If everybody cycled like the Dutch, we could offset the UK or Australia’s entire carbon footprint.

Steroid-resistant acute graft-versus-host disease is set at disease onset and leads to distinct cell-to-cell cross-talk and immune trajectories.

The skin cells of tanning bed users have distinct mutational features as compared to people who only experience natural sunlight.

Real-world data suggest that SARS-CoV-2 mRNA vaccines, administered within 100 days of immune checkpoint inhibitor (ICI) treatment (“peri-ICI vaccination”), may improve ICI effectiveness, potentially ...

We are seeking a postdoctoral Research Associate to work on an exciting new multi-disciplinary project studying B-cell acute lymphoblastic leukaemia (B-ALL). The project is a collaboration between Dr

Claims that the gut microbiome causally contributes to autism regularly appear in the scientific literature and popular press. Mitchell et al. critically examine influential studies underpinning these...

Researchers at the MRC Translational Immune Discovery Unit have identified how rare populations of abnormal cells drive the formation and persistence of fistulas - painful, tunnel-like tracts that dev...

Cytomegalovirus (CMV) infection leaves lasting effects on the immune system, particularly shaping T-cell populations. In patients with advanced cancer, persistent CMV exposure may influence vaccine re...

This review discusses the role of chronic human cytomegalovirus (HCMV) infection in patients receiving immune checkpoint blockade (ICB) treatment against different malignancies, with an especial focus on malignant melanoma. We briefly outline the impact ...

An analysis of TCGA whole-genome sequencing samples yields a comprehensive resource for investigating the role of microbes in cancer.

Our understanding of variation in monocyte context-specific splicing and transcript usage is limited. Here, the authors find genetic variants that affect gene splicing in monocytes in specific co...

Here, we investigate why liver metastases reduce the efficacy of immune checkpoint inhibitors (CPI). The poor prognosis of patients with liver metastases is associated with a systemic increase in neut...

Our understanding of variation in monocyte context-specific splicing and transcript usage is limited. Here, the authors find genetic variants that affect gene splicing in monocytes in specific contexts, including several diseases, and in response to stimulants.

Immune checkpoint blockade influences the genetically determined relationship between TCR repertoire and HLA alleles in cancer.

The REX element is associated with long-range enhancer–promoter interactions.

The recent attack on science in the US is not only undermining knowledge; it is also undermining democracy. In a healthy democracy, public policy is guided by evidence, and truth is the shared foundat...

Click on the article title to read more.

For Black people, surviving skin cancer begins with knowing what to look for — and where to look.

CREBBP mutations in B-cell acute lymphoblastic leukemia (B-ALL) are linked to poor prognosis and chemoresistance. Here, the authors show that genetic or pharmacological inactivation of CREBBP sensitiz...

Let’s not shoot ourselves in the foot again.

Lieping Chen describes how his discoveries with PD-L1 yielded life-saving treatments for several cancers.

Colorectal cancer incidence rates vary geographically and have changed over time¹. Notably, in the past two decades, the incidence of early-onset colorectal cancer, affecting individuals un...

Experiments in mouse models show that proper recovery of the intestinal microbiota following depletion, with or without faecal microbiota transplant therapy, is dependent on syntrophic interactions th...