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Holmes Lab

@holmeslab-bhi.bsky.social
176 followers 88 following 26 posts

The Holmes Lab works to understand the genetic and brain bases of individual differences in network organization across psychiatric illness. 📍Rutgers, Center for Advanced Human Brain Imaging Research holmeslab.rutgers.edu

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Reposted by Holmes Lab
Avram Holmes @avramholmes.bsky.social · 03/09/2026
New paper from former @holmeslab-bhi.bsky.social post-doc @sidchop.bsky.social. In first-episode psychosis, antipsychotic-naive patients on placebo showed widespread cortical thinning over 12mo. However, patients on antipsychotics did not. Thinning appears to be illness- not drug-driven.
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Loïc Labache @loiclabache.cpesr.fr · 02/07/2026
Happy to share that our work is finally published in @commsbio.nature.com! We identify molecular and cellular signatures of hemispheric specialization, linking language and attention to distinct neurotransmitter, mitochondrial, & cellular organization across the cortex 🧠 doi.org/10.1038/s420...
doi.org
Molecular and cellular correlates of human cortical lateralization - Communications Biology
Multimodal analyses reveal the molecular and cellular asymmetries underlying human cortical lateralization. Distinct neurotransmitter, mitochondrial, and cellular gradients support left-lateralized la...
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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · 21/07/2026
So excited to share that our study is out now in @natcomms.nature.com! 🧠🚨 www.nature.com/articles/s41... Big shout out to coauthors @sidchop.bsky.social @ashleasegal.bsky.social @loiclabache.bsky.social Rowena Chin Kaley Joss & @avramholmes.bsky.social
nature.com
Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease - Nature Communications
Cocuzza et al. show that brain network dynamics are less flexible in psychiatric illness, and these patterns predict individual symptom profiles better than diagnoses, highlighting brain dynamics as a...
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Ahmad Beyh @ahmadbeyh.bsky.social · 24/08/2026
⚠️ Preprint alert ⚠️ How does the brain's fixed anatomy support flexible function? We explore this using recurrent neural networks with increasing levels of brain-like constraints, comparing them to empirical fMRI activity. (1/8) www.biorxiv.org/content/10.6...
biorxiv.org
Geometric constraints and cognitive inputs jointly shape emergent brain dynamics and topology
How the brain's physical geometry gives rise to its flexible functional repertoire remains a central question in neuroscience. Here, we trained three classes of recurrent neural networks (RNNs) on a w...
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Avram Holmes @avramholmes.bsky.social · 11/11/2025
Looking for a post-bac RA position focused on the brain bases of affective and psychotic illness? @holmeslab-bhi.bsky.social is hiring! @cahbir.bsky.social @rutgersbhi.bsky.social @rutgersu.bsky.social @sobp-org.bsky.social @hitop-system.bsky.social @ohbmofficial.bsky.social
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Holmes Lab @holmeslab-bhi.bsky.social · 11/11/2025
The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more! Please rt and reach out if you’re interested 👀 Find out more holmeslab.rutgers.edu
Flyer to join Holmes Lab
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Holmes Lab @holmeslab-bhi.bsky.social · 07/10/2025
Holmes Lab + Parkes Lab had a great fall social a few weeks back!! Pottery painting (including an awesome brain-art mug by @ambrains.bsky.social 🧠). Thank you to our awesome mentors @avramholmes.bsky.social and @lindenmp.bsky.social for encouraging these great lab events! 💫
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Avram Holmes @avramholmes.bsky.social · 05/09/2025
The @cahbir.bsky.social and @rutgersbhi.bsky.social are hiring! Multiple open area and open rank faculty jobs, wonderful colleagues, amazing resources, and one of the largest communities of brain science research groups on the planet. Please apply and share widely. jobs.rutgers.edu/postings/209...
jobs.rutgers.edu
Human Neuroimaging Faculty Positions in Rutgers Brain Health Institute
The Center for Advanced Human Brain Imaging Research (CAHBIR), a component of the Rutgers Brain Health Institute (BHI) on the Busch campus in Piscataway, NJ, is recruiting for two open rank (Assistant...
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Avram Holmes @avramholmes.bsky.social · 04/09/2025
Latest @holmeslab-bhi.bsky.social preprint. Here, integrating genetic, post-mortem, and diffusion MRI data, Rowena Chin examines the heritability and cellular associates of late-life decline in white matter integrity. @cahbir.bsky.social @rutgersbhi.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
The cellular associates of late life changes in white matter microstructure
The microstructural architecture of white matter supporting information flow across local circuits and large-scale networks changes throughout the lifespan. However, the genetic and cellular factors u...
