Excited to share a new study 📑 led by myself and @benjaminweekley.bsky.social! We identify KMT2E, a novel reader of histone serotonylation. KMT2E loss causes the rare monogenic 🧬 ODLURO syndrome and disrupts chromatin dynamics during 🧠 development. Check out here! www.biorxiv.org/content/10.6...
biorxiv.org
KMT2E recruitment by H3 serotonylation regulates neurodevelopmental chromatin dynamics
Histone H3 Gln 5 serotonylation (H3Q5ser) is a recently identified epigenetic modification in brain that modulates reader interactions with adjacent H3 Lys 4 trimethylation (H3K4me3) to promote transc...
