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Ule Lab @ulelab.bsky.social · 24/01/2026

Congrats Iosifina and Paulo, great team work!

Reposted by Ule Lab

Kurianlab @kurianlab.bsky.social · 24/01/2026

www.nature.com/articles/s41... Polyamines in the regulation of splicing (and potentially transciption dynamics) From Carracedo lab. Really cool to see this. Time to figure out polyamines control molecular homeostasis, especially in the context of aging

nature.com

Polyamine-dependent metabolic shielding regulates alternative splicing - Nature

Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.

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Reposted by Ule Lab

Plaschka lab @plaschkalab.bsky.social · 21/11/2025

How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)

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Ule Lab @ulelab.bsky.social · 24/09/2025

Collective challenges need collective solutions. Happy to share the insights we've gained from the way our cells handle this: www.nature.com/articles/s41... and its summary www.crick.ac.uk/news/2025-09....

lnkd.in

This link will take you to a page that’s not on LinkedIn

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Ule Lab @ulelab.bsky.social · 19/03/2025

Very pleased to share this new preprint from our group, uncovering how alternative polyadenylation is regulated by arginine methylation: PRMT activity promotes global 3’ UTR shortening in proliferating cells www.biorxiv.org/content/10.1...

biorxiv.org

PRMT activity promotes global 3’ UTR shortening in proliferating cells

Protein methyltransferase (PRMT)-catalysed arginine methylation is a widespread post-translational modification that regulates numerous RNA-binding proteins and frequently becomes dysregulated in canc...

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Reposted by Ule Lab

Soazig Le Bihan @soaziglebihan.bsky.social · 22/12/2024

Carlos Santana (UPenn) argues that optimal openness is not maximum openness. Openness is one of the core values that govern science. Trade offs apply depending on contexts. #ScienceAndValues #philsci #philsky

cambridge.org

The Value of Openness in Open Science | Canadian Journal of Philosophy | Cambridge Core

The Value of Openness in Open Science

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