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Holmes Lab @holmeslab-bhi.bsky.social · 21/08/2025
Great write up of the @nature.com study on MRI economics by @bttyeo.bsky.social's research group! With @avramholmes.bsky.social @sidchop.bsky.social @carrisacocuzza.bsky.social
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Shaoshi Zhang @shaoshiz.bsky.social · 17/07/2025
🚨Thrilled to share our latest work just published in @nature.com where we looked into the optimal fMRI scan time for brain-wide association studies (BWAS) 🧠⏱️! Full thread below👇:
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Nico Dosenbach @ndosenbach.bsky.social · 17/07/2025
This new Yeo Lab tool should immediately and permanently replace sample-size-only power calculations for functional MRI. www.nature.com/articles/s41...
nature.com
Longer scans boost prediction and cut costs in brain-wide association studies - Nature
Although the number of participants is important for phenotypic prediction accuracy in brain-wide association studies using functional MRI, scanning for at least 30 min offers the greatest cost effect...
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Thomas Yeo @bttyeo.bsky.social · 17/07/2025
Everyone should try out the Trandiagnostic Connectome Project (TCP) dataset! Openly available on @openneuro.bsky.social
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Nature @nature.com · 17/07/2025
Nature research paper: Longer scans boost prediction and cut costs in brain-wide association studies go.nature.com/3IME4aA
go.nature.com
Longer scans boost prediction and cut costs in brain-wide association studies - Nature
Although the number of participants is important for phenotypic prediction accuracy in brain-wide association studies using functional MRI, scanning for at least 30 min offers the greatest cost effectiveness.
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Holmes Lab @holmeslab-bhi.bsky.social · 28/06/2025
Holmes Lab is representing at #OHBM2025! 🧵 Loic @loiclabache.bsky.social presented in the Language: Anatomy, Networks and Pathology section with his paper on "The molecular and cellular underpinnings of human brain lateralization" 🧠
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Sidhant Chopra @sidchop.bsky.social · 05/06/2025
Check out our latest open data release. n=240, most with a dsm-5 dx with extensive phenotying (~100 scales/subscale), rest and task functional imaging. See @carrisacocuzza.bsky.social's thread below for deets and links 👇🏾👇🏾👇🏾
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Cedric Boeckx @cedricboeckx.bsky.social · 07/06/2025
Very cool preprint examining how brain networks and cognition co-evolve during development By @bttyeo.bsky.social @lucinauddin.bsky.social @avramholmes.bsky.social @elvisha.bsky.social & colleagues 🧪🧠 www.biorxiv.org/content/10.1...
biorxiv.org
Convergent and divergent brain-cognition relationships during development revealed by cross-sectional and longitudinal analyses in the ABCD Study
How brain networks and cognition co-evolve during development remains poorly understood. Using longitudinal data collected at baseline and Year 2 from 2,949 individuals (ages 8.9-13.5) in the Adolesce...
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Reposted by Holmes Lab
Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · 04/06/2025
Check out my newest preprint to see the TCP dataset in action! 🤘🧠 Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease: www.biorxiv.org/content/10.1...
biorxiv.org
Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease
The network organization of the human brain dynamically reconfigures in response to changing environmental demands, an adaptive process that may be disrupted in a symptom-relevant manner across psychi...
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Holmes Lab @holmeslab-bhi.bsky.social · 10/06/2025
If you missed it, our open source 240-person transdiagnostic dataset is now published. Read the data release 👇👇 + find it on: OpenNeuro: openneuro.org/datasets/ds0... NDA: nda.nih.gov/study.html?i...
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Reposted by Holmes Lab
Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · 04/06/2025
🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉 www.nature.com/articles/s41... 🧵1👇
nature.com
The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry - Scientific Data
Scientific Data - The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry
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Avram Holmes @avramholmes.bsky.social · 04/06/2025
Our latest @holmeslab-bhi.bsky.social data release is now "live!" Available on NDA and @openneuro.bsky.social and spearheaded by @carrisacocuzza.bsky.social, @sidchop.bsky.social, and Connor Lawhead.
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 28/05/2025
Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease www.biorxiv.org/content/10.1101/202…
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Avram Holmes @avramholmes.bsky.social · 30/05/2025
New @holmeslab-bhi.bsky.social paper led by @carrisacocuzza.bsky.social. Brain dynamics across task and rest can be used to predict the presence of psychiatric illness (case/control status), diagnostic labels, and multi-dimensional symptom fingerprints. @rutgersbhi.bsky.social @rutgersu.bsky.social
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Holmes Lab @holmeslab-bhi.bsky.social · 02/06/2025
Check out Carrisa's new paper! An amazing investigation into brain network dynamics across psychiatric symptoms🔥🔥 + using our new open dataset the Transdiagnostic Connectome Project (TCP) 🔛 openneuro.org/datasets/ds0...
openneuro.org
OpenNeuro
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Holmes Lab @holmeslab-bhi.bsky.social · 29/05/2025
Great lab outing to Duke Farms yesterday! Happy spring from the Holmes + Parkes labs 😄 🌸 With @lindenmp.bsky.social @avramholmes.bsky.social @carrisacocuzza.bsky.social @ahmadbeyh.bsky.social @loiclabache.bsky.social (+ Amber Howell & Rachel Cooper)
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Avram Holmes @avramholmes.bsky.social · 20/05/2025
We're searching for a lead Research MRI technologists at @cahbir.bsky.social! Please share and pass along to any/all interested folks.
