Brain-wide transcriptomic profiling in mice reveals that reproductive experience remodels the maternal brain by altering dopamine dynamics in the dorsal hippocampal formation, causing dopamine-depende...

Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Therapeutics; Epigenetics; Neuroscience

An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.

Histone post-translational modifications (PTMs), particularly lysine acetylation (Kac), are critical epigenetic regulators of gene transcription underlying long-term memory consolidation. Beyond Kac, ...

The design of enzymes with complex active sites that mediate multistep reactions remains an outstanding challenge. With serine hydrolases as a model system, we combined the generative capabilities of ...

Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)–cl...

Abstract. Mislocalization of overexpressed CENP-A (Cse4 in budding yeast) contributes to chromosomal instability (CIN) in yeasts, flies, and human cells. O

The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

We are seeking to recruit a highly motivated scientist to establish and lead an independent research laboratory at the EMBL Epigenetics and Neurobiology Unit in Rome. EMBL provides a unique environmen...

“We’re talking about massive layoffs across the Triangle if this (rule) holds,” former UNC-Chapel Hill Chancellor Holden Thorp said.

In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.

Move to cut indirect cost rate to 15% could cost universities billions of dollars

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Legislative Mandates in Effect for FY 2024 NOT-OD-24-110. NIH

Intranuclear actin contributes to nuclear structure. Inducing actin remodeling within the nucleus regulates chromatin accessibility, and is associated with phenotypic outcomes in mesenchymal stem cell...

Exhausted T cells (TEX) in cancer and chronic viral infections undergo metabolic and epigenetic remodeling, impairing their protective capabilities. However, the impact of nutrient metabolism on epige...

Postdoctoral researchers sponsored by the National Institutes of Health now toil longer than ever before, for less money. They are responding accordingly.

imated $1.29 billion reduction in 2020 costs if they replaced the Medicare prices. Objectives We sought to investigate the savings for all drugs commonly used in urogynecology. Study Design We r...

Scientists engaged in work to make research fields more inclusive face canceled contracts and expired grants

ALT: a sign that says " what is even happening " next to a dumpster

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