Hunter Shain @shainlab.bsky.social · 03/09/2026Clippers get the harshest punishment for a team in NBA history. Kawhi Leonard's uncle get banned from the NBA. Meanwhile Kawhi Leonard is not suspended and he keeps 20 million in laundered money? How does this dude get off scot-free? 010
Hunter Shain @shainlab.bsky.social · 25/08/2026Why can't water-intensive agriculture be moved to places with water? Grow the alfalfa in Texas and ship it cattle in the Colorado river basin. Every other natural resource has figured out how to distribute itself through supply chains. 001
Hunter Shain @shainlab.bsky.social · 19/08/2026My recommendation to CSR... If a grant mechanism has a single digit success rate, allow the applicants to submit Human Subjects and Vertebrate Animals with their JIT documents instead of with the full application. 000
Hunter Shain @shainlab.bsky.social · 15/08/2026I’m noticing an uptick in desperate emails seeking volunteer labor from faculty. It feels like a symptom of the soft-money system reaching its breaking point. What’s striking is how often list-wide requests for unpaid faculty effort go out before remuneration is even considered. 010
Hunter Shain @shainlab.bsky.social · 30/07/2026I love drafting detailed budgets and inclusion/enrollment reports for grants with a 6% funding rate! 000
Hunter Shain @shainlab.bsky.social · 29/07/2026The regulatory burden for awards with a less than 10% success rate is a pure waste. Initial submissions should just be aims and research strategy. Invite discussed applications to submit all the other stuff in a 2 week window after learning that they will be discussed. 020
Hunter Shain @shainlab.bsky.social · 27/07/2026I think this is actually good. Application length more than doubles with all these boilerplate letters 000
Hunter Shain @shainlab.bsky.social · 23/07/2026Move over zebrafish. Welcome catfish. The newest model organism in the melanoma field. www.nature.com/articles/s41...nature.comBrown bullhead catfish melanoma represents a novel transmissible cancer - NatureWhole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer. 020
Hunter Shain @shainlab.bsky.social · 23/07/2026I am being asked to review a lot of papers/grants on topics where I have not published yet, but I do have active research. My theory is that AI is recommending me to editors. If correct, it is creepy that it seems to know so much about our behind-the-scenes work 000
Hunter Shain @shainlab.bsky.social · 23/07/2026I was just asked to review. The mail came from a "no-reply@" address. The only way to decline was to create a 2-factor login, fill in a dozen required fields, and navigate through a user portal. If this was a predatory, no-name entity, I would ignore it, but this was a serious request 000
Hunter Shain @shainlab.bsky.social · 22/07/2026Major preprint from our group is out. Feedback welcome! We built the largest molecular atlas of cutaneous squamous cell carcinoma (cSCC) to date – linking somatic mutations and gene expression patterns to metastatic outcome. A thread 🧵 www.medrxiv.org/content/10.6...medrxiv.orgComprehensive molecular characterization of cutaneous squamous cell carcinoma reveals determinants of metastatic progressionCutaneous squamous cell carcinoma (cSCC) is the second most common form of cancer worldwide. While most cSCCs are not life-threatening, 2-5% of patients develop metastases. To better understand what c... 131
Hunter Shain @shainlab.bsky.social · 10/07/2026Lebron should just lean into the hoopla and do "The Decision 2.0" 000
Hunter Shain @shainlab.bsky.social · 09/07/2026I asked my echo to play classic rock, and it started playing Creed. I feel old! 010
Hunter Shain @shainlab.bsky.social · 28/06/2026Richard Scolyer, Cancer Expert Who ‘Became His Own Subject,’ Dies at 59 www.nytimes.com/2026/06/26/s...nytimes.comRichard Scolyer, Cancer Expert Who ‘Became His Own Subject,’ Dies at 59 000
Hunter Shain @shainlab.bsky.social · 15/06/2026At my institution, if you are a day late taking an online training module, there is no courtesy warning -- just an email straight to your boss (for me, Dept. Chair). 010
Hunter Shain @shainlab.bsky.social · 08/06/2026I heard the sad news on LI that Richard Scolyer passed away. He was a wonderful melanoma researcher and pathologist. He was a co-author on my first big paper in the field, describing the genomic landscape of desmoplastic melanoma. He was so kind and collaborative www.linkedin.com/posts/melano...linkedin.comIt is with a heavy heart that we share the deeply sad news that our cherished colleague Prof Richard Scolyer AO passed away yesterday 7th June 2026. Richard was a renowned pathologist and a world… | ...It is with a heavy heart that we share the deeply sad news that our cherished colleague Prof Richard Scolyer AO passed away yesterday 7th June 2026. Richard was a renowned pathologist and a world aut... 110
