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Sofiya Hupalo

@sofiyahupalo.bsky.social
656 followers 390 following 112 posts

Neuroscientist interested in supporting mental health research & early career scientists. Posts ≠ endorsement.

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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 18/09/2026
Clinical trials in psychiatry rely on measures of symptomatology, not biology. This @acnporg.bsky.social position paper lays out why validated biomarkers in psychiatry have lagged behind fields like Alzheimer's and ALS, and what it will take to close the gap. www.nature.com/articles/s44...
nature.com
Toward actionable biomarkers in psychiatry: a collaborative roadmap for precision clinical trials. An ACNP position paper - NPP—Digital Psychiatry and Neuroscience
Psychiatric drug development remains constrained by diagnostic heterogeneity, insufficient and inconsistent drug response, high placebo response rates, and the absence of validated biomarkers that can...
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Reposted by Sofiya Hupalo
Neuropsychopharmacology @npp-journal.bsky.social · 25/08/2026
#TWiNPP Here, findings suggesting that thalamo-prefrontal circuit dysfunction is a potential mechanism linking SETD1A-associated genetic risk to working memory impairments in schizophrenia / @sofiyahupalo.bsky.social www.nature.com/articles/s41...
nature.com
Altered thalamo–prefrontal synchrony dynamics during spatial working memory task performance in a SETD1A loss-of-function mouse model of schizophrenia predisposition - Neuropsychopharmacology
Neuropsychopharmacology - Altered thalamo–prefrontal synchrony dynamics during spatial working memory task performance in a SETD1A loss-of-function mouse model of schizophrenia predisposition
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NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 20/08/2026
How do we move AI from raw model performance to effective and impactful mental health care? Building on insights from a pivotal @acnporg.bsky.social study group, the authors set 5️⃣ priorities to embed AI into clinical workflows with safety and equity at the core. 🧠💻 www.nature.com/articles/s44...
nature.com
Responsible and innovative AI for mental health care: five priority themes - NPP—Digital Psychiatry and Neuroscience
This paper synthesizes insights from a 2026 American College of Neuropsychopharmacology (ACNP) study group examining how to responsibly translate AI into clinical mental health care. Building on this ...
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 18/05/2026
*Last chance* to apply for our New Investigator Award 👇 www.nature.com/dpn/announce...
nature.com
Announcements | NPP—Digital Psychiatry and Neuroscience
Announcements
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Reposted by Sofiya Hupalo
Dr. Becca @docbecca.bsky.social · 19/04/2026
Those of us doing research related to women’s health have been hit particularly hard by the govt’s sabotage of the NIH. I spoke to WaPo for this piece, as painful as it was to discuss the reality my lab is facing. www.washingtonpost.com/science/2026...
washingtonpost.com
Where U.S. science has been hit hardest after Trump’s first year
The Trump administration has slashed the number of grants from the National Institutes of Health, with far fewer focused on women, cancer and mental health.
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 17/04/2026
One month left to apply 👇👇👇 Wondering if you're eligible or have other questions? DM us or email dpnjournal@acnp.org
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Sofiya Hupalo @sofiyahupalo.bsky.social · 13/04/2026
Just wow 🤩
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 09/04/2026
Interested in writing a Primer that bridges psychiatry and neuroscience? 💫 Email us your idea at dpnjournal@acnp.org 💫
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NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 01/04/2026
Can LLMs help the mental healthcare system keep up with growing demand? This Deep Dive explores whether a RoBERTa LLM can detect anxiety or depression in text, showing accuracy similar to human experts & paving the way for more accessible mental health evaluation. youtu.be/TJ4IKAIU0Ss?...
youtu.be
Can large language models help the mental healthcare system keep up with growing demand?
YouTube video by NPP - Digital Psychiatry and Neuroscience (DPN)
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 19/03/2026
📢 We’re excited to announce the next call for applications for the DPN Editors' New Investigator Award! This award waives the article processing charge ($2290) for new investigators who aim to publish an original report in DPN. Apply by May 18th! Details: www.nature.com/dpn/announce...
abstract image of brain made up of colorful interconnected blocks
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Sofiya Hupalo @sofiyahupalo.bsky.social · 19/03/2026
If you’re a new PI in the field of digital psychiatry/computational neuro and are preparing a manuscript, consider applying for this award 👇🏻
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Reposted by Sofiya Hupalo
Drug Monkey @drugmonkey.bsky.social · 17/03/2026
NOFO are dead...and that is not the actual problem drugmonkey.wordpress.com/2026/03/16/n...
