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Chronic back pain (CBP) affects one in ten people worldwide, limiting mobility, productivity, and quality of life. Current treatments are often inadequate, partly due to an incomplete understanding of...

Noxious mechanical stimuli give rise to distinct percepts, from sharp cutaneous pain to diffuse visceral discomfort, yet the nociceptor ensembles that underlie these differences remain poorly defined....

The NGF/TrkA signaling axis is a central mediator of inflammatory and chronic pain, where injury-induced NGF binds and activates TrkA on nociceptive neurons to drive peripheral sensitization and persi...

IntroductionChronic itch is a major burden, impacting the quality of life for one in four adults, and is closely associated with increased levels of anxiety,...

G protein-coupled receptors (GPCRs) and TRPV (transient receptor potential vanilloid) channels are crucial for signal transduction in physiological processes...

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

Chronic pain exhibits circadian rhythms in humans, but the mechanisms underlying such rhythmicity remain unclear. Here, we found daily oscillations in the nociceptive thresholds in a mouse model of…

In mice, a circuit between the spinal cord and various regions of the brain, centring on spinal-cord-projecting neurons in the rostral ventromedial medulla, has a key role in driving chronic pain.

Sensory neuron subtypes are defined by transcriptomics, but their proteomic identities remain unclear. Here, authors show distinct protein signatures of electrophysiologically defined nociceptors and…

Listen to the top five travel awardees from the 2026 USASP Annual Meeting which took place from March 23-26, 2026 in Philadelphia, Pennsylvania. In this episode, we will learn on the current work fro

Peripheral monocytes and IL-10 are associated with shorter pain duration in males in both mice and humans.

Su et al. show that inflammatory arthritis pain stems from sustained interferon-driven MNK1/MNK2–elF4E signaling that sensitizes joint-innervating neurons. Blocking this pathway reverses pain, suggest...