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Andrew Pines

@andrewpines.bsky.social
466 followers 368 following 83 posts

Postdoctoral Research Fellow at Brigham and Women’s Hospital. Interested in psychosis, causality, neuroimaging, neuromodulation

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Reposted by Andrew Pines
Arielle Keller @ariellekeller.bsky.social · 01/05/2026
SO PROUD of my amazing students representing team ACORN Lab @acornlab.bsky.social at #SOBP2026! I am the luckiest mentor! 🥰 Way to go Natalie, @caitiebaten.bsky.social and @heatherarobinson.bsky.social! 🎉
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Michael Fox @foxmdphd.bsky.social · 17/04/2026
Thank you @avaskham.bsky.social @thetransmitter.bsky.social for covering the ongoing discussion re lesion network mapping. It is commendable when a news publication covers both sides of an issue, and a great example of unbiased and responsible reporting.
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Devika Narain @neuronarain.bsky.social · 14/04/2026
Our work on how neural circuits in the cerebellum encode prior probabilities led by Julius Koppen is out now in Nature Neuroscience www.nature.com/articles/s41... Big thanks to Julius Koppen & the whole team! And dedicated to all of us who found inspiration in Bayesian theories of the brain!
nature.com
Neural circuits encode prior knowledge of temporal statistics - Nature Neuroscience
This study shows that cerebellar circuits learn and encode prior probabilities of event timing. Cell-type-specific neural activity reflects environmental statistics and guides predictive motor behavio...
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Stimulating Brains @stimulatingbrains.org · 17/03/2026
Have you heard about the primacy of movement over sensation? Why is action the ultimate source of knowledge? Check it out in our brand new episode with none less than György Buzsáki here: stimulatingbrains.org/76-gyorgy-bu...
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Donna Dierker @donnadierker.bsky.social · 05/03/2026
Andreas Horn breaks down recent exchanges on the lesion network mapping method.
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Phil Corlett @philcorlett.bsky.social · 27/02/2026
This is a robust response. I particularly liked this figure - clarifying why the original critique showed what it did, and what was missing @foxmdphd.bsky.social
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Marvin Petersen @petersenm.bsky.social · 23/02/2026
We don't think it invalidates the approach. We looked into this in our data and replicated the key result showing convergence to non-specific connectome structure. However, our results also suggest there is a practical fix that is already implemented in some LNM studies. bsky.app/profile/pete...
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Marvin Petersen @petersenm.bsky.social · 23/02/2026
New preprint: Revisiting the methodological foundation of lesion network mapping. doi.org/10.64898/202... A thread.
doi.org
Revisiting the methodological foundation of lesion network mapping
Lesion network mapping (LNM) links focal brain lesions to distributed neural circuits by projecting lesion locations through a normative functional connectome. van den Heuvel and colleagues recently s...
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Michael Fox @foxmdphd.bsky.social · 26/02/2026
A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...
biorxiv.org
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Andreas Horn @andreashorn.org · 27/02/2026
A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method. See below 👇 for our response. www.biorxiv.org/content/10.6...
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Stimulating Brains @stimulatingbrains.org · 20/01/2026
🧠⚡ New year, fresh StimBrains talks! Join us when we explore the brain networks driving schizophrenia & how we can treat them via DBS. January session (Thurs, Jan 29, noon ET / 6pm CET) feat. the amazing @andrewpines.bsky.social & Nicola Cascella ✨ Get Zoom link here: talks.stimulatingbrains.org
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Andreas Horn @andreashorn.org · 19/12/2025
What is the status of DBS for epilepsy? Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/ A 🧵 — please RT for reach! 🙏
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Andrew Pines @andrewpines.bsky.social · 20/01/2026
Super excited about this!