drugmonkey.wordpress.com
NOFO are dead…and that is not the actual problem
A substack blog entry from NIH Program Officer Elizabeth Ginexi outlines the sharp discontinuation in the issuance of Notices of Funding Opportunity (NOFO) at the NIH in 2025 and 2026. These NOFO (…
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Reposted by Sofiya Hupalo
Mark Histed @markhisted.org · 16/03/2026
The next few yrs are likely to be EXTREMELY bad for science funding. Given what we've seen from this admin. Expect the grant system to work differently for years into future, unless stopped: Much lower success rates, $ sent to Trump allies and away from univs and blue areas
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Sofiya Hupalo @sofiyahupalo.bsky.social · 16/03/2026
💯 Unlike a year ago, we now know the strategies this administration is using to defund/disrupt US biomedical research. Sadly, other current events mean this issue is not getting enough media attention.
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 19/02/2026
🌟Announcing the next cohort of the DPN Editor’s New Investigator Waiver Award recipients🌟 Dr. Nicole Zürcher, @nicolerzurcher.bsky.social Dr. Jennifer Goldschmied, @jengoldschmiedphd.bsky.social Dr. Sarah Sperry, @drsarahsperry.bsky.social Congratulations! We're proud to support your work👏
Abstract image of building blocks making up a brain
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 11/02/2026
Our new Deep Dive covers a study by @carterfunkhouser.bsky.social, @dpagliaccio.bsky.social & colleagues, which linked EEG-based brain connectivity patterns with emotional expression from text messages to identify neural markers of depressive symptoms in teens youtu.be/a_yXb3wERfo
youtu.be
Tracking teen depression risk through brain connectivity and text message data
YouTube video by NPP - Digital Psychiatry and Neuroscience (DPN)
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DrGlitterbear @drglitterbear.bsky.social · 05/02/2026
Happy to see this conversation happening. As someone who withdrew from their 1st attempt at PhD due to mental health, way back in the mid-90's, it was very difficult to overcome that obstacle when applying to PhD programs again. I was always seen as a risk...even after completing a masters degree.
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Sofiya Hupalo @sofiyahupalo.bsky.social · 05/02/2026
Diversity supplements weren’t just for folks from underrepresented racial/ethnic backgrounds. Eligibility extended to first gen college students and researchers with disabilities, among others Cancelling these supplements limits opportunities for the next generation of scientists, as explained here
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 04/02/2026
Recapping the #ACNP2026 study group, “Centering Lived Experience in Psychiatric Neuroscience Research” We asked the panelists, what could NIH leadership do to be more supportive of trainees with non-traditional career paths, which is common among researchers with lived experience of mental illness?
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Max Kozlov @maxkozlov.bsky.social · 03/02/2026
I'm on Capitol Hill watching NIH director Jayanta Bhattacharya testify to the Senate HELP committee. Thankfully I haven't been escorted out of this event (yet). Here's what I'm following. You can also watch live here: www.help.senate.gov/hearings/mod...
help.senate.gov
Modernizing the National Institutes of Health: Faster Discoveries, More Cures | The U.S. Senate Committee on Health, Education, Labor & Pensions
Full Committee Hearing on February 3, 2026 at 5:00 AM
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Sofiya Hupalo @sofiyahupalo.bsky.social · 03/02/2026
Excited to share this preprint of my postdoc work, only several years late to the party 🎉 We examined how loss of function in SETD1A, a high confidence schizophrenia risk gene, impacts neural synchrony across circuits supporting working memory in mice. www.biorxiv.org/content/10.6...
biorxiv.org
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Michael Totty @mictott.bsky.social · 02/02/2026
New paper out on cortistatin neurons and their role in regulating fear and cortical hyperexcitability in the prelimbic cortex! This one has been a fun ride 🧵 www.biorxiv.org/content/10.6...
biorxiv.org
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The Transmitter @thetransmitter.bsky.social · 02/02/2026
Should neuroscience focus on big team science or the traditional model? Explore what survey respondents had to say about it: www.thetransmitter.org/funding/shou... #neuroskyence #StateOfNeuroscience
thetransmitter.org
Survey: Should neuroscience focus on big team science?
Learn which types of projects are better for big team science versus smaller-group support.
