Becki Lee @beckilee.bsky.social · 22/05/2026This was a small study and not powered to determine efficacy, but it provides a foundation for future ctDNA studies in melanoma and treatment sequencing approaches. Thanks to funders, participating sites, and especially the patients involved. 021
Becki Lee @beckilee.bsky.social · 22/05/20264/5 Key finding #3: longitudinal ctDNA monitoring provided early signals of both treatment response and resistance, often before radiological changes were seen. 📈 121
Becki Lee @beckilee.bsky.social · 22/05/20263/5 Key finding #2: ctDNA enabled personalised treatment. Patients started targeted therapy and switched to immunotherapy after an 80% reduction in BRAF VAF in ctDNA. All patients reached this threshold, typically within 2–3 weeks. 💊 101
Becki Lee @beckilee.bsky.social · 22/05/20262/5 Key finding #1: rapid, real-time ctDNA testing is feasible. Across multiple centres, ctDNA results could be processed and reported within 7 days, supporting treatment decisions in real clinical practice. 🧬 101
Becki Lee @beckilee.bsky.social · 22/05/2026Pleased to share results from the CAcTUS Phase II trial of ctDNA-guided therapy in BRAF-mutant advanced melanoma are now published! 🌵🧬 CAcTUS is the first melanoma trial to adapt treatment based on ctDNA testing. Read: www.nature.com/articles/s41...nature.comUse of circulating tumour DNA to prospectively guide a switch from targeted to immune therapy in BRAF mutant advanced melanoma: the randomised phase II CAcTUS trial - Nature CommunicationsTargeted therapy (with BRAK and MEK inhibitors) and immune checkpoint blockade have improved survival for patients with advanced BRAF-mutant cutaneous melanoma, however, the optimal scheduling for the... 2117
Reposted by Becki LeeBen Goldacre @bengoldacre.bsky.social · 23/02/2026OpenSAFELY is open from today! Huge thanks to all who supported this vast collaboration: whole population GP data; in a productive platform; innovative privacy protections; unprecedented support from professions, privacy campaigners; &c Now it's over to users! www.bennett.ox.ac.uk/blog/2026/02...bennett.ox.ac.ukOpenSAFELY news: you can apply to do non-COVID research, from today! | Bennett Institute for Applied Data ScienceWe are delighted to announce that - from today - you can submit applications to the OpenSAFELY service for non-COVID-19 studies. 618692
Reposted by Becki LeeMark O’Neill 🐻 @radiobeartime.com · 22/02/2026www.deadlanguagesociety.com/p/how-far-ba... I cannot speak as to the accuracy of the piece yet I found it a fascinating exercise @adamroberts.bsky.social @drlauravarnam.bsky.socialdeadlanguagesociety.comHow far back in time can you understand English?An experiment in language change 2212064
Reposted by Becki LeeJon Lim, FRCP PhD @drjonlim.bsky.social · 03/02/2026👉...cutting-edge science, clinical insights & discussions re: real-world implementation of TIL therapy. Featuring keynote speakers: Inge Marie Svane 🇩🇰 & Sebastian Klobuch 🇳🇱. @sklobuch.bsky.social @debrajosephs.bsky.social @turajliclab.bsky.social @beckilee.bsky.social 043
Becki Lee @beckilee.bsky.social · 22/01/2026Exciting conference alert! sites.manchester.ac.uk/from-lab-to-... Fantastic speakers including Chris Marine, Christian Blank Melanoma evolution Local microenvironment of melanoma Melanoma-host interactions Precision immunotherapy Emerging therapeutics Clinical trials and real-world data 075
Reposted by Becki LeeJon Lim, FRCP PhD @drjonlim.bsky.social · 01/12/2025🩺 Fantastic opportunity for #YoungOncologists: ICF-ESMO programme for an 8-week observership. We've excellent opportunities here in Manchester & would be happy to support (✉️: the-christie.observers@nhs.net). @christieinstitute.bsky.social @myesmo.bsky.social 📥 For more info (due 25 Jan 2026) 👇esmo.org 081
