The NGF/TrkA signaling axis is a central mediator of inflammatory and chronic pain, where injury-induced NGF binds and activates TrkA on nociceptive neurons to drive peripheral sensitization and persi...

Endocytosis replenishes synaptic vesicle (SV) pools that are required for persistent transmission of chronic pain signals within nociceptive spinal circuits. The nociceptor-specific contribution of SV...

Listen to the top five travel awardees from the 2026 USASP Annual Meeting which took place from March 23-26, 2026 in Philadelphia, Pennsylvania. In this episode, we will learn on the current work fro

Summary Recent research highlights neuropilin-1 (NRP1) as a critical co-receptor for nerve growth factor (NGF) and TrkA signaling in pain mechanisms. While NGF monoclonal antibodies have shown promise...