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 02/02/2026
🆕in DPN: Bargagna et al used a probabilistic deep learning model to automate MRI segmentation of the choroid plexus, demonstrating accurate results in an autism cohort and quantifying model confidence across multiple datasets. www.nature.com/articles/s44...
nature.com
A probabilistic deep learning approach for choroid plexus segmentation in autism spectrum disorder - NPP—Digital Psychiatry and Neuroscience
The choroid plexus plays an important role in brain health and immunity and may be altered in autism spectrum disorder (ASD). To analyze large imaging datasets, a method to automatically delineate thi...
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 27/01/2026
Our latest Deep Dive covers a study that developed a deep learning model to classify sleep stages from single channel EEG recordings in rats🐀. It predicted key parameters of sleep architecture, reducing the need for labor-intensive manual annotation. youtu.be/kEgCbyqC0jU?... @dranap.bsky.social
youtu.be
New deep learning tool allows automated analysis of sleep patterns using EEG data
YouTube video by NPP - Digital Psychiatry and Neuroscience (DPN)
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Reposted by Sofiya Hupalo
Britton Barbee @brittonrae.bsky.social · 18/01/2026
still talking about this study group - one for the books 📚 🫶🏻
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Haley Vecchiarelli @haleyv.bsky.social · 16/01/2026
I couldn't pick just one, but I had such a great time at #ACNP2026! Thank you so much for the past travel award support!! Always amazing to see the reviewers for @npp-journal.bsky.social and @dpn-journal.bsky.social each year (and to be a top reviewer again this year).
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Dr. Millie Rincón-Cortés @madrelabutd.bsky.social · 15/01/2026
Thrilled to share that I was promoted to Full Member! 🎉 🙌Grateful for the incredible mentorship, support, and community that made this milestone possible. Thanks to everyone who believed in me, including Tony Grace + @jaredwyoung.bsky.social for their letters, and to @acnporg.bsky.social 🙏 #ACNP2026
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Keri Martinowich @martinowk.bsky.social · 16/01/2026
I should have taken a selfie after #SachinSays poured a drink all over me last night in classic fashion. But, alas, I did not, so here is a #ACNP2026 Atlantis hippocampus. Thanks to everyone for a great meeting - so many friends to catch up with, exciting science convos & a little too much fun 😴
Seahorse on a wall of a building in front of the beach
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NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 16/01/2026
Thank you all for an unforgettable #ACNP2026 full of cutting-edge science, insightful discussions, and positive energy! See you next year in San Diego for #ACNP2027!
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Reposted by Sofiya Hupalo
ACNP @acnporg.bsky.social · 16/01/2026
📸 One last favor: Share your favorite photo from the meeting and tag us! We’d love to see #ACNP2026 through your eyes. Until next year... stay inspired!
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Sofiya Hupalo @sofiyahupalo.bsky.social · 16/01/2026
I had a fabulous time learning about new science and spending quality time with my favorite people at #ACNP2026. Until next time! @acnporg.bsky.social @madrelabutd.bsky.social @brainbodylab.bsky.social
Picture of conference attendees at ACNP 2026 annual meeting Picture of conference attendees at ACNP 2026 annual meeting Picture of conference attendees at ACNP 2026 annual meeting Picture of conference attendees at ACNP 2026 annual meeting
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Sofiya Hupalo @sofiyahupalo.bsky.social · 15/01/2026
Last day of #ACNP2026! Head over to Poseidon III-IV this morning from 9-11 to hear about how cross-species functional brain biomarkers are being used to improve translation and facilitate drug development in psychiatry 🧠
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Sofiya Hupalo @sofiyahupalo.bsky.social · 13/01/2026
What a powerful conversation about what it’s like to navigate life and a research career with lived experience of mental illness. I’m deeply grateful for the speakers being willing to share their experiences and how we can all be more supportive of our colleagues #ACNP206 @acnporg.bsky.social
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Dr. Connor Haggarty @connorhaggarty.bsky.social · 12/01/2026
Love some swag #ACNP2026
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NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 13/01/2026
Day 2 of #ACNP2026 trivia starts now!
Screenshot of trivia question at ACNP annual meeting
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Susanne Ahmari @ahmarilab.bsky.social · 13/01/2026
Ok seriously, if you’re not at the Lived Experience study group, you need to be. What an amazing panel-these researchers with lived experience have incredible insights to share about the benefits of integrating lived experience into research. Maya Schumer:it’s additive, not adversarial #ACNP2026
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Rachel Ross, MD, PhD @rossenator.bsky.social · 13/01/2026
Outstanding #acnp2026 day 2 start with @nicolagrissom.bsky.social reminding us of the principle that sex differences in neural mechanisms may drive behavior similarity. Leaning into the ambiguity of hidden markov models and showing that females exploit more; males explore more in a set shift task
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NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 13/01/2026
We’re excited for today’s Distinguished Lecture at #ACNP2026 @acnporg.bsky.social featuring DPN Senior Editors, Brenda Curtis and Sam Golden! 1 PM today in Grand Ballroom D-G!