Becki Lee @beckilee.bsky.social · 30/11/2025Excited about not one but 2 fantastic conferences in Manchester! So timely as cell therapies are on the standard care horizon! 021
Reposted by Becki LeeJon Lim, FRCP PhD @drjonlim.bsky.social · 30/11/2025⏰ Calling all melanoma enthusiasts! The abstract submission deadline for the inaugural “Lab to Life: Innovations in Melanoma Research Conference UK 2026” has been extended to 19 December 2025! Happening 12-13 March 2026 at The Midland Hotel, Manchester. Submit your abstract and register here:sites.manchester.ac.ukHomeLab to Life: Innovations in Melanoma is a UK conference in Manchester on cutting-edge melanoma research, translational science and advances in treatments. 188
Becki Lee @beckilee.bsky.social · 22/11/2025Cancer detectives a hit in our house! Bench to bedside look at the DETECTION trial- Inspiring scientists of the future and an insight into why science is important, the breakthroughs they fund and what it means to the people involved www.channel4.com/programmes/c... 010
Becki Lee @beckilee.bsky.social · 16/10/2025Melanoma UK today visited the Smiths Melanoma hub today learning about the amazing work all of these lovely people are doing! Thanks for funding us! @mcrcnews.bsky.social 080
Reposted by Becki LeeSéamus O’Reilly MDPhD @seamusoreilly.bsky.social · 14/10/2025Attending #ESMO25 Join us to learn about sustainability integration into cancer care and the environmental impacts of AI 👇 @myesmo.bsky.social @robchuter.bsky.social @beckilee.bsky.social @pawelsobczuk.bsky.social @ouchinternational.bsky.social @irishdocsenv.bsky.social @cancertrialsie.bsky.social 1115
Becki Lee @beckilee.bsky.social · 07/10/2025Amazing work throughout the UK to smash our recruitment target! 020
Reposted by Becki LeeCarers In STEMM @carersinstemm.bsky.social · 26/09/2025We are pleased to announce the publication of our STEMM sector-wide survey The report highlights our findings & suggests recommendations. Now available to download here carersinstemm.co.uk Please share especially w/ institutions, funders & allies @laurawolz.bsky.social @carterlj.bsky.social 064
Reposted by Becki LeeMax Kozlov @maxkozlov.bsky.social · 25/09/2025NEW: Nature trained AI to predict which NIH grants from 2014 would have been cut if the Trump admin had its way back then — and what science would have been lost to history. "The results show the damage that cuts in funding can do to research, and the unpredictable nature of the research process." 212459
Reposted by Becki LeeAdrian Liston @labliston.bsky.social · 19/09/2025For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...currentprotocols.onlinelibrary.wiley.com 1015869
Becki Lee @beckilee.bsky.social · 11/09/2025Very pleased to say DETECTION2 has just randomised it's 50th patient! Awesome work by patient groups @melanomafocus.bsky.social , UK clinical teams @christieinstitute.bsky.social R+I and SCTU funded by @cancerresearchuk.orgmedia.tenor.comsnoopy is standing in front of a fireworks display and says `` congratulations ! ''Alt: snoopy is standing in front of a fireworks display and says `` congratulations ! '' 070
Reposted by Becki LeeBluesky @bsky.app · 08/09/2025v1.108 is rolling out today 🚚 Now live, at long last: Bookmarks, aka Saved Posts. For all those posts you'll definitely plan to come back to! Update the app and give it a try. The button is right down there 👇 1090236226049
Becki Lee @beckilee.bsky.social · 22/08/2025G3 www.jobs.manchester.ac.uk/Job/JobDetai... G5 www.jobs.manchester.ac.uk/Job/JobDetai...jobs.manchester.ac.ukResearch Technician:Oxford Road 000