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Holmes Lab @holmeslab-bhi.bsky.social · 24/05/2025
Last month Linden Parkes and his team put out an amazing new work! They build on their network control theory model & improved whole-brain structure-function coupling Check this 🧵 for a summary 🔥 www.biorxiv.org/content/10.1...
biorxiv.org
Inferring macroscopic intrinsic neural timescales using optimal control theory
The temporal evolution of brain activity relies on complex interactions within and between brain regions that are mediated by neurobiology and connectivity. To understand these interactions, many larg...
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Reposted by Holmes Lab
Thomas Yeo @bttyeo.bsky.social · 11/04/2025
While the world burns, we cook up a new preprint! doi.org/10.1101/2025... Biophysical modeling is a key tool to derive mechanistic insights into the brain. These models are governed by biologically meaningful parameters (unlike artificial neural networks), but the dirty secret ... 1/N
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Holmes Lab @holmeslab-bhi.bsky.social · 15/04/2025
Newest #preprint from Holmes lab postdoc @loiclabache.bsky.social 🔥
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Avram Holmes @avramholmes.bsky.social · 12/04/2025
The molecular and cellular basis of human brain lateralization. Latest paper from @holmeslab-bhi.bsky.social led by @loiclabache.bsky.social. @rutgersbhi.bsky.social, @cahbir.bsky.social
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Holmes Lab @holmeslab-bhi.bsky.social · 08/04/2025
Check out the new article by our very own PI, Avram Holmes!
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Avram Holmes @avramholmes.bsky.social · 08/04/2025
"To make a meaningful contribution to #neuroscience, #fMRI must break out of its silo." My latest attempt to convince you of the importance of multi-scale approaches for the study of the human brain.
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Rutgers Brain Health Institute @rutgersbhi.bsky.social · 08/04/2025
🧠 Featured Insights! Dr. @avramholmes.bsky.social, Associate Prof of Psychiatry at RWJMS and Core Member of BHI & CAHBIR, shares insights on #fMRI and the need for integration across #neuroscience disciplines in @thetransmitter.bsky.social www.thetransmitter.org/future-of-fm... #neuroimaging
thetransmitter.org
fMRI must break out of its silo
We need to develop research programs that link phenomena across levels, from genes and molecules to cells, circuits, networks and behavior.
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Holmes Lab @holmeslab-bhi.bsky.social · 25/03/2025
PsyPost covered @lydiaquq.bsky.social's new paper linking internalizing/externalizing symptoms to distinct features! Check it out ⬇️ 🖇️https://www.psypost.org/scientists-identify-distinct-brain-patterns-linked-to-mental-health-symptoms #SciComm #Neuroscience
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Holmes Lab @holmeslab-bhi.bsky.social · 25/03/2025
Check out the latest Holmes Lab pre-print from @sidchop.bsky.social 🔥
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Prof Stephen Wood @stephenwood8.bsky.social · 24/03/2025
Great new work from @sidchop.bsky.social here at @orygen.org.au. @lenapl.bsky.social @matthewbroome.bsky.social @paoladzn.bsky.social
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Holmes Lab @holmeslab-bhi.bsky.social · 19/03/2025
We have stopped accepting applications for this role. Thank you to everyone who has applied!
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Holmes Lab @holmeslab-bhi.bsky.social · 13/03/2025
New in-depth feature about @OrchardWinnie's paper on health.com! Read it here: www.health.com/parents-youn... 🗣️Featuring comments from Dr @OrchardWinnie, Dr Avram Holmes, Dr Michelle Diblasi (Psychiatrist @TuftsMedicalCtr) and Dr Andrew Thaliath (@NortonNeuro)
health.com
Parenting Is Hard—But It Also Might Keep Your Brain Young
A new study found that parents' brains were protected against some of the impacts of aging, and this effect strengthened with each child. Experts explain why.
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Proceedings of the National Academy of Sciences @pnas.org · 11/03/2025
Raising children protects the brain against aging, according to an analysis of UK Biobank [link to accounts below] data. As benefits were observed in men and women, they are likely caused by the mental workout of caregiving, rather than pregnancy. In PNAS: www.pnas.org/doi/abs/10.1...