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Science X / Phys.org @sciencex.bsky.social · 19/01/2026
Activating brain regions linked to reward and positive expectations may be associated with increased antibody responses following vaccination, suggesting a connection between mental states and immune function. doi.org/hbkjfq
medicalxpress.com
Can training your brain boost immune response? Vaccination study highlights power of positive thinking
Training people to activate a part of the brain linked to reward and positive expectations may be associated with an increase in the body's immune response to a vaccine.
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Michael Fox @foxmdphd.bsky.social · 18/01/2026
Are connectome-based network mapping methods and the >200 papers that have used it invalid? New paper out in @NatureNeuro says YES. nature.com/articles/s41... I have concerns about this new paper's methods and conclusions, but am biased. What do others think?
nature.com
Investigating the methodological foundation of lesion network mapping - Nature Neuroscience
The lesion network mapping method links diverse brain lesions to similar functional brain networks, reflecting general brain organization rather than disorder-specific circuits.
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Ben Hayden @benhayden.bsky.social · 23/12/2025
New Perspective from myself, Sarah Heilbronner and @myoo.bsky.social . “Rethinking the centrality of brain areas in understanding functional organization” in Nature Neuroscience. 🧵 rdcu.be/eVZ1A
rdcu.be
Rethinking the centrality of brain areas in understanding functional organization
Nature Neuroscience - Parcellation of the cortex into functionally modular brain areas is foundational to neuroscience. Here, Hayden, Heilbronner and Yoo question the central status of brain areas...
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Holmes Lab @holmeslab-bhi.bsky.social · 11/11/2025
The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more! Please rt and reach out if you’re interested 👀 Find out more holmeslab.rutgers.edu
Flyer to join Holmes Lab
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Andreas Horn @andreashorn.org · 22/08/2025
🚨 New preprint out! 🚨 “Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application” 🔗 doi.org/10.1101/2025...  🧵 A short thread:
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Thomas Yeo @bttyeo.bsky.social · 17/07/2025
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...
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Damien Fair @drdamienfair.bsky.social · 26/06/2025
Alert!!!! “An Action Networks Model for Pain” We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it. 👉 thread below 🧵 osf.io/preprints/ps...
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Alexander Li Cohen @drdrxanderli.bsky.social · 17/06/2025
Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover! 🔗 Full article: onlinelibrary.wiley.com/doi/full/10.... @childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social
onlinelibrary.wiley.com
Coordinate Network Mapping of Focal Brain Volume Differences in ADHD Reveals Common Patterns That Lack Specificity: A Systematic Review
Objective Attention-deficit/hyperactivity disorder (ADHD) has been associated with decreased regional brain volume, yet no consistent localization has emerged across studies. This discrepancy has be...
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Shan Siddiqi @shansiddiqi.bsky.social · 23/03/2025
Out now in Brain A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican. With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman academic.oup.com/brain/advanc... @braincircuits.bsky.social
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Awais Aftab @awaisaftab.bsky.social · 23/05/2025
Mixed Bag #22: Nils Wendel on Learning Psychopharmacology Wendel explores the topic using a book, a concept, a person, an article, and a surprise item www.psychiatrymargins.com/p/mixed-bag-...
psychiatrymargins.com
Mixed Bag #22: Nils Wendel on Learning Psychopharmacology
A book, a concept, a person, an article, and a surprise item
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Andreas Horn @andreashorn.org · 14/05/2025
MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects? @science.org @braincircuits.bsky.social @netstim.org – a thread🧵! www.science.org/doi/10.1126/...
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The Transmitter @thetransmitter.bsky.social · 16/05/2025
The brainstem’s red nucleus is an evolutionarily old structure that emerged as animals began to use limbs for walking, but its function in humans reaches beyond motor control, a new study suggests. By @sydneywyatt.bsky.social #neuroskyence www.thetransmitter.org/brain-imagin...
thetransmitter.org
‘Old’ brainstem structure evolved beyond basic motor control
The human red nucleus may also help coordinate action, reward and motivated behavior, a new study suggests.
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Andreas Horn @andreashorn.org · 12/05/2025
When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal: doi.org/10.1016/j.br...