Becki Lee @beckilee.bsky.social · 22/08/2025The Lee lab is expanding! We are really interested in mechanisms of local and systemic immune tolerance particularly in liver metastases - X2 research technicians 💡 Creative fun environment 🌱 Opportunities to grow 🫂 Highly collaborative with clinical+basic research 📢 Please spread word!jobs.manchester.ac.ukResearch Technician:Oxford Road 175
Reposted by Becki LeeMetastasis Research Society @metastasisresearch.bsky.social · 06/08/2025Calling all ECRs in cancer and metastasis research. Don't forget to register for the upcoming ECR Virtual Symposium in November (FREE for MRS members). More details here metastasis-research.org/2025/08/06/2... 162
Becki Lee @beckilee.bsky.social · 30/07/2025⭐We have a clinical fellow opportunity with the melanoma team! ⭐ Very friendly and supportive team Lots of learning opportunities including clinical trials and immune therapy Apply here👇 urldefense.com/v3/__https:/...urldefense.comJob vacancy: Clinical Research Fellow, The Christie NHS Foundation Trust, Manchester | trac.jobs 011
Becki Lee @beckilee.bsky.social · 24/07/2025🚨 Exciting new paper alert 🚨 From the Marie lab ⭐They have identified new melanoblast cell states which are reawakened in metastasizing and immunotherapy resistant melanoma ⭐ Can target using hdac inhibitors #melsm #melanoma #cancer www.biorxiv.org/content/10.1...biorxiv.orgTransitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasisMelanoma plasticity, driven by phenotype state switching, underlies clinically relevant traits such as metastasis and therapy resistance. As melanoma progression is thought to recapitulate aspects of ... 041
Reposted by Becki LeeJose M. Adrover @adrover.bsky.social · 17/07/2025I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) www.nature.com/articles/s41...nature.comNeutrophils drive vascular occlusion, tumour necrosis and metastasis - NatureNeutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis. 36325
Becki Lee @beckilee.bsky.social · 02/07/2025Mathematical models and ctdna have reached the clinic - the ultimate personalised trial testing adaptive targeted therapy highlighted in the news today! #EBEcancer25 www.express.co.uk/life-style/h...express.co.ukUK cancer breakthrough as simple blood test could help pinpoint treatmentEXCLUSIVE: Skin cancers can be among the most aggressive forms of the disease so using drugs to shrink them must be used with precision. 031
Becki Lee @beckilee.bsky.social · 02/07/2025Absolutely loving this course - fantastic discussions between all and the delegates and faculty. So many exciting Q's coming out of this! 050
Reposted by Becki Leeeriksahailab.bsky.social @eriksahailab.bsky.social · 17/06/2025Excited to share our new study on how resistance to AKT inhibition is linked to lineage differences within breast cancer 👇🏽 Stellar work @colindhratcliffe.bsky.social www.biorxiv.org/content/10.1... and also surprisingly/worryingly good AI generated podcast 🎧 notebooklm.google.com/notebook/28e... 072
Reposted by Becki LeeThe Francis Crick Institute @crick.ac.uk · 03/06/2025The deadline for early bird registration for the 5th Crick Cancer Conference has been extended. See the full programme and book by 15 July to take advantage of reduced ticket rates for early bookers ⤵️ www.crick.ac.uk/whats-on/5th...crick.ac.uk5th Crick International Cancer Conference 075
Becki Lee @beckilee.bsky.social · 03/06/2025Super proud of our fellow Tomasso Bosetti presenting his poster at #ASCO25 on the impact of timing of immune therapy and outcomes across cancers - the early 🐦catches the 🪱! 040
Becki Lee @beckilee.bsky.social · 03/06/2025Our data and the lung cancer trial also presented are very compelling for early time of day immune therapy treatment urldefense.com/v3/__https:/...urldefense.comProgram Guide – ASCO Meeting Program Guide 010
