Brandow et al. describe how the gut microbiome drives chronic sickle cell disease (SCD) pain. SCD guts contain excessive heme catabolites, fewer bacteria that metabolize bilirubin, and low levels of A...

Expression and functional analysis define how Piezo1-dependent cholinergic responses by enteric neurons directly sense luminal pressure to orchestrate digestion and inflammation in mice.

Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

The brain senses changes to the internal state of the body, eliciting responses that maintain homeostasis. Alhadeff and Yapici provide an overview of this process, termed interoception, with a particu...

Visceral pain is a major clinical issue, most commonly associated with gastrointestinal disorders. This Review discusses molecular mechanisms by which neurons are sensitized in the gut, outlining sign...