Portrait of parents and child preparing and eating breakfast in a home kitchen. Stock photo.
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Holmes Lab @holmeslab-bhi.bsky.social · 13/03/2025
Some Holmes Lab members at the Stand Up For Science 2025 in Philly! A great day with talks from superb scientists, council members and activists #standupforscience2025 #StandUpForScience
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Holmes Lab @holmeslab-bhi.bsky.social · 03/03/2025
The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more! Please rt and reach out if you're interested👀 Find out more holmeslab.rutgers.xn--edu-6p63b
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Holmes Lab @holmeslab-bhi.bsky.social · 03/03/2025
We are thrilled that Holmes lab recent paper by Xihan Zhang et al. has been featured on the cover of The Transmitter!@thetransmitter.bsky.social! Check out the paper here: tinyurl.com/cellnetworks And the article 🖇️ 🧬 www.thetransmitter.org/neuroanatomy...
thetransmitter.org
Cell ‘fingerprints’ identify distinct cortical networks
These networks align with different assemblages of cells, a finding that could reveal how cellular diversity influences brain function, according to a new study.
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Holmes Lab @holmeslab-bhi.bsky.social · 03/03/2025
The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more! Unfortunately, we cannot sponsor visas for this position. Please rt and reach out if you're interested👀
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The Transmitter @thetransmitter.bsky.social · 28/02/2025
The cerebral cortex is intricately organized, both at the level of cell types and macroscale functional networks. Those organizational layers are intertwined, as each network consists of a distinct blend of cell types, a new study finds. By Holly Barker www.thetransmitter.org/neuroanatomy...
thetransmitter.org
Cell ‘fingerprints’ identify distinct cortical networks
These networks align with different assemblages of cells, a finding that could reveal how cellular diversity influences brain function, according to a new study.
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Rutgers Brain Health Institute @rutgersbhi.bsky.social · 26/02/2025
🧠 Parenthood may have unexpected brain benefits! A new study led by Dr. Avram Holmes @avramholmes.bsky.social suggests that raising children could help protect against some effects of aging. 📖 Read more: www.pnas.org/doi/10.1073/... www.rutgers.edu/news/how-par...
rutgers.edu
How Parenthood May Help Keep Your Brain Young
Researchers from Rutgers and Yale find that parents show patterns of brain connectivity that oppose age-related changes.
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Sharna Jamadar @sharnajamadar.bsky.social · 26/02/2025
Congrats to Winnie Orchard & @sidchop.bsky.social on their new #ParentalBrain paper, now out in PNAS! They find evidence for the neuroprotective effect of parenthood for women AND men! 👩‍🍼👨‍🍼🧠 It's lovely work, and I'm proud to have played a tiny role in it. Read it here 👇 #neuroskyence #neuroimaging
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Holmes Lab @holmeslab-bhi.bsky.social · 27/02/2025
Some great coverage of @OrchardWinnie's new PNAS paper! A 🧵 (1/3) www.rutgers.edu/news/how-par... How does parenthood impact your brain? Check out Winnie's paper here: tinyurl.com/parentalbrain
rutgers.edu
How Parenthood May Help Keep Your Brain Young
Researchers from Rutgers and Yale find that parents show patterns of brain connectivity that oppose age-related changes.
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Holmes Lab @holmeslab-bhi.bsky.social · 25/02/2025
New paper‼️ Interested in the protective impacts of parenthood on brain dynamics? 👨‍👩‍👦‍👦🧠 Read Edwina Orchard & @sidchop.bsky.social's new paper, out now in PNAS @pnas.org ! With collaborators L. Ooi, P. Chen, L. An @bttyeo.bsky.social, and more! 🔗https://tinyurl.com/parentalbrain
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Avram Holmes @avramholmes.bsky.social · 19/02/2025
New @holmeslab-bhi.bsky.social paper by Lydia Qu. Here, we map shared and unique brain features for individual variation in internalizing and externalizing across development. w/@bttyeo.bsky.social, @elvisha.bsky.social, @carrisacocuzza.bsky.social, and many others. www.nature.com/articles/s44...
nature.com
Distinct brain network features predict internalizing and externalizing traits in children, adolescents and adults - Nature Mental Health
In this study, the authors present work showing shared and distinct predictive network features associated with internalizing and externalizing behaviors in children, adolescents and adults.
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Nature Neuroscience @natneuro.nature.com · 14/01/2025
A Perspective on considering the interconnected nature of social identities in neuroimaging research 🧪🧠 @elvisha.bsky.social www.nature.com/articles/s41...
nature.com
Considering the interconnected nature of social identities in neuroimaging research - Nature Neuroscience
Individual variability in behavior is influenced by social identities. Here, Dhamala et al. discuss the need to incorporate social identities in neuroimaging studies of behavior and explore how to fos...
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