Hunter Shain @shainlab.bsky.social · 05/06/2026Visiting the National Cancer Institute with my colleague, Iwei Yeh, to learn about the cool science being carried out by the #HTAN project. 020
Hunter Shain @shainlab.bsky.social · 19/05/2026Apparently, my institution has a committee on committees, and they are seeking members. While I have a soft spot for service, I might pass on this one 010
Reposted by Hunter ShainNature Cell Biology @natcellbio.nature.com · 18/05/2026☕ @shainlab.bsky.social , @bishaltandukar.bsky.social & co dissect the mutational, gene expression and morphological features of adult human skin melanocytes at single-cell resolution. bit.ly/4wzMyX0bit.lySomatic mutations distinguish melanocyte subpopulations in human skin - Nature Cell BiologyTandukar et al. dissect the mutational, gene expression and morphological features of adult human skin melanocytes at single-cell resolution. 0115
Hunter Shain @shainlab.bsky.social · 16/05/2026Celebrating 4 oral presentations from our team at the Society of Investigative Dermatology Meeting in Chicago! Loes Hollestein @sharmaharsh.bsky.social Bárbara Rentroia Pacheco and myself with support from Arne Van Hoeck and Domenico Bellomo of SkylineDx BV. Look out for new prognostic tests in cSCC 030
Hunter Shain @shainlab.bsky.social · 07/05/2026STmut can now operate on Atera data from 10X Genomics. Here is a breast cancer that was profiled on the Atera platform 121
Hunter Shain @shainlab.bsky.social · 06/05/2026www.latimes.com/science/stor...latimes.comRFK Jr. clears path for minors' use of tanning beds, much to the dismay of dermatologistsIndoor tanning is associated with a 75% increase in melanoma risk. A proposed FDA rule intended to protect children is now gone. 100
Reposted by Hunter ShainBishal Tandukar @bishaltandukar.bsky.social · 29/04/2026Excited to share our latest work from @shainlab.bsky.social lab, now out in Nature Cell Biology: “Somatic mutations distinguish melanocyte subpopulations in human skin.” We find evidence that melanocyte stem cell dynamics shape human skin homeostasis and UV response. www.nature.com/articles/s41...nature.com 042
Hunter Shain @shainlab.bsky.social · 27/04/2026Excited to share that our paper, “Somatic mutations distinguish melanocyte subpopulations in human skin,” is now out in Nature Cell Biology. Reposting the thread below ⬇️ 170
Reposted by Hunter ShainRita Strack @ritastrack.bsky.social · 22/04/2026For the fourth time in my ~12 year editorial career I was able to accept (in principle) a paper after one round of review. 🥳 4462
Hunter Shain @shainlab.bsky.social · 19/04/2026@marinelab.bsky.social rocks it in the opening plenary of #AACR26, describing how to harness cellular plasticity to combat minimal residual disease. And I love the shoutout to STmut! Congrats Chris on all your success. 1100
Hunter Shain @shainlab.bsky.social · 18/04/2026Why does Dillon Brooks have the Wikipedia logo tattooed on his arm 010
Hunter Shain @shainlab.bsky.social · 18/04/2026Kicking off the the #AACR26 strong with a great lineup of speakers. Myself, Irene Ghobrial, Li Ding, and Indu Kohaar (left to right). #HTAN 070
Reposted by Hunter ShainNuria Lopez-Bigas @nlbigas.bsky.social · 15/04/2026Tumor promotion through the lens of evolution This review grew out of many long conversations, shared ideas, and lively discussions It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk rdcu.be/fdC2Jrdcu.beTumour promotion through the lens of evolutionNature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable... 13314
Hunter Shain @shainlab.bsky.social · 16/04/2026When they are healthy, the Warriors are still a great team 000
Reposted by Hunter ShainInigo Martincorena @imartincorena.bsky.social · 15/04/2026Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbrrdcu.bePolyclonal selection of immune checkpoint mutations in thyroid autoimmunityNature - Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity 14720
Hunter Shain @shainlab.bsky.social · 15/04/2026I am looking forward to attending #AACR26. I will be chairing an educational session describing work done by the Human Tumor Atlas Network (HTAN) on Friday at 3pm. 171
