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Thomas Boettcher

@thomasboettcher.bsky.social
153 followers 158 following 24 posts

Professor of Microbial Biochemistry at University of Vienna at the Faculty of Chemistry and CeMESS. Investigating microbial metabolites and modulating bacterial behavior. #ChemicalBiology #Phages #Antibiotics boettcher-lab.univie.ac.at

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Thomas Boettcher @thomasboettcher.bsky.social · 21/07/2026
Österreich sollte nicht die gleichen Fehler wie Deutschland mit den unsäglichen #WissZeitVG Reformen machen, welche die Situation für alle Beteiligten nur massiv verschlechtert haben. Wir brauchen Flexibilität, um die besten Köpfe gewinnen und halten zu können. @univie.ac.at orf.at/stories/3434...
orf.at
Unis: Holzleitner will Teilzeitstudium
Wissenschaftsministerin Eva-Maria Holzleitner (SPÖ) plant die Einführung von Wissenschaftsregionen und die Möglichkeit, ein Studium in Teilzeit zu absolvieren. Parallelangebote am gleichen Standort so...
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Universität Wien / University of Vienna @univie.ac.at · 20/05/2026
Unis rufen zu Demos gegen Kürzungen auf‼️ Die Unis befürchten Einsparungen von einer Mrd. Euro im #Budget. Rektorensprecherin Brigitte Hütter sprach bei einer Pressekonferenz von einem "Supergau" für Unis, Wirtschaft und Gesellschaft. Rektor Schütze sprach von enormen Schaden für die Reputation. ⤵️
univie.ac.at
Budget - Unis rufen zu Demos gegen Kürzungen auf
Rektor Schütze:
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Cluster of Excellence 'MicroPlanet' @microbesplanet.bsky.social · 05/02/2026
3/3 🐝CoE Postdoc @davidszamosvari.bsky.social from @thomasboettcher.bsky.social lab @Faculty of Chemistry @univie.ac.at explores specialized enzymes breaking down complex wax esters in human skin, beeswax, and plant cuticles. More info: www.microplanet.at/index.php/re...
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Cluster of Excellence 'MicroPlanet' @microbesplanet.bsky.social · 28/01/2026
Congrats to CoE Key Researcher @thomasboettcher.bsky.social @univie.ac.at on his ERC Proof of Concept Grant! 👏 His project, PhageTRAP, uses a modular platform to capture and release phages to tackle antibiotic resistance and advance biotech. @fwf-at.bsky.social @erc.europa.eu #MicroSky #AMR #ERCPoC
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Universität Wien / University of Vienna @univie.ac.at · 27/01/2026
Der Chemiker @thomasboettcher.bsky.social erhält einen Proof of Concept Grant des @erc.europa.eu. Wir gratulieren herzlichst! 🎉 Im Projekt 'PhageTRAP' entwickelt Thomas Böttcher eine modulare Plattform, die Bakteriophagen mithilfe synthetischer Erkennungsmotive gezielt einfängt und freisetzt. ⤵️ 🧪
univie.ac.at
Neuer ERC Proof of Concept für die Universität Wien
Förderung für den Chemiker Thomas Böttcher
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Thomas Boettcher @thomasboettcher.bsky.social · 17/01/2026
Proud to see our work on bacteriophage inhibitors featured on one of the covers of the first issue of this year of @rscchembio.rsc.org
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Cluster of Excellence 'MicroPlanet' @microbesplanet.bsky.social · 16/01/2026
Congrats to CoE Key Researcher @thomasboettcher.bsky.social @univie.ac.at on securing @fwf-at.bsky.social funding for Collaborative Research Centre with @dfg.de. Focus on bacterial effector proteins, infection mechanisms, and therapeutic strategies. cemess.univie.ac.at/news-detail/...
