This randomized clinical trial estimates the effect size of connectivity- vs scalp-based targeting of accelerated transcranial magnetic stimulation for treatment-resistant depression.

YouTube video by Night Science Institute

Tumour network mapping of diffuse midline glioma (DMG) defines a conserved and prognostically important brain network in children with DMG, consistent with the hypothesis that DMGs exploit otherw...

IntroductionAge-related declines in cognitive and motor functions show highly variable trajectories. To better understand the underlying mechanisms, we inves...

Neuronal ceroid lipofuscinosis type 2 (CLN2) disease, a lysosomal storage disorder, causes early childhood psychomotor regression, vision loss, seizures, and rapid progressive gray matter loss. Howev...

These findings from a large cohort advance the understanding of the oral microbiome–brain axis, highlighting specific microbial profiles linked to subclinical cognitive, structural, and inflammatory b...

After a January paper questioned the validity of an approach called lesion network mapping, its users are pressure testing their results.

Despite rapid exploitation of the opportunities that contextualization of brain maps affords, potential limitations have received little attention. In this Roadmap, Royer et al. provide practical guid...

Van den Heuvel et al. show that lesion-network mapping (LNM)-derived circuits converge across disorders and argue that this convergence reflects a fundamental methodological limitation of LNM. We eval...

Implements spatial null models and coordinate-space transformations for statistical comparison of brain maps, following the framework described in Markello et al. (2022)…

Lesion network mapping (LNM) links focal brain lesions to distributed neural circuits by projecting lesion locations through a normative functional connectome. van den Heuvel and colleagues recently s...

The landmark ongoing HEALthy Brain and Cognitive Development (HBCD) study will longitudinally chart brain development in a large sample (projected n=7,200) of infants through age 10 years with multimo...

Background and ObjectivesCerebral small vessel disease (CSVD) is associated with an increased risk of cognitive impairment and dementia. While its impact on white matter is well documented, CSVD-relat...

A field guide and why we need to rethink our expectations

The academic community has looked at how artificial-intelligence tools help researchers to write papers, but not how they distort the literature scientists choose to cite.

Generate design matrices, contrasts, and scripts to set up FSL randomise analyses. - jmumford/randomise-prep

BACKGROUND: White matter hyperintensities (WMHs) of presumed vascular origin are common in the elderly and are associated with vascular risk factors. There is evidence that vascular risk factors, in p...

How the human brain supports diverse behaviours has been debated for decades. The canonical view divides visual processing into distinct "what" and "where/how" streams – however, their origin and inde...

Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...