Here, using a mouse model of tauopathy, the authors reveal that disruption of the gut microbiome drives tau pathology and cognitive decline, and identify five microbial metabolites that directly promo...

Agirman et al. find that imidazole propionate, a microbiome-derived metabolite, reaches the brain, dampens hypothalamic activity, and promotes stress-related behaviors. Human data show that higher ImP...

Nature Communications - Gut bacteria digest dietary fiber and release molecules as energy for the host. Here, Yu et al. find that the ability of certain gut bacteria to digest different fibers...

Bidirectional communication between the gut microbiota and neuroimmune system is essential during host–microbiome interactions. Recent research has be…

Yu and Chandra et al. engineered a commensal gut microbe, Bacteroides thetaiotaomicron, to detoxify methylmercury (MeHg). The engineered bacterium reduces MeHg in the intestinal lumen, limits its accu...

Neuroscience; Microbiome

Here, the authors show that different formulations of medical ketogenic diets, and dietary fiber content in particular, differentially impact seizure outcome in mice, via modifying the gut microbiome ...