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cemess_vienna @cemess.bsky.social · 08/01/2026
Congratulations to Thomas Böttcher and his team @univie.ac.at, Faculty of Chemistry | #CeMESS) on @fwf-at.bsky.social “International – Multilateral Initiatives” funding alongside @dfg.de for “CRC 1756”! Learn more 🔗 cemess.univie.ac.at/news-detail/...
cemess.univie.ac.at
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Thomas Boettcher @thomasboettcher.bsky.social · 23/12/2025
Just hot from the press: nice work by Konstantin Plöchl of our lab on solute binding proteins of P. aeruginosa out now in Scientific Reports. www.nature.com/articles/s41...
nature.com
The solute-binding proteins DppA1–5 of Pseudomonas aeruginosa have distinct substrate profiles - Scientific Reports
Scientific Reports - The solute-binding proteins DppA1–5 of Pseudomonas aeruginosa have distinct substrate profiles
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Thomas Boettcher @thomasboettcher.bsky.social · 17/12/2025
www.linkedin.com/feed/update/...
linkedin.com
We have two chemical biology PhD positions within the CRC 1756 at the University of Vienna to be filled by April 2026. We are mainly looking for chemists with a strong interest in biological… | Thomas...
We have two chemical biology PhD positions within the CRC 1756 at the University of Vienna to be filled by April 2026. We are mainly looking for chemists with a strong interest in biological questions...
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Thomas Boettcher @thomasboettcher.bsky.social · 15/12/2025
Uni Vienna awards 20 postdoctoral positions for 4 years to outstanding female scientists. Our lab boettcher-lab.univie.ac.at participates as host in the field of chemical biology. Eligibility: female, PhD in 2022 or after The E-STEEM call opens on 07.01.2026: careers.univie.ac.at/en/postdoc/e...
careers.univie.ac.at
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Cluster of Excellence 'MicroPlanet' @microbesplanet.bsky.social · 01/12/2025
New @fwf-at.bsky.social CoE Microplanet study from @thomasboettcher.bsky.social lab @univie.ac.at with colleagues from @tumunich.bsky.social introduces High-Level Oxidative Stress (HiLOS) response that enables strong oxidative agents to activate prophages. pubs.rsc.org/en/content/a...
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Cluster of Excellence 'MicroPlanet' @microbesplanet.bsky.social · 10/11/2025
New @fwf-at.bsky.social CoE Microplanet study from @thomasboettcher.bsky.social lab with first author Konstantin Plöchl @univie.ac.at identified a new class of phage blockers, enabling detailed study of phage's role in IBD, diabetes, and infections. pubs.rsc.org/en/content/a...
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Thomas Boettcher @thomasboettcher.bsky.social · 22/11/2025
We are excited to be part of the newly approved SFB contributing from @univie.ac.at to this wonderful collaborative research centre!
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Thomas Boettcher @thomasboettcher.bsky.social · 20/11/2025
Check out our latest work, which got just published in Chemical Science. The study about SOS-independent prophage induction was led by Dr. Magdalena Jancheva: pubs.rsc.org/en/content/a... @univie.ac.at #phages #chemicalbiology #FWF #ERC
pubs.rsc.org
A phage-selective trigger hints at an SOS-independent mechanism of prophage induction by oxidative stress
We identified a prophage-selective induction in poly-lysogenic Staphylococcus aureus induced by certain phenazines, such as pyocyanin, produced by Pseudomonas aeruginosa. Using a focused library of ph...
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Thomas Boettcher @thomasboettcher.bsky.social · 06/11/2025
Our latest research just accepted in RSC Chemical Biology: pubs.rsc.org/en/content/a... In this study led by Konstantin Plöchl from our lab, we report a novel class of small-molecule inhibitors targeting bacteriophage infection. #phages #chemicalbiology @univie.ac.at
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WHO @who.int · 14/10/2025
New WHO report finds 1 in 6 bacterial infections were resistant to antibiotic treatments. Data from over 100 countries warns that rising resistance to essential antibiotics poses a growing threat to global health. Read more 👉bit.ly/438Ta1u
The text reads: “Resistance to antibiotics is widespread and increasing, threatening treatment of common infections. 1 in 6 bacterial infections worldwide were resistant to antibiotics in 2023.”
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Thomas Boettcher @thomasboettcher.bsky.social · 10/09/2025
For our antimicrobial drug development efforts at the University of Vienna we are looking for input from physicians/clinicians who are familiar with treatment, diagnostics, infection control, etc. Your insights would be highly valuable! docs.google.com/forms/d/e/1F...
docs.google.com
Survey on the clinical need for an ultra-narrow spectrum N. gonorrhoeae Antibiotic
Welcome and thank you for participating in this survey! We are the researchers in Boettcher's group at University of Vienna, who are developing the new antibiotic specifically targeting N. gonorrhoeae...
