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Andrew Mendiola

@andrewmendiola.bsky.social
1.6K followers 403 following 104 posts

Assistant Professor, UCSD School of Medicine We study brain Immunology and how innate immunity drives inflammation in multiple sclerosis and Alzheimer’s. Mendiolalab.com

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Reposted by Andrew Mendiola
John Lukens @lukensjohnr.bsky.social · 13/01/2026
3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis cell.com/cell/fulltex... cell.com/cell/fulltex... www.cell.com/cell/fulltex...
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Andrew Mendiola @andrewmendiola.bsky.social · 09/01/2026
Endless
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Leon Smyth @leonsmyth.bsky.social · 07/01/2026
WE ARE HIRING! The Smyth Lab at Monash University is looking for a postdoc to join our team! Come join us if you are excited about neuroimmunology and the meninges. 📍 Melbourne, Australia 🇦🇺 Apply now: careers.pageuppeople.com/513/cw/en/jo... #Neuroimmunology #Meninges #PostdocJobs
careers.pageuppeople.com
Job Search
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Andrew Mendiola @andrewmendiola.bsky.social · 27/12/2025
Agency declines to reappoint Walter Koroshetz, who has led NINDS since 2015
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Marson Lab @marsonlab.bsky.social · 10/12/2025
Our latest collaboration with @jkpritch.bsky.social – led by joint post-doc Mineto Ota – is in @nature.com today: www.nature.com/articles/s41...
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Andrew Mendiola @andrewmendiola.bsky.social · 04/12/2025
Looking forward to reading this one!
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Staci Bilbo @sbilbo.bsky.social · 15/11/2025
I am very grateful for Steve's leadership and excited to step into this new role! www.neuro.duke.edu/news/lisberg...
neuro.duke.edu
Lisberger to step down as department chair; Bilbo named interim leader
Stephen Lisberger, PhD, George Barth Geller Distinguished Professor for Research in Neurobiology, will step down from his role as
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Sofiya Hupalo @sofiyahupalo.bsky.social · 14/11/2025
NIH grant applicants: October and November grant application submission *deadlines* will be rescheduled (🤯). Specific dates TBD. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-005: Interim Guidance on Reopening of NIH Extramural Activities
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Interim Guidance on Reopening of NIH Extramural Activities NOT-OD-26-005. NIH
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Jeremy Berg @jeremymberg.bsky.social · 08/11/2025
Bluetorial-Jim Watson I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions. What follows is my personal perspective. 1/41
media.tenor.com
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
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Mari Sosa @marisosa.bsky.social · 06/11/2025
Applications are open for the 2026 Zara Weinberg cohort of Leading Edge, named in honor of the incredible, brilliant, fearless @weinberz.witchlab.org. The LE community has been truly transformative for my scientific journey and my happiness. Please apply!! www.leadingedgesymposium.org/apply/
leadingedgesymposium.org
Apply | leadingedgesymposium
Apply. The 2026 Leading Edge cohort application is now open! This cohort is named the Zara Weinberg Cohort, in honor of 2021 Leading Edge Fellow, Zara Weinberg. Applications are due February 2, 2026.
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Willow Coyote-Maestas @willowcoyote.bsky.social · 31/10/2025
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed. She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
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Andrew Mendiola @andrewmendiola.bsky.social · 30/10/2025
Excited to share some research highlights today during the neuroimmune sessions at KAI2025, beautiful day in Incheon, Korea
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Joe Sabatino @jsabatino37.bsky.social · 16/09/2025
Very pleased to publish this new review with Farah Wahbeh on the role of #EBV in #Multiplesclerosis. I learned a lot writing this, I hope others find it useful too www.neurology.org/doi/10.1212/...
neurology.org
Epstein-Barr Virus in Multiple Sclerosis | Neurology Neuroimmunology & Neuroinflammation
Epstein-Barr virus (EBV) is a very common herpesvirus that infects more than 90% of the general population. Epidemiologic data indicate that EBV is a requisite risk factor for the development of multi...
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Jeremy Berg @jeremymberg.bsky.social · 02/09/2025
A show of bipartisan support for NIH. Basically flat except for ARPA-H. The President’s budget proposal basically ignored (as it should have been).
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Andrew Mendiola @andrewmendiola.bsky.social · 21/08/2025
Honored to receive an @alzassociation.bsky.social Research Grant for my project “Role of APOE4-driven microglial mitochondrial dysfunction”. Excited to advance our research on APOE4, neurovascular inflammation, and microglial metabolism in Alzheimer’s disease. Grateful to be #ALZFunded !!