Reposted by Becki LeeTrevor Graham @trevorgraham.bsky.social · 22/05/2025Single cell whizz with green fingers for molecular genomics? Want to develop and apply new technologies for profiling #cancer #evolution? Like single cell WGS + ATAC: www.biorxiv.org/content/10.1... Perhaps our senior scientific officer role is for you? jobs.icr.ac.uk/vacancies/12... @icr.ac.ukjobs.icr.ac.ukHigher or Senior Scientific Officer in Sutton | The Institute of Cancer ResearchView details and apply for this Higher or Senior Scientific Officer vacancy in Sutton. Salary : Salary from 39,805 to 49,023 Reporting to: Prof Trevor Graham Duration of ... 154
Becki Lee @beckilee.bsky.social · 20/05/2025Happy international trials day! Bit more info on one of the trials we have developed from research done @cruk-mi.bsky.social and now bringing to patients thanks to CRUK and @southamptonctu.bsky.social 061
Reposted by Becki LeeRob Noble @robjohnnoble.bsky.social · 06/05/2025The Department of Integrated Mathematical Oncology @mathonco.bsky.social (Moffitt Cancer Center, Tampa, Florida) is also advertising an Open Rank Tenure-earning Faculty Position in Mathematical Oncology. For this and other openings see mathematical-oncology.org/jobsmathematical-oncology.orgJobsmathematical-oncology.org 046
Reposted by Becki LeeWaggoner Lab @labwaggoner.bsky.social · 05/05/2025Review @cp-immunity.bsky.social Role of specialized sensory neuron subtypes in modulating peripheral immune responses www.cell.com/immunity/ful... 0154
Becki Lee @beckilee.bsky.social · 05/05/2025Fantastic news for Europe - does anyone know what this means for the UK and whether we are part of it now we are back in Horizon? 000
Reposted by Becki LeeCancer Research UK Manchester Institute @cruk-mi.bsky.social · 02/05/2025We are recruiting - two exciting positions to check out this Bank Holiday weekend: 🥼 #Postdoctoral Scientist with @sylvaindelaunay.bsky.social 🥼 Amit Patel #Leukaemia Research Fellowship & Cancer Research UK Manchester Institute Senior Clinical Institute Fellow www.cruk.manchester.ac.uk/careers/ 011
Reposted by Becki LeeCold Spring Harbor Laboratory @cshlnews.bsky.social · 29/04/2025A new Science summary spotlights a paper by CSHL’s Tobias Janowitz and colleagues that uncovers a neural circuit linking inflammation to reduced motivation in a mouse model of cancer cachexia. Check out the Science summary here: www.science.org/doi/10.1126/... #Cachexia #ScienceMagazinescience.orgHow does cancer affect motivation?Inflammatory cytokines hijack a brain circuit to cause apathy in cancer 094
Reposted by Becki LeeWaggoner Lab @labwaggoner.bsky.social · 26/04/2025Review @annualreviews.bsky.social @lindavsinclair.bsky.social @cantrell-lab.bsky.social Protein Synthesis and Metabolism in T Cells www.annualreviews.org/content/jour... 0224
Becki Lee @beckilee.bsky.social · 24/04/202520th patient recruited to DETECTION2! 🎉 Amazing work across the UK to get this study done! 010
Becki Lee @beckilee.bsky.social · 23/04/2025Great paper from the Fairfax lab interrogating the effect of CMV status and immune therapy response www.nature.com/articles/s41...nature.comCMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade - Nature MedicineAnalysis of multiple cohorts of patients with melanoma demonstrates a positive association between cytomegalovirus serostatus and overall survival in patients treated with monotherapy but not combinat... 250
Reposted by Becki LeeWaggoner Lab @labwaggoner.bsky.social · 22/04/2025IL-10 targets IRF transcription factors to suppress IFN and inflammatory response genes by epigenetic mechanisms @natimmunol.bsky.social www.nature.com/articles/s41... 0122
Reposted by Becki LeeWaggoner Lab @labwaggoner.bsky.social · 14/04/2025Review @natbiotech.nature.com Engineering innate immune cells for cancer immunotherapy www.nature.com/articles/s41... 0183