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Sidhant Chopra @sidchop.bsky.social · 12/05/2025
🧠💊New preprint differentiating antipsychotic medication vs. illness effects on cortical thickness in people w/ psychosis. Finding: People receiving placebo show prominent cortical thinning over 1st year of illness, whereas those receiving antipsychotics do not. 1/3 www.medrxiv.org/content/10.1...
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Sheila Shanmugan @sheilashanmugan.bsky.social · 28/04/2025
We’re hiring a clinical research coordinator to lead a neuroimaging study on brain changes across pregnancy and perinatal depression. wd1.myworkdaysite.com/en-US/recrui... Please RT.
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Stimulating Brains @stimulatingbrains.org · 25/04/2025
It was a great honor to talk with the founding editor of Brain Stimulation, Dr. Harold Sackeim! Beyond the past, present and future of ECT, we covered the entire field of neuromodulation. Priceless insights from a key leader in the field! Tune in here 👇 stimulatingbrains.org/71-harold-sa...
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Stimulating Brains @stimulatingbrains.org · 22/04/2025
We had a truly inspiring and insightful conversation with Dr. Rees Cosgrove, Director of Epilepsy and Functional Neurosurgery at @brighamandwomens.bsky.social & Professor of Neurosurgery @harvardmed.bsky.social Rediscovering the lost art of brain lesions…! stimulatingbrains.org/70-rees-cosg...
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Sam Gershman @gershbrain.bsky.social · 16/04/2025
A postdoc in my lab contacted a fellow scientist to get some advice and was told that, because he's currently working on the topic, he "can't give away all his secrets." I find this extremely lame, and yet I keep encountering it. Science is not a zero-sum game!!
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Andreas Horn @andreashorn.org · 16/04/2025
Probably the most insightful and most important paper on physiomarkers of subthalamic DBS in a long while. Bravo @julianneumann.bsky.social @tsbinns.com and team!! Out at @natcomms.nature.com: www.nature.com/articles/s41...
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Precision Neurotherapeutics Lab @ Stanford @stanfordpntlab.bsky.social · 10/04/2025
When we use TMS to treat depression, we think it alters neural activity in a deep brain structure known as the subgenual anterior cingulate (sgACC). But this is hard to test directly, until our preprint with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes (UIowa) 1/
biorxiv.org
DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC
Transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) is hypothesized to relieve symptoms of depression by inhibiting activity in the subgenual anterior cingulate corte...
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Thomas Yeo @bttyeo.bsky.social · 26/03/2025
It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠
nature.com
A network correspondence toolbox for quantitative evaluation of novel neuroimaging results - Nature Communications
Here, the authors present the Network Correspondence Toolbox, which enables researchers to examine and report spatial correspondence between their neuroimaging results and widely used brain atlases.
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Isaiah Kletenik @isaiahneuro.bsky.social · 26/03/2025
Cool talk by Aaron Boes on clinical applications and cognitive prognosis from network neuroimaging @bostonchildrens.bsky.social @harvardmed.bsky.social
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Audrey Luo @audreycluo.bsky.social · 20/03/2025
We think of white matter as the brain's highways—uniform conduits between cortices. But what if we study development along tracts? Turns out the journey matters as much as the cortical destination! We're thrilled to share “Two Axes of White Matter Development” www.biorxiv.org/content/10.1... 1/n
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Can Sarica @cansarica.bsky.social · 22/03/2025
Proud to share the first of our two-part sequel papers on the #TUS-#DBS project! t.co/yrGRcdpjXn We recorded local field potentials using #PerceptPc #DBS systems in #Parkinsons patients while applying transcranial ultrasound stimulation (#TUS) — aiming to better understand its effects & mechanisms.
