By Dr. Douglas R. Waverly, Professor Emeritus of Biochemistry, Yale University

Academic Position in Neuromodulation Research, Department of Psychiatry, Cumming School of Medicine in Calgary, ...

Ouellette et al. report that a 16p11.2 deletion induces a bioenergetic failure in brain endothelial cells. Activation of purinergic signaling via P2Y2 receptors restored endothelial function and impro...

Assistant Professor - Systems Neurophysiology

The hypothalamus is a central regulator of glucose and energy homeostasis, with arcuate nucleus (ARC) neurons orchestrating these processes. Agouti-related peptide (AgRP) and pro-opiomelanocortin (POM...

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Fear learning increases the similarity of threatening and neutral context representations in ventral CA1, which may enable faster reinstatement of threat memories, compared to dorsal CA1.

Association canadienne des neurosciences

The country singer was an advocate for vaccines, public health, literacy and marginalized communities.

Astrocytes are the most numerous brain cells and are central to the regulation of brain metabolism. Here, we present a protocol for identifying molecular signatures and assessing the metabolic functio...

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Growing evidence shows that dopamine signaling is diverse, with dopaminergic neurons responding to rewarding and aversive stimuli. Here, we hypothesiz…

This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in h...

Molecular profiling of myeloid cells from the prefrontal cortex of 1,607 donors with varying degrees of Alzheimer’s disease neuropathology delineates distinct myeloid subtypes and identifies changes associated with aging and disease progression.

Neurons have long taken top billing in memory, but researchers are making the case for astrocytes.

Early-life stress (ELS) sensitizes individuals to subsequent stressors to increase lifetime risk for psychiatric disorders. Within the nucleus accumbens (NAc) — a key limbic and reward-associated brai...

Immune surveillance of the central nervous system (CNS) is regulated by the brain barriers. Antigen presentation at the blood–brain barrier (BBB) has been proposed to promote antigen-specific T-cell e...

Kim, Geiger et al. report that early-life stress increases the chromatin modification H3K4me1 and its enzymatic writer, SETD7, in the ventral tegmental area. They show that this form of epigenetic pri...

Join IBRO in electing new members of its five Regional Committees. IBRO's Governing Council can submit their proposal by 15 Aug 2026.

uOttawa, in partnership with the OHRI, invites applications for a Tier 2 CRC in Vascular Links to Neurodevelopment and their impact on brain health.

Cell Death & Disease - Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood-brain barrier disruption