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Tulsi Upadhyay

@tulsiupadhyay.bsky.social
31 followers 31 following 4 posts

Postdoctoral fellow at Bogyo Lab, Stanford University| Protein Biochemist| Proud IISER Bhopal Alumni

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Tulsi Upadhyay @tulsiupadhyay.bsky.social · 25/06/2025
Excited to share my First GRS and GRC moments. It was very special #Bioorganic GRC2025. Met my PhD advisor @saraogi-ishu.bsky.social. Great Science and networking. Won “Outstanding Poster” award. Thanks to my postdoc advisor @mbogyo.bsky.social for the opportunity to present in GRC with him.
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Tulsi Upadhyay @tulsiupadhyay.bsky.social · 31/05/2025
I'm thrilled to share that my second paper from my postdoctoral work is now published! A heartfelt thank you to my PI, Prof. Bogyo @mbogyo.bsky.social, for his unwavering support throughout this project. I am also deeply grateful to our fantastic collaboration team for making it a great success.🙌
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Reposted by Tulsi Upadhyay
umasschan-bmb.bsky.social @umasschan-bmb.bsky.social · 03/03/2025
🧪 Working to develop #drugs to treat #chikungunya ? Check out new fluorogenic substrates that help read out viral protease activity, developed by @tulsiupadhyay.bsky.social @westberglab.com @eunayoo.bsky.social @michaelzlin.bsky.social et al! pubmed.ncbi.nlm.nih.gov/39981948/
a figure from a scientific paper depicting the fluorescent reporter assay for chikungunya virus protease activity. in places where the protease is inactive, there will be no fluorescent signal due to the physical proximity of the quencher and the donor (linked by a peptide substrate). where the protease is active, the peptide substrate will be cleaved and will free the donor from the influence of the quencher and thus produce a fluorescent signal upon excitation.
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Reposted by Tulsi Upadhyay
Matt Bogyo @mbogyo.bsky.social · 25/02/2025
Amazing work by @sijiewang.bsky.social and our collaborators is out in JACS today. Interested in covalent inhibitors of protein-protein interactions? Check it out. pubs.acs.org/doi/10.1021/...
pubs.acs.org
Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein–Protein Interactions Using Phage Display
Peptide macrocycles are promising therapeutics for a variety of disease indications due to their overall metabolic stability and potential to make highly selective binding interactions with targets. R...
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Reposted by Tulsi Upadhyay
Christian Lentz @christianslentz.bsky.social · 11/02/2025
New article out in ACS Infectious Diseases! Using activity-based probes by H. Overkleeft, former PhD candidate @jalal228.bsky.social identified an alpha-amylase family protein of S. aureus supporting virulence during Galleria infection! @monaj66.bsky.social pubs.acs.org/doi/10.1021/...
pubs.acs.org
Activity-Based Protein Profiling Identifies an α-Amylase Family Protein Contributing to the Virulence of Methicillin-Resistant Staphylococcus aureus
In search of new putative antimicrobial drug targets in methicillin-resistant Staphylococcus aureus, we aimed to identify and characterize retaining glycosidase activities in this bacterial pathogen. ...
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Reposted by Tulsi Upadhyay
Matt Bogyo @mbogyo.bsky.social · 27/02/2025
Another big publication from @sijiewang.bsky.social this week. Check out our efforts to use mRNA display to screen for covalent binding inhibitors of Staphylococcus aureus serine hydrolases. pubs.acs.org/articlesonre...
pubs.acs.org
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Reposted by Tulsi Upadhyay
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 10/01/2025
Cool new preprint from @stanford-chemh.bsky.social fellow @mbogyo.bsky.social @stanfordmedicine.bsky.social www.researchsquare.com/article/rs-5...
researchsquare.com
Covalent-fragment screening identifies selective inhibitors of multiple Staphylococcus aureus serine hydrolases important for growth and biofilm formation
Staphylococcus aureus is a leading cause of bacteria-associated mortality worldwide. This is largely because infection sites are often difficult to localize and the bacteria forms biofilms which are n...
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Tulsi Upadhyay @tulsiupadhyay.bsky.social · 10/01/2025
Excited to repost the news on this new platform!! Great collaborative work under the mentorship of @mbogyo.bsky.social is out for your read.
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