our work identifying new covalent inhibitors of Staphylococcus aureus serine hydrolyses from fragment libraries is out! great work from @tulsiupadhyay.bsky.social and our many collaborators, including @christianslentz.bsky.social, @mfellnerlab.bsky.social. #chembio link.springer.com/article/10.1...
link.springer.com
Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation - Nature Communications
Staphylococcus aureus is a leading cause of bacteria-associated mortality worldwide. New tools are needed to both image and treat this pathogen. We previously identified a group of S. aureus serine hy...
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Reposted by Jalal Uddin
Matt Bogyo @mbogyo.bsky.social · 19/04/2025
If you are interested in lipids in bacteria, check out this awesome new review written by my talented student Alyssa Carter, super postdoc Emily Woods and me. #chembio www.sciencedirect.com/science/arti...
sciencedirect.com
Chemical strategies for targeting lipid pathways in bacterial pathogens
Microbial pathogens continue to plague human health and develop resistance to our current frontline treatments. Over the last few decades, there has b…
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Reposted by Jalal Uddin
Matt Bogyo @mbogyo.bsky.social · 16/01/2025
Excited to report our studies that identified a new serine protease secreted by the gut microbe Bacteroides fragilis that regulates pain and inflammation through PAR2 activation. #ChemBio. Check it out!https://www.biorxiv.org/content/10.1101/2025.01.15.633241v1
biorxiv.org
Identification of a secreted protease from Bacteroides fragilis that induces intestinal pain and inflammation by cleavage of PAR2
Protease-activated receptor 2 (PAR2) is a central regulator of intestinal barrier function, inflammation and pain. Upregulated intestinal proteolysis and PAR2-signaling are implicated in inflammatory ...
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Jalal Uddin @jalal228.bsky.social · 11/02/2025
Thanks a lot @monaj66.bsky.social 😊
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Jalal Uddin @jalal228.bsky.social · 11/02/2025
Our paper. Thanks a lot @christianslentz.bsky.social 😊
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