Promotional slide highlighting distinguished lecture at ACNP annual meeting
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NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 12/01/2026
Got any questions about publishing in @dpn-journal.bsky.social & @npp-journal.bsky.social? Come meet the NPP and DPN Editors tomorrow at 2:30 in the Rotunda Foyer. We want to chat with you! #ACNP2026
Poster board featuring senior editors at DPN
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Dr. Lana Ruvolo Grasser @scientificruvvy.bsky.social · 12/01/2026
Update: I have acquired the highly sought-after hat and it matches my outfit! Meant to be. Thanks @dpn-journal.bsky.social @sofiyahupalo.bsky.social; it’s a great way to commemorate my positive experience writing a DNP Perspectives piece 😉✨#ACNP2026
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NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 12/01/2026
Curious about the latest advancements in the use of AI in mental health? Check out this #ACNP2026 Study Group today at 3 PM in Imperial Ballroom B with @mpwpaulus.bsky.social @crodriguezmdphd.bsky.social @royperlis.bsky.social @ksarma.com @pshrink.bsky.social @skhalsa.bsky.social, & John Torous.
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Sofiya Hupalo @sofiyahupalo.bsky.social · 12/01/2026
Sporting our DPN Deep Dive hats IRL! Stop by the @dpn-journal.bsky.social & @npp-journal.bsky.social desks to get some #ACNP2026 swag! @brittonrae.bsky.social @acnporg.bsky.social
ACNP 2026 attendees wearing DPN Deep Dive hats
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NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 12/01/2026
Trivia is back for #ACNP2026! Trivia questions will be emailed to meeting attendees twice/day on Monday-Wednesday. The top trivia winners will receive prizes 🏆💵! 🚨 Don’t snooze the first question at 7:45 am on Monday 🚨
media.tenor.com
a man in a suit and tie says okay , here 's your question .
Alt: Alex Trebek saying “okay , here's your question.”
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Reposted by Sofiya Hupalo
Susanne Ahmari @ahmarilab.bsky.social · 12/01/2026
Good morning #ACNP2026! 🌅 Cant wait to meet this years @acnporg.bsky.social travel awardees at the travel award breakfast 🤩
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NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 10/01/2026
Hello #ACNP2026 attendees👋 Our Editorial Intern @brittonrae.bsky.social will present a poster highlighting DPN's social media initiatives and special projects. Stop by her poster in the advocacy affiliate section on Tues-Thurs to chat with Britton. First few visitors will get SWAG 😮😆!
Promo for DPN poster at ACNP 2026 Annual Meeting, "From Launch to Legacy: Celebrating the Growth of NPP-Digital Psychiatry and Neuroscience (DPN)" by Britton Barbee.
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NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 10/01/2026
From freezing rain in the morning to sunny tropics this afternoon, we’re excited to be in Paradise Island for #ACNP2026!
Freezing rain at ORDParadise Island in the Bahamas
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Sofiya Hupalo @sofiyahupalo.bsky.social · 10/01/2026
1. Visit @brittonrae.bsky.social's poster at #ACNP2026 2. Learn about @dpn-journal.bsky.social 3. Get very special swag
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Sofiya Hupalo @sofiyahupalo.bsky.social · 09/01/2026
I'm excited to share that this week I transitioned to a new role at the Usona Institute, where I'll be supporting their clinical trial program evaluating psilocybin for treatment of MDD. Looking forward to this next chapter and being back in Madison, Wisconsin!
Photo of a happy couple in front of the Wisconsin capital.
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Keri Martinowich @martinowk.bsky.social · 09/01/2026
Honored to be appointed Chief Scientific Officer @lieberinstitute.bsky.social. LIBD is a uniquely collaborative place with extraordinary biological resources and a commitment to translation 🧠🔬🧪. Grateful to my colleagues and excited to help guide our next chapter! www.libd.org/keri-martino...
libd.org
Keri Martinowich, Ph.D., Chief Scientific Officer | The Lieber Institute for Brain Development | Research & Discovery
Lieber Institute for Brain Development Appoints Keri Martinowich, Ph.D., as Chief Scientific Officer Baltimore, MD (January 6, 2025) — The Lieber Institute for Brain Development (LIBD) announced the a...
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