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Chalystha Lee

@chalysthalee.bsky.social
207 followers 574 following 18 posts

🇲🇾 in 🇦🇺, and now 🇺🇸🗽 | postdoc @ nyu | Interested in how the brain in our gut works! 👩🏻‍🔬 @margolislabnyu.bsky.social

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Reposted by Chalystha Lee
NYU Pain Research Center @nyupainresearch.bsky.social · 16/09/2026
Great to have Dr. Ishmail Abdus-Saboor visit the PRC today! It was exciting to hear about his work on the skin-brain axis and to spend the day talking science. Thank you @ishmailsaboor.bsky.social!
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MargolisLab @margolislabnyu.bsky.social · 11/08/2026
🎉 Beyond proud to celebrate Dr. Margolis in receiving the ANMS Distinguished Investigator Award for Women in Neurogastroenterology! 🏆 A well-deserved honor celebrating her groundbreaking research and incredible mentorship! 💙 @karapedsgastrodoc.bsky.social @nyupainresearch.bsky.social
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Reposted by Chalystha Lee
NYU Pain Research Center @nyupainresearch.bsky.social · 09/07/2026
NEW PRC PAPER 🚨: The Jensen lab discovered that the human itch receptor MrGPRX1 traffics to the endosomal network, where it continues to signal and drive TRPV1 sensitization. Congratulations to first author @pazduran.bsky.social and the whole team! www.frontiersin.org/journals/mol...
frontiersin.org
Frontiers | Endosomal MrGPRX1 signaling sensitizes TRPV1 to enhance itch
G protein-coupled receptors (GPCRs) and TRPV (transient receptor potential vanilloid) channels are crucial for signal transduction in physiological processes...
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MargolisLab @margolislabnyu.bsky.social · 17/06/2026
🎉 Congratulations to Chalystha and Rahi from the Margolis Lab on their achievements at the 2026 Annual Molecular Pathobiology Innovative Research Symposium (AMPIRS)! Chalystha won 3rd Place for her 3-minute flash talk Rahi won 3rd Place for her poster presentation @karapedsgastrodoc.bsky.social
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NYU Pain Research Center @nyupainresearch.bsky.social · 17/06/2026
NEW PRC PAPER 🚨 from Nestor Jimenez-Vargas and the Bunnett Lab reveals how elevated proteases and histamine drive IBS visceral pain, showing that a prolonged intracellular PAR2 receptor signaling loop keeps the H1 receptor active to continuously amplify and maintain pain. gut.bmj.com/content/earl...
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Reposted by Chalystha Lee
Jeff Markowitz @vulcnethologist.bsky.social · 16/06/2026
Come work with us! We're looking for a new lab manager to help us develop new motion capture methods, new biosensors, and to hopefully learn something cool about the brain. Bonus: you get to do all this in the ATL and, in my humble opinion, we're nice people to work with! markolab.org/careers/
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NYU Pain Research Center @nyupainresearch.bsky.social · 08/05/2026
Very proud to share this @usasp.bsky.social podcast episode featuring PRC postdoc Elisa Damo @elisadamo.bsky.social, one of the Top 5 Travel Awardees from the USASP Annual Scientific Meeting! @karapedsgastrodoc.bsky.social soundcloud.com/usasp/episod...
soundcloud.com
34. 2026 USASP Annual Meeting Top 5 Trainee Travel Awardees
Listen to the top five travel awardees from the 2026 USASP Annual Meeting which took place from March 23-26, 2026 in Philadelphia, Pennsylvania. In this episode, we will learn on the current work fro
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Reposted by Chalystha Lee
NYU Pain Research Center @nyupainresearch.bsky.social · 27/05/2026
We are thrilled to bring together the NYU pain research community at our symposium tomorrow! Looking forward to a day of exciting science, connection, and collaboration.
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NYU Pain Research Center @nyupainresearch.bsky.social · 28/05/2026
Amazing day so far at the PRC symposium! So much exciting science from our research community and awesome keynote speakers. @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @sarahanajjar.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social
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NYU Pain Research Center @nyupainresearch.bsky.social · 29/05/2026
More shots from our PRC Symposium yesterday. We were grateful to host wonderful keynote speakers: Dr. Walter Koroshetz, Dr. Lin Chang, Dr. Jeffrey Hubbell, and Dr. Ru-Rong Ji! @karapedsgastrodoc.bsky.social
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Chalystha Lee @chalysthalee.bsky.social · 29/05/2026
Congratulations, Mariam!!! Such a pleasure having you in the lab!