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Ivan Zanoni @lozanzi.bsky.social · 21/08/2025
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
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Dan Tyrrell @danis1337.bsky.social · 21/08/2025
This is so frustrating. In 2018 I remember thinking how this paper would transform my work since we were already looking at mitophagy. I have cited this paper in 3 of my papers between 2018-2020 and probably every grant application. This guy won a 2021 breakthrough prize in part because of this work
RETRACTED ARTICLE: Parkin and PINK1 mitigate STING-induced inflammation
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Anders Sejr Hansen @andersshansen.bsky.social · 20/08/2025
I have NIGMS R35, impact score 12 NIHGRI R21, 4th percentile NHGRI R01, 7th percentile (co-I) and it seems like none will be funded. 0/3. PO (who has been very helpful) said "Unfortunately, I do not expect this application will be selected for funding in FY25." 😭
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Andrew Mendiola @andrewmendiola.bsky.social · 20/08/2025
one of the best!
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Elaine Hsiao @pipethero.bsky.social · 20/08/2025
Delighted to share this perspective piece by Lewis Yu on microbial regulation of serotonin and neuroimmune interactions. Looking forward to sharing more on this topic soon 🤞 www.sciencedirect.com/science/arti...
sciencedirect.com
Microbial regulation of serotonin and neuroimmune interactions
Bidirectional communication between the gut microbiota and neuroimmune system is essential during host–microbiome interactions. Recent research has be…
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Andrew Mendiola @andrewmendiola.bsky.social · 14/08/2025
Managed to track down some texas-style bbq in san diego. Gathered the lab to celebrate their accomplishments and keep building our amazing community!
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Johanna Joyce @johannajoyce.bsky.social · 13/08/2025
The numbers of women in science falls substantially at the transition from postdoc to independent investigator/ PI So what can we do to prevent this? One initiative we now organise annually at #EACR is the highly successful 'Women in Leadership' workshop ⏬ #WomenInScience 🧪 @helloeacr.bsky.social
magazine.eacr.org
The EACR’s Women in Leadership workshop returns for 2025 - The Cancer Researcher
Ahead of the EACR 2025 Congress in Lisbon, Portugal, the EACR once again hosted its popular Women in Leadership Workshop on 16 June 2025. The event brought together 26 early-career female cancer resea...
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Ran Blekhman @blekhman.bsky.social · 09/08/2025
200 days in, checking in on HHMI funding opportunities: Freeman Hrabowski Scholars Program - not accepting applications Gilliam Fellows Program - not accepting applications Hanna H. Gray Fellows Program - not accepting applications Investigator Program - not accepting applications
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Kristian G. Andersen @kgandersen.bsky.social · 07/08/2025
Just to give the TL;DR on this one: *The* main purpose of the EO is to move funding priorities and decisions away from experts and career professionals over to political appointees. With the ultimate power held by Vought / OMB.
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Andrew Mendiola @andrewmendiola.bsky.social · 07/08/2025
Thrilled to share that I received the NoA for my first R01 “Mechanisms of pathogenic microglial populations in CNS inflammation”. Major milestone for the Lab. Extremely grateful for SS/SRO, PO and everyone else at NINDS for their continued support. Photo of my lab, wife and son, celebrating!
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Ryan Flynn @raflynn5.bsky.social · 06/08/2025
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
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Andrew Mendiola @andrewmendiola.bsky.social · 06/08/2025
www.nature.com/articles/s41...
nature.com
EBV induces CNS homing of B cells attracting inflammatory T cells - Nature
Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.
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Maureen Barr @barrlab.bsky.social · 01/08/2025
We need a new microscope objective. A $1.6k tariff for something that you can hold in your hand and that is only manufactured in Germany
Quote for a 63x objective. The objective is $12,784. The tariff is $1,661.92Zeiss 63x objective
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Andrew Mendiola @andrewmendiola.bsky.social · 01/08/2025
www.sciencedirect.com/science/arti... Great review on "Alzheimer’s disease and vascular biology – A focus on the procoagulant state"
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Andrew Mendiola @andrewmendiola.bsky.social · 01/08/2025
Surreal…
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Shannon Macauley @macauleylab.bsky.social · 31/07/2025
🔥New preprint from the lab! Led by @rileyirmen.bsky.social Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance 📍 biorxiv.org/content/10.1101/2025.07.25.666872v1 🧵 on how tau disrupts the metabolism–excitability balance in Alzheimer’s disease
biorxiv.org
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance
Alzheimer's disease (AD) is not only characterized by amyloid-beta (Aβ) and tau pathology, but also by early and progressive disruptions in metabolism. Neuronal excitability is tightly coupled with me...