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Andreas Horn @andreashorn.org · 21/03/2025
Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder? Take a look at our summary of this exciting field and how things could be brought together out now in BPS: www.biologicalpsychiatryjournal.com/article/S000... A brief 🧵
biologicalpsychiatryjournal.com
Deep Brain Stimulation response circuits in Obsessive Compulsive Disorder
In the field of deep brain stimulation (DBS), two major themes are currently making significant progress. First, the framework of connectomic DBS, in which circuits that are associated with improvemen...
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Brigham and Women's Psychiatry Residents @bwhpsychresidency.bsky.social · 22/03/2025
We could not be more thrilled to welcome this amazing class to Brigham!
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Precision Neurotherapeutics Lab @ Stanford @stanfordpntlab.bsky.social · 18/02/2025
🧠 We are #hiring! Postdoc @stanfordmedicine.bsky.social: help us develop closed-loop EEG platforms to improve TMS treatment for depression! Coding and neuroscience / engineering backgrounds required. Join our team! precisionneuro.stanford.edu email: ckeller1@stanford.edu
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Andreas Horn @andreashorn.org · 07/03/2025
Goodbye study sections: www.nih.gov/news-events/...
nih.gov
NIH centralizes peer review to improve efficiency and strengthen integrity
The proposed approach is expected to save more than $65 million annually.
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Alexander Li Cohen @drdrxanderli.bsky.social · 04/03/2025
The Cohen Lab of Translational Neuroimaging is looking to hire a bioinformatics and research data scientist to help accelerate our research and develop new analysis tools! @bostonchildrens.bsky.social @braincircuits.bsky.social Please consider applying or sharing! jobs.brassring.com/TGnewUI/Sear...
jobs.brassring.com
Biomedical Informatics Research Data Scientist I- - Boston Childrens Hospital - Job Details
Job Details: Our mission is to identify the brain circuits responsible for symptoms common in autism and other neurodevelop
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CLaE @claeneuro.bsky.social · 26/02/2025
JAMA Psychiatry Mapping Lesions That Cause Psychosis to a Human Brain Circuit and Proposed Stimulation Target jamanetwork.com/journals/jam...
jamanetwork.com
Mapping Lesions That Cause Psychosis
This case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit
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Andrew Pines @andrewpines.bsky.social · 26/02/2025
Awesome work by @barbarahollunder.bsky.social showing how 4 different diseases that can all be modulated at a tiny nuclei (STN) can be differentiated by white matter tracts (to be a little hipster: I’ve been a fan of this since it was a preprint)
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Andrew Pines @andrewpines.bsky.social · 26/02/2025
Really thought-provoking talk by @julianneumann.bsky.social going over many things, including STN DBS but not Sinemet decreases cortical beta, and a super interesting theory about closed-loop timing of stimulation to beta phase
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Andrew Pines @andrewpines.bsky.social · 26/02/2025
Super cool talk by @karaannjohnson.bsky.social showing how evoked resonant neural activity (ERNA) can be used to guide DBS localization, direction, and (possibly even) more!
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Andreas Horn @andreashorn.org · 25/02/2025
Compelling talk by the one and only Shiro Horisawa on Forels field ablations in dystonia. Fantastic revival of a great historical target.
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Andreas Horn @andreashorn.org · 24/02/2025
Great talk as always by @karaannjohnson.bsky.social complementing insights about ERNA in GPi DBS and dystonia.
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Andrew Pines @andrewpines.bsky.social · 25/02/2025
Very interesting talk by Dr. Bohui Qian about common targets for movement and psychiatric disorders. They have implanted pts with coccurring disorders with great results. Dr.Qian is finishing her neurosurgery residency and planning on psych residency after! Super impressive-come to Boston!
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Can Sarica @cansarica.bsky.social · 25/02/2025
We’re thrilled to hear from Dr. Andreas Horn, this year’s Brain Stimulation Early Career Award winner, at #BrainStimConf today! Congratulations on this well-deserved recognition @andreashorn.org #BrainStim2025 @braistimjournal.bsky.social @braincircuits.bsky.social
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