Reposted by Hunter ShainThe Wall Street Journal @wsj.com · 15/04/2026Erica Schwartz is expected to be selected by the Trump administration to lead the Centers for Disease Control and Prevention, pending approval from President Trump.on.wsj.comTrump Administration Eyes Erica Schwartz to Lead CDCThe health agency is facing leadership turmoil and controversy over vaccine guidance. 865
Hunter Shain @shainlab.bsky.social · 03/04/2026On route to the Final Four. Easiest packing for a trip ever. Let’s go Illini! 010
Hunter Shain @shainlab.bsky.social · 01/04/2026www.thebulwark.com/p/rfk-jr-cre...thebulwark.comRFK Jr., Creature of the Tanning Salon, Throws the Industry a BoneThe HHS secretary has crispy, orange-toned skin in the game. 000
Hunter Shain @shainlab.bsky.social · 29/03/2026Here is my haul from the American Academy of Dermatology (AAD) meeting. One of the higher yield exhibition halls of any meeting that I attend. 020
Reposted by Hunter ShainIllini Hoops @illinihoops.bsky.social · 27/03/2026For the 2nd time in 3 years: Your Illinois Fighting Illini are going to the Elite 8!! I-L-L! 1527
Hunter Shain @shainlab.bsky.social · 26/03/2026Once you get over the learning curve, ScienCV is not terrible. However, it is extremely inconvenient if you want to collaborate with people who do not routinely submit NIH grants, such as clinicians or foreign researchers. 000
Hunter Shain @shainlab.bsky.social · 25/03/2026Dead Pubmed, if I am 7th till last author on a manuscript, then it probably should not be the top hit when searching by "best match" 010
Hunter Shain @shainlab.bsky.social · 25/03/2026Is it still ok to bold your name on the biosketch, making it easier for reviewers to see where you are on an author list? And can you add asterisks to denote co-authorships? Or are edits not allowed after printing from ScienCV? 100
Reposted by Hunter ShainHiten Madhani @hitenmadhani.bsky.social · 21/03/2026Very sad to hear of the passing today of our UCSF colleague Mike Bishop at the age of 90. A legendary and inspiring figure. He also led UCSF as Chancellor. Have a listen to his Nobel lecture. youtube.com/watch?v=CDv7...youtube.comMichael Bishop, Nobel Prize in Physiology or Medicine 1989: Official LectureYouTube video by Nobel Prize 59944
Hunter Shain @shainlab.bsky.social · 19/03/2026www.npr.org/2026/03/19/n...npr.orgFDA backs off stricter tanning bed rules with RFK Jr.'s supportHealth officials with the Trump administration have backed away from an effort to more heavily regulate indoor tanning — despite protests from medical groups that warn of the dangers of skin cancer. 010
Reposted by Hunter ShainAlex Rubinsteyn @alexr.bsky.social · 15/03/2026The good and bad thing about bsky is that there’s no dog mRNA mania on here 071
Hunter Shain @shainlab.bsky.social · 12/03/2026Got a grant review back and the main concerns from reviewer 1 were exactly the same as what Chat GPT said. Maybe AI is really that good, but I am worried the tail is wagging the dog with reviewers parroting AI and not the other way around. 100
Hunter Shain @shainlab.bsky.social · 19/02/2026Snow in the San Francisco Bay Area. Pictured here is Mount Diablo 020
Reposted by Hunter ShainDaniela Robles-Espinoza @daniela-oaks.bsky.social · 18/02/2026We are very happy to see our study finally appear online @nature.com! This has been work of nearly 10 years in collaboration with the National Institute of Genome Medicine 🇲🇽, the National Cancer Institute 🇲🇽, the @sangerinstitute.bsky.social and others ⬇️ www.nature.com/articles/s41...nature.comAncestry and somatic profile indicate acral melanoma origin and prognosis - NatureAnalysis of the somatic and transcriptomic profile of 123 acral melanoma samples from Mexican patients helps understand tumour origins and prognosis, and highlights the importance of including samples... 149141
Hunter Shain @shainlab.bsky.social · 14/02/2026Blue sky needs to improve its suggested accounts feature. Now that the starter packs have dried up, there is no easy way to find scientists with dozens to hundreds of followers. All my suggestions are for large media accounts. 000
Hunter Shain @shainlab.bsky.social · 14/02/2026I found the prime use for AI tools -- understanding tax law! 000
Hunter Shain @shainlab.bsky.social · 13/02/2026marginalrevolution.com/marginalrevo...marginalrevolution.comI Regret to Inform You that the FDA is FDAing Again - Marginal REVOLUTIONI had high hopes and low expectations that the FDA under the new administration would be less paternalistic and more open to medical freedom. Instead, what we are getting is paternalism with different... 000