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Reposted by Chalystha Lee
MargolisLab @margolislabnyu.bsky.social · 29/05/2026
Highlights from the 2026 Pain Research Center Symposium! Dr. Kara Margolis presented: “Compartmental Serotonergic Signaling in Gut–Brain Health: Clinical Implications for Mood and Abdominal Pain” Thanks to everyone for a great day of science! @karapedsgastrodoc.bsky.social
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Reposted by Chalystha Lee
MargolisLab @margolislabnyu.bsky.social · 29/05/2026
The Margolis Lab was proud to be represented by six poster presenters at the 2026 Pain Research Center Symposium! Congratulations to: Sarah, Daniel, Chalystha, Lin, Rahi, Taeseon Great job to everyone who presented and contributed to a fantastic day of science! @karapedsgastrodoc.bsky.social
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MargolisLab @margolislabnyu.bsky.social · 29/05/2026
More highlights from our amazing team at the NYU Pain Research Center Symposium! We're proud of our team's contributions and grateful for a fantastic day of science, collaboration, and discovery.
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Chalystha Lee @chalysthalee.bsky.social · 22/05/2026
Congratulations Haoming!!!
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Reposted by Chalystha Lee
Eric Topol @erictopol.bsky.social · 20/04/2026
We've known the gut-brain axis is a key underpinning of Parkinson's disease. Today, for the 1st time, a gut microbiome signature denoting risk found in healthy individuals with genetic predisposition nature.com/articles/s41...
nature.com
Microbiome signature of Parkinson’s disease in healthy and genetically at-risk individuals - Nature Medicine
Microbiome analysis suggests that gut microbial changes in Parkinson’s disease evolve progressively from healthy individuals to genetically at-risk individuals to clinically affected patients, with th...
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MargolisLab @margolislabnyu.bsky.social · 02/04/2026
In our latest study, we explore how early experiences can shape gut function and pain later in life. Dr. @sarahanajjar.bsky.social breaks it down 👇
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Chalystha Lee @chalysthalee.bsky.social · 02/04/2026
Well deserved, @linyhung.bsky.social!!!!! 🥳🥳🥳
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Chalystha Lee @chalysthalee.bsky.social · 11/02/2026
Look who stopped by NYC from across the globe! Felt like worlds colliding having my PhD PI @elimelb.bsky.social and postdoc PI @karapedsgastrodoc.bsky.social in the same room. So fitting on Intl Day of Women&Girls in Science to celebrate two brilliant women who paved the way for me!
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GutTalkMd @karapedsgastrodoc.bsky.social · 16/12/2025
Happy holidays from the Margolis lab! Pic after a hard core karaoke party😂
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Deutsche Gesellschaft für Neurogastroenterologie & Motilität @dgnm.bsky.social · 01/11/2025
👉 We generated a starter pack for #neurogastroenterology and enteric #neuroscience! Let's connect and bring gut-brain research and clinical neurogastroenterology to the next level! 🌐 go.bsky.app/3Z82PbH
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NYU Pain Research Center @nyupainresearch.bsky.social · 10/09/2025
The Margolis Lab had a great time at #ANMS2025 in Minneapolis! Postdocs Sarah, Lin & Chalystha gave abstract talks, PRC Director Kara closed the conference, and we met Keynote Speaker & 2021 Nobel Laureate David Julius and his team! #ANMS225
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NYU Pain Research Center @nyupainresearch.bsky.social · 10/09/2025
PRC Highlight: #MargolisLab making strides again! Congrats to Chalystha Lee who received the 2025 ISSR Travel Award at the #ISSR2025 hosted in Vienna! With mentorship from Dr. Kara Margolis & Dr. Michael Gershon lighting the way. #mentorship #ISSR #womeninresearch @chalysthalee.bsky.social
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Nesia Zurek, PhD @docnessmonster.bsky.social · 07/08/2025
Gabapentin is widely prescribed for nerve pain, but it doesn’t work the same for everyone. We studied actual human sensory neurons from donors and found that some responded strongly - and others hardly at all. #fromlabtolife #neuroskyence #PainResearch 1/4
Alt text (expanded version for web or accessibility-focused platforms):
Vertical infographic titled “Why Gabapentin Works Differently for Different People.”
Section 1 explains that 10% of adults live with neuropathic pain and gabapentin doesn't help everyone.
