Cell Death & Disease - Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood-brain barrier disruption

Focal stroke leads to complex changes in the cerebral microcirculation in surviving brain tissues that strongly influence recovery. Plasminogen activator inhibitor-1 (PAI-1; encoded by Serpine1) is hi...

A study in mice identified the cytokine IL-10 as a key culprit in diabetes-associated vascular damage in the brain and cognitive deficits

Passage of molecules across the central nervous system is tightly regulated by the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB), which restrict entry of many substances, including op...

Transient stoppages of red blood cell (RBC) flow through capillaries—termed capillary stalls—occur persistently in neurological disorders such as Alzheimer’s di...

A neuroscience graduate whose research focuses on improving the recovery of stroke survivors has been awarded best master’s thesis at the University of Victoria. Kamal Narayana received the Lieutenant...

Focal stroke leads to complex neurological disturbances with variable recovery. One explanation for this variability is that stroke disrupts local and remote ne...

Sustained labeling of fluids is crucial for their investigation in animal models. Here, we introduce a mouse line (Alb-mSc-ST), where blood and interstitial fluid are labeled with the red fluorescent ...

Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

Vandal et al. performed a biological sex-based study on the role of the Alzheimer’s disease (AD) genetic factor CD2AP in brain blood vessels. Using mouse models and human AD samples, they identified a...

Communications Biology - Lifestyle matters for genetic Alzheimer’s disease risk: In vivo imaging of mouse blood vessels and neurons shows that APOE4 reduces neurovascular function most in an...

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As the population ages, neurovascular pathologies have become leading causes of death and disability. Santisteban and Iadecola review data showing that neurovascular aging not only reduces cerebral blood flow but also impairs protein clearance, immune function, and neurotrophic homeostasis, thereby increasing the risk of stroke, vascular dementia, and Alzheimer’s disease.

Whole-brain anatomical and activity surveys identify the lateral hypothalamus as a key driver of recovery from spinal cord injury, leading to a deep brain stimulation therapy that augments the recover...

The angiogenic capacity of the mature healthy brain and its underlying mechanisms are unclear. Raudales et al. show that rates of cerebral angiogenesis follow regional gradients and are regulated by e...

Established methods for imaging the living mammalian brain have, to date, taken the brain’s optical properties as fixed; we here demonstrate that it is possible to modify the optical properties of the...

This popular, free online microscopy course begins with basics of optics, proceeds through transmitted light microscopy, and covers many microscopy methods.

Interleukin-10 promotes the formation of microcirculatory defects in the brain associated with cognitive impairment in a mouse model of type 1 diabetes.