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Thomas Boettcher @thomasboettcher.bsky.social · 04/07/2025
Wonderful work in collaboration with the lab of @davidberry1.bsky.social www.tandfonline.com/doi/full/10....
tandfonline.com
Lactulose selectively stimulates members of the gut microbiota, as determined by multi-modal activity-based sorting
There is much interest in the development of dietary supplements that selectively promote the growth of beneficial gut bacteria. The selectivity of many candidate prebiotics has, however, not been ...
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Thomas Boettcher @thomasboettcher.bsky.social · 28/04/2025
Good to read an informed scientific opinion on this topic. I couldn't agree more. Safety considerations for additives regardless whether synthetic or natural should be only based on scientific data and not on ideology or personal beliefs.
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Thomas Boettcher @thomasboettcher.bsky.social · 22/04/2025
We are looking for an excellent and highly motivated PhD student in Chemical Biology for a position in our group within the AIDD docfunds program @univie.ac.at to investigate anti-infectives from antagonistic microbial interactions. Apply until 03.05.2025: vds-phanuspo.univie.ac.at/application/...
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Thomas Boettcher @thomasboettcher.bsky.social · 20/04/2025
A new cover feature from our lab, designed by first author Viktoriia Savchenko, went online in ACS Chemical Biology. Here is the article link: pubs.acs.org/doi/10.1021/... @univie.ac.at @cemess.bsky.social
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Nature Microbiology @natmicrobiol.nature.com · 04/04/2025
💊🦠OUT NOW - new research showing that 2-nonyl-4-quinolone N-oxide and its 3-methyl derivative kill Neisseria gonorrhoeae in vitro and significantly reduce bacterial numbers in vivo, in mouse infection models #MicroSky www.nature.com/articles/s41...
nature.com
A quinolone N-oxide antibiotic selectively targets Neisseria gonorrhoeae via its toxin–antitoxin system - Nature Microbiology
Pseudomonas aeruginosa-derived 2-nonyl-4-quinolone N-oxide exerts bactericidal effects on Neisseria gonorrhoea via zeta1–epsilon1 toxin–antitoxin activation in vitro and abrogates experimental infecti...
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Nature Reviews Microbiology @natrevmicro.nature.com · 04/04/2025
#weekendreading🔬 A chemical radar allows bacteria to detect and kill predators @cellpress.bsky.social #microsky www.cell.com/cell/fulltex...
cell.com
A chemical radar allows bacteria to detect and kill predators
Pseudomonas syringae can detect and kill microbial predators via a chemical radar (Cra), which also allows the bacterium to infect plants despite predation pressure.
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Thomas Boettcher @thomasboettcher.bsky.social · 02/04/2025
Work of our lab @univie.ac.at in close collaboration with the Hauck Lab @uni-konstanz.de was published in @naturemicrobiol.bsky.social today. A compound highly selective in targeting Neisseria gonorrhoeae using a novel mode of action. @cemess.bsky.social medienportal.univie.ac.at/en/media/rec...
medienportal.univie.ac.at
New antibiotic for multidrug resistant superbug, that causes gonorrhoea
This novel antibiotic activates an existing "suicide" mechanism in gonococci
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Universität Wien / University of Vienna @univie.ac.at · 02/04/2025
Die Zunahme von antibiotikaresistenten Keimen ist ein wachsendes Problem. Dazu gehört etwa der Problemkeim Neisseria gonorrhoeae, der Tripper (Gonorrhö) auslöst. Forscher*innen der Universitäten Konstanz und Wien entdeckten nun eine neue Klasse von Antibiotika, die selektiv dagegen wirken. 💊
medienportal.univie.ac.at
Neues Antibiotikum gegen Problemkeim, der Tripper (Gonorrhö) auslöst
Neuartiges Antibiotikum aktiviert einen in den Gonokokken bereits vorhandenen Selbsttötungsmechanismus
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Universität Konstanz @uni-konstanz.de · 02/04/2025
Research-team of #UniKonstanz + @univie.ac.at have identified a new class of antibiotics that selectively target Neisseria gonorrhoeae—the bacteria behind gonorrhea. Full story: t1p.de/7svjt @naturebicrobiol.bsky.social. Read scientific publication: t1p.de/wtlae
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Cluster of Excellence 'MicroPlanet' @microbesplanet.bsky.social · 02/04/2025
New @fwf-at.bsky.social CoE Microplanet Publication in ASC Chemical Biology from the lab of @thomasboettcher.bsky.social @cemess.bsky.social @univie.ac.at unveils Chitinivorax as a new quinolone-producing genus. Check out the publication ➡ pubs.acs.org/doi/10.1021/...