Section 2 shows that researchers used donated human dorsal root ganglia (DRG) neurons to study gabapentin’s effects, combining electrophysiology and RNA sequencing.
Section 3 illustrates how gabapentin reduced excitability in some donors’ neurons but not others, and those differences matched gene expression profiles.
Section 4 highlights how this could lead to more personalized pain treatment that adds life to the years of people living with chronic pain.
Footer credits the donors and includes the study DOI
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Chalystha Lee @chalysthalee.bsky.social · 15/07/2025
Just back from a great week in Vienna for #ISSR2025. I am grateful for the travel award and the opportunity to share my work. Big thanks to @karapedsgastrodoc.bsky.social and Mike Gershon for their steady support in the lab and my career. Loved connecting with 5-HT researchers from around the world!
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Chalystha Lee @chalysthalee.bsky.social · 08/07/2025
@karapedsgastrodoc.bsky.social gave a fantastic talk on the lab's important work on SSRI use in the gastrointestinal tract @margolislabnyu.bsky.social highlighting @linyhung.bsky.social and @sarahanajjar.bsky.social 's work! @nyupainresearch.bsky.social
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Chalystha Lee @chalysthalee.bsky.social · 08/07/2025
Excited to learn about all things Serotonin / 5HT at #ISSR2025 in Vienna!
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Pain Research Forum @painresforum.bsky.social · 30/06/2025
What do you think these #painresearch results from Ullrich et al. in Science Advances may mean for finding the patterns behind ligand bias? bit.ly/4elhYYE
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NYU Pain Research Center @nyupainresearch.bsky.social · 31/05/2025
And just like that, AMPIRS takes its final bow! 🎬Huge cheers to our grand finale presenters and a confetti cannon 🎉 of congrats to all the Flash Talk, Poster and Oral Presentation champs! 🏆 You dazzled, you delivered, you definitely deserve it! #PRCpride #MPBpride
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Chalystha Lee @chalysthalee.bsky.social · 11/06/2025
Congratulations @tonelloraquel.bsky.social and @mariafialho.bsky.social !! Fantastic work!
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Chalystha Lee @chalysthalee.bsky.social · 03/06/2025
Congratulations @sarahanajjar.bsky.social & @linyhung.bsky.social !! 🙌🥳
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Ted Price @tedpricethepainguy.bsky.social · 14/05/2025
BOOM! www.nature.com/articles/s41... I think this is a big step forward for the field. Congrats to Lauren Donovan and @vivtawfik-mdphd.bsky.social and the whole Tawfik lab team.
nature.com
Aging and injury drive neuronal senescence in the dorsal root ganglia - Nature Neuroscience
The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.
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Emilia Favuzzi @emiliafavuzzi.bsky.social · 22/05/2025
I am looking for a postdoc with an immunology background interested in joining a Yale neuroscience lab to study how the brain controls immunity. At Yale, we have a wonderful interdisciplinary & collaborative #neuroimmune community. Please reach out or share with anyone who might be interested!
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Kuchroo Lab @kuchroolab.bsky.social · 23/05/2025
🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱. 🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org www.science.org/doi/10.1126/...
science.org
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense
Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...
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NYU Pain Research Center @nyupainresearch.bsky.social · 21/05/2025
Congrats to @karapedsgastrodoc.bsky.social on becoming part of the 2025 AGA Council section leaders!! Read more👉 gastro.org/news/meet-ou...
gastro.org
Meet our 2025 AGA Council section leaders
Introducing the five members elected to join the AGA Institute Council and lead specialty-based sections.
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Chalystha Lee @chalysthalee.bsky.social · 12/04/2025
Definitely something important to consider wrt our studies in rodent preclinical models!
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tBerta Lab @tbertalab.bsky.social · 08/04/2025
🔬 Exciting discovery! We've been curious about the function of unique IBA1+ cell staining we observed around healthy human DRG neurons in the lab (indicated by red arrows). A new paper @cellpress.bsky.social finally provides some answers. Link: www.cell.com/cell/fulltex...
