Reposted by Riley Irmen, M.S.
🔥New preprint from the lab! Led by @rileyirmen.bsky.social
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance
📍 biorxiv.org/content/10.1101/2025.07.25.666872v1
🧵 on how tau disrupts the metabolism–excitability balance in Alzheimer’s disease
biorxiv.org
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance
Alzheimer's disease (AD) is not only characterized by amyloid-beta (Aβ) and tau pathology, but also by early and progressive disruptions in metabolism. Neuronal excitability is tightly coupled with me...
