This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in h...

Th17 cells can either preserve homeostasis or drive inflammation in tissues; however, the mechanisms that maintain homeostatic phenotypes are not well defined. Yang et al. uncover a cell-intrinsic glucocorticoid circuit and the underlying gene network by which it maintains homeostasis in Th17 cells. They find that TGF-β1 can reverse the glucocorticoid resistance exhibited by both murine and human inflammatory Th17 cells.

Astrocytes promote central nervous system (CNS) immunity through antigen presentation and activation of CD40 in astrocytes by CD40L expressed by CD4+ T cells in a model of experimental autoi...

Th17 cells can either preserve homeostasis or drive inflammation in tissues; however, the mechanisms that maintain homeostatic phenotypes are not well defined. Yang et al. uncover a cell-intrinsic glu...

Th17 cells can either preserve homeostasis or drive inflammation in tissues; however, the mechanisms that maintain homeostatic phenotypes are not well defined. Yang et al. uncover a cell-intrinsic glucocorticoid circuit and the underlying gene network by which it maintains homeostasis in Th17 cells. They find that TGF-β1 can reverse the glucocorticoid resistance exhibited by both murine and human inflammatory Th17 cells.

How IL-23 drives an inflammatory Th17 cell state is poorly understood. Yang et al. identify two coordinated mechanisms specific to IL-23R signaling: the recruitment of CHD1 to stabilize RORγt expression and function and the blockade of glucocorticoid receptor function. Their study explains how IL-23 locks Th17 cells into an inflammatory disease-promoting state and provides a mechanism that explains steroid resistance in Th17 cells.

B cells are a critical adaptive immune cell type in the development of TH17 cell–mediated experimental autoimmune encephalomyelitis.

Mass General Brigham researchers engineered a virus that destroys brain tumor cells while avoiding healthy brain tissue.

The importance of peripheral immunity in Alzheimer disease has gained much traction in recent years, mainly due to multiple genome-wide association studies identifying risk loci associated with genes ...

Enteric neurons are essential regulators of intestinal physiology, yet their responses to varying microbial and immune environments along the intestinal tract and or during challenges remain poorly un...

RAMP3, a component of the receptor for the neuropeptide CGRP, has a cell-intrinsic role in T helper type 1 cell fate determination.

Findings, based on mouse studies, could pave the way for more effective cancer treatments

The glycolytic enzyme phosphoglycerate mutase supports Treg function, identifying a novel therapeutic target for immune modulation and demonstrating that glycolytic regulation of T cells is more nuanc...

Glucose metabolism is a critical regulator of T cell function, largely thought to support their activation and effector differentiation. Here, we inve…

Wang et al. identify phosphoglycerate mutase (PGAM) as a negative regulator of pathogenic Th17 cell differentiation, contrary to other glycolytic enzymes. PGAM inhibition suppresses a regulatory progr...

Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...

Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...