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Jeremy Berg @jeremymberg.bsky.social · 31/07/2025
Happening Now! Mark-up of Labor, Health, and Human Services www.appropriations.senate.gov/hearings/ful...
appropriations.senate.gov
Full Committee Markup of Defense and Labor, Health and Human Services, and Education Appropriations Acts | United States Senate Committee on Appropriations
United States Senate Committee on Appropriations
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Max Kozlov @maxkozlov.bsky.social · 31/07/2025
The NIH budget will INCREASE by $400 million — not slashed by 40%, as Trump proposed — according to a proposal by Senate appropriators, says Sen Murray. "Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.
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Andrew Mendiola @andrewmendiola.bsky.social · 30/07/2025
I hope this true!
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Liz Essley Whyte @lizessleywhyte.bsky.social · 30/07/2025
UPDATE: The pause was scrapped Tuesday evening after intervention by top White House officials. www.wsj.com/politics/pol...
wsj.com
Trump Administration Scraps Effort to Pause Health-Research Funding
The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.
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CNN @cnn.com · 29/07/2025
Dr. Uri Manor feels like much of his early life was blessed by fate.
cnn.com
A researcher with hearing loss got a grant to study restoring hearing. The Trump administration cancelled it because of DEI | CNN
Dr. Uri Manor feels like much of his early life was blessed by fate.
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BWJones @bwjones.bsky.social · 28/07/2025
The NIH was healthiest when pay lines were in the 20th percentile range. We are headed into an environment where pay lines are in the 5% range. In my entire career, I’ve only had 3 grants that scored better than 5%. And my lab is considered a successful one. This is going to destroy science.
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Andrew Mendiola @andrewmendiola.bsky.social · 29/07/2025
@manorlaboratory.bsky.social !
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Jason Moore @moorejh.bsky.social · 25/07/2025
Academic chairs waiting for endowments #academia
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Roel Verhaak @roelverhaak.bsky.social · 23/07/2025
PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.
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Jeremy Berg @jeremymberg.bsky.social · 21/07/2025
so.... NIH issued a news item clarifying the new use of animals policy. It seems that the bottom line is that NIH will not issue NoFOs specifically about creation or use of animal models of disease. 1/2 grants.nih.gov/news-events/...
grants.nih.gov
How Does the NIH Initiative to Prioritize Human-Based Research Affect Research Proposing the Use of Laboratory Animals? | Grants & Funding
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Dr. Michael D. L. Johnson @copperbae.bsky.social · 18/07/2025
NIH will only accept six new, renewal, resubmission, or revision applications from an individual Principal Investigator/Program Director or Multiple Principal Investigator for all council rounds in a calendar year. grants.nih.gov/grants/guide....
grants.nih.gov
NOT-OD-25-132: Supporting Fairness and Originality in NIH Research Applications
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supporting Fairness and Originality in NIH Research Applications NOT-OD-25-132. NIH
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Andrew Mendiola @andrewmendiola.bsky.social · 17/07/2025
Excellent paper -- adding to journal club lineup!
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Jeremy Berg @jeremymberg.bsky.social · 15/07/2025
Update on funding curves and late non-competitive renewals. First, funding curves for new and competitive renewals. 1/n
Graph showing NIH funding for new and competitive renewal grants for fiscal year 2025 compared to fiscal year 2024. The fiscal year 2025 curve is substantially below the fiscal year 2024 curve.
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Christian Frezza @frezzalab.bsky.social · 10/07/2025
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science www.science.org/doi/10.1126/...
science.org
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox
Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmito...
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Ruth Franklin @ruthfranklinlab.bsky.social · 11/07/2025
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
science.org
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
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Congressman Bill Foster @repbillfoster.bsky.social · 28/06/2025
The Trump Admin slashed over 1000 fellowships from the NSF's Graduate Research Fellowship Program, which has produced Nobel Prize winners, tech entrepreneurs, & national security experts. While countries like China are doubling down on scientific investment, Trump is hurting our pipeline of talent.
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Jeremy Berg @jeremymberg.bsky.social · 25/06/2025
New York Times article on the end (at least for the moment) of NIH grant terminations... [Gift link] www.nytimes.com/2025/06/25/s...
nytimes.com
N.I.H. Memo Pauses Cancellations of Medical Research Grants
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Stefanie Robel @stefanierobel.bsky.social · 18/06/2025
As per the NIH POs in our session just now: Columbia University is having funding freeze lifted. Nice to hear some good news for a change!
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Max Kozlov @maxkozlov.bsky.social · 16/06/2025
An NIH staffer reacts to today's ruling: "I'm looking forward to the day that we are so slammed with work trying to reinstate everything that we had to terminate illegally — I'll work 24/7 to make that happen if I can."
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