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Lauren Atlas @laurenatlas.bsky.social · 07/04/2025
We have slots for 2-3 postbacs! Get in touch if you’re interested in joining the Affective Neuroscience and Pain lab & contributing to our studies of pain, emotion, and social processing in the 🧠
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Gemma C. Atkinson @gemmaatkinson.bsky.social · 08/04/2025
last day to apply for a post-doc position in my group #phagesky #microsky
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Patrik Ernfors @patrikernfors.bsky.social · 24/03/2025
How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study. www.nature.com/articles/s41...
nature.com
Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord - Nature Neuroscience
Zhang et al. identify unimodal neural representations in the spinal cord of cutaneous mechanical and heat stimuli gated by a shared feed-forward local inhibitory neuron type and a neural transition du...
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NYU Pain Research Center @nyupainresearch.bsky.social · 20/03/2025
CONGRATULATIONS to Drs. Sarah Najjar, Lin Hung and Kara Margolis- Their review article: Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation is one of the top 10 most cited articles published in 2023! onlinelibrary.wiley.com/doi/abs/10.100… 🥳🔝🔟
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Ted Price @tedpricethepainguy.bsky.social · 19/03/2025
Our program manager extraordinaire, Ayesha Ahmad, is leaving us, so we have an exciting position open to take on her role. jobs.utdallas.edu/postings/28956 In addition to this being an exciting position, you will also get to learn from Ayesha before she departs.
jobs.utdallas.edu
Program Manager I
This position will be responsible for managing and overseeing the day-to-day operations of the Human Nociceptor and Spinal Cord Molecular Signature Center under the direction of Dr. Ted Price. Key dut...
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Joana F Neves @nevesjf.bsky.social · 03/03/2025
Looking for an excellent & highly motivated postdoctoral researcher to join our team to develop an exciting project focused on the generation of beneficial Innate Lymphoid Cells #ILC for the treatment of Inflammatory Bowel Disease #IBD using #organoids. Please share! www.kcl.ac.uk/jobs/109186-...
kcl.ac.uk
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Chalystha Lee @chalysthalee.bsky.social · 05/03/2025
So excited to share what I've been up to in the past year at the 2025 Serotonin Meeting in Vienna! Can't wait for July! Thank you ISSR for this travel grant! @margolislabnyu.bsky.social
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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 03/03/2025
#GastroEdPick Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid @naturemicrobiol.bsky.social www.nature.com/articles/s41...
nature.com
Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid - Nature Microbiology
Intestinal crypt-resident Acinetobacter radioresistens secretes indole acetic acid which activates an Ahr-Wnt-β-catenin-EphB2 signalling axis to promote intestinal stem cell homeostasis and prevent tu...
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MargolisLab @margolislabnyu.bsky.social · 27/02/2025
🎉 Celebrating Mike Gershon, the father of Neurogastroenterology and an amazing mentor! 🧠💡 Happy Birthday, Mike! 🎂🥳 @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @chalysthalee.bsky.social @linyhung.bsky.social @taeseonwoo.bsky.social @erfanehbarati.bsky.social
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Catherine Dulac @dulaclab.bsky.social · 26/02/2025
Our latest findings on social behavior circuits is out: how does the brain responds to social isolation? Terrific work by @dingliu.bsky.social et al. uncovering a circuit with similar neural architecture as physiological needs (hunger, thirst, sleep..). Detailed thread soon. rdcu.be/ebo63
rdcu.be
A hypothalamic circuit underlying the dynamic control of social homeostasis
Nature - New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social...
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Marie Carlén @carlenlab.bsky.social · 24/02/2025
We are hiring a research assistant! Come join our ongoing project investigating the PFC-striatum pathway in cognitive flexibility. Head-fixed behavior, Neuropixels, optogenetics, and viral circuit tracing etc ki.varbi.com/en/what:job/.... Please spread.
ki.varbi.com
Research Assistant in Neuroscience
Do you want to contribute to top quality medical research? The position regards experimental research in the laboratory of Professor Marie Carlén in the Department of Neuroscience. Utilizing a sy
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NYU Pain Research Center @nyupainresearch.bsky.social · 19/02/2025
@tedpricethepainguy.bsky.social @utdpaincenter.bsky.social Great visit today from Dr. Ted Price! Thank you for wowing us with your team’s exciting data on human DRG tissue, very inspiring and insightful seminar! #painresearch #dorsalrootganglia #humanDRG #nyudental #nyuniversity #nyupainresearch
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Ardem Patapoutian @ardemp.bskyverified.social · 06/02/2025
“You can’t discover what you don’t study.” @jennifergarrison.bsky.social highlights the need for more focus on women’s health at the Merkin Symposium at Caltech. Hard for anti-diversity folks to argue against addressing health issues that impact half the population…
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