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Antimicrobial resistance #AMR @antimicrobial.bsky.social · 31/03/2025
Precision medicine for #AMR is making real progress. BiomX's BX211 phage therapy for diabetic foot osteomyelitis (S. aureus) just hit a major milestone in Phase II. Significant ulcer reduction over 91 days. #PhageTherapy #Biotech #InfectiousDisease www.insideprecisionmedicine.com/topics/preci...
insideprecisionmedicine.com
91 Days Later: BiomX’s Phage Fights Off Diabetic Bone Infection in Phase II
CEO Jonathan Solomon explains the significance of BX211—a phage therapy for diabetic foot osteomyelitis—in developing a new precision medicine modality.
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Thomas Boettcher @thomasboettcher.bsky.social · 27/03/2025
Just out now: wonderful work from our lab by lead author Viktoriia Savchenko expanding our knowledge of the diversity of bacteria involved in quinolone biosynthesis, with a newcomer to the family of quinolone producers. #CoE7 @univie.ac.at @cemess.bsky.social #ChemBio pubs.acs.org/doi/10.1021/...
pubs.acs.org
Chitinivorax: The New Kid on the Block of Bacterial 2-Alkyl-4(1H)-quinolone Producers
2-Alkyl-4(1H)-quinolones play a key role in bacterial communication, regulating biofilm formation, and virulence. Their antimicrobial properties also support bacterial survival and interspecies competition in microbial communities. In addition to the human pathogen Pseudomonas aeruginosa various species of Burkholderia and Pseudoalteromonas are known to produce 2-alkyl-4(1H)-quinolones. However, the evolutionary relationships of their biosynthetic gene clusters remain largely unexplored. To address this, we investigated the phylogeny of 2-alkyl-4(1H)-quinolone biosynthetic gene clusters, leading to the discovery of Chitinivorax as a fourth genus capable of producing 2-alkyl-4(1H)-quinolones, expanding our knowledge of the diversity of bacteria involved in quinolone-biosynthesis.
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Thomas Boettcher @thomasboettcher.bsky.social · 21/03/2025
We are happy to be able to advertise a fully funded PhD position in our Lab funded by the FWF DocFunds Program "AIDD-Anti-Infective Drug Discovery"at the University of Vienna in collaboration with the Department of Pharmaceutical Sciences: vds-phanuspo.univie.ac.at/application/...
vds-phanuspo.univie.ac.at
Open positions
Open positions
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Cluster of Excellence 'MicroPlanet' @microbesplanet.bsky.social · 12/03/2025
Tune into this videocast with CoE Microplanet Director of Research @michiwagner4.bsky.social @cemess.bsky.social @univie.ac.at to learn about microbiomes and their connection to health, hygiene, and nutrition. @fwf-at.bsky.social Watch it now: www.youtube.com/watch?v=vz3X... #MicroSky
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cemess_vienna @cemess.bsky.social · 03/03/2025
Big news! Jillian Petersen is now Full Professor at CeMESS – making history as the first female Full Professor at our centre. Huge congratulations, Jill! 🔗 Read more: cemess.univie.ac.at/news/detail-...
cemess.univie.ac.at
Jillian Petersen appointed Full Professor at CeMESS
We are delighted to announce that Jillian Petersen has been appointed Full Professor (§ 99/4) at the Center for Microbiology and Environmental Systems Science (CeMESS). This appointment marks an excit...
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