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Abdel Mazouzi

@amazouzi.bsky.social
618 followers 448 following 21 posts

Scientist at the Netherlands Cancer Institute, EMBO fellow, Opinions are my own

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Reposted by Abdel Mazouzi
Mike Galsworthy @mikegalsworthy.bsky.social · 21/10/2025
FINALLY the BBC starts covering what we’ve all already seen. “A 55-year-old Palestinian woman has been taken to hospital after being clubbed over the head by a masked Jewish settler as she was picking olives.”
bbc.co.uk
Palestinian woman in hospital after being clubbed by masked Israeli settler
The attacker is seen striking the 55-year-old woman with a large wooden stick during the assault in the West Bank village of Turmus Ayaa.
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Ewan Birney @ewanbirney.bsky.social · 10/10/2025
I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
embl.wd103.myworkdayjobs.com
Staff Scientist
About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...
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Max-Planck-Gesellschaft @maxplanck.de · 17/09/2025
Open Call for Expressions of Interest: become a Max Planck Director & redefine what’s possible in science! We offer scientific independence, long-term stable funding & exceptional infrastructure. Lead your own department & open new frontiers of research. Apply by 31 Oct 2025 → www.mpg.de/directors
mpg.de
Directors
The Max Planck Society offers Directors a unique platform for groundbreaking research and leadership in diverse scientific fields.
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Sarah Moser @sarahmoser.bsky.social · 15/09/2025
Thank you @aacrjournals.bsky.social for highlighting our recent study on PARP inhibitors and histone turnover! 🧬💊
aacrjournals.org
Histone Recycling Promotes PARP Inhibitor Resistance
Major Finding: PARP inhibition induces eviction of histones, and the chaperone NASP is required to recycle these histones to prevent DNA damage and promote resistance. Concept: Histone recycling repre...
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IMP @impvienna.bsky.social · 10/09/2025
Sarah Moser ( @sarahmoser.bsky.social) from the lab of Jos Jonkers, Netherlands Cancer Institute (@nkinl.bsky.social) & Oncode Institute (@oncodeinstitute.bsky.social). 👏🏾 5/
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IMP @impvienna.bsky.social · 10/09/2025
Exciting news! We're thrilled to announce the six outstanding laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2025! 🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
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Abdel Mazouzi @amazouzi.bsky.social · 04/09/2025
Congrats Andre!
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The Groth lab @grothlab.bsky.social · 28/08/2025
We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute! Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
Image of Niels Mejlgaar (CEO of DNRF), Anja Groth (EpiC director) & Jesper Fisker (CEO of DCS).
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Netherlands Cancer Institute @nkinl.bsky.social · 22/08/2025
Breaking the chain: uncovering a hidden weakness in PARP-resistant cancers ➡️ www.nki.nl/news-events/... #fundamentalresearch #cancerresearch #NKI #breastcancer #ovariancancer
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Nature @nature.com · 18/08/2025
Nature research paper: NASP modulates histone turnover to drive PARP inhibitor resistance go.nature.com/45vRWhd
go.nature.com
NASP modulates histone turnover to drive PARP inhibitor resistance - Nature
PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.
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Francesca Mattiroli @fmattiroli.bsky.social · 16/08/2025
Happy to see this impressive work from Sarah, Abdel, Jos, and colleagues out! Congratulations!! and happy we could contribute a tiny bit. Changes in histone dynamics is a mechanism of drug (PARPi) resistance in tumors, and it may be exploited in therapy.
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Sarah Moser @sarahmoser.bsky.social · 13/08/2025
This project has been a truly exciting chapter of my PhD journey and I am deeply grateful to everyone involved. A heartfelt thank you to my mentors, @josjonkers.bsky.social and @amazouzi.bsky.social for their guidance in solving the histone puzzle.
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Sarah Moser @sarahmoser.bsky.social · 13/08/2025
Thrilled to share our latest work, just published in @nature.com ⬇ www.nature.com/articles/s41... We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors. 🧵 (1/8)
nature.com
NASP modulates histone turnover to drive PARP inhibitor resistance - Nature
PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.
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Craig Kaplan @triggerloop.bsky.social · 13/08/2025
Extremely cool!
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Abdel Mazouzi @amazouzi.bsky.social · 14/08/2025
Thank you for sharing!
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Barbara Marte @barbmarte.bsky.social · 14/08/2025
new out in Nature yesterday www.nature.com/articles/s41...
nature.com
NASP modulates histone turnover to drive PARP inhibitor resistance - Nature
PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.
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Abdel Mazouzi @amazouzi.bsky.social · 13/08/2025
Here is the link to get the PDF of our paper in case you don’t have access to Nature: rdcu.be/eAChv
rdcu.be
NASP modulates histone turnover to drive PARP inhibitor resistance
Nature - PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.
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Abdel Mazouzi @amazouzi.bsky.social · 13/08/2025
Thanks Sabrina!
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Abdel Mazouzi @amazouzi.bsky.social · 13/08/2025
Thanks Andre!
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Abdel Mazouzi @amazouzi.bsky.social · 13/08/2025
I am thrilled to share with you my first co-corresponding author Nature paper with Jos Jonkers. This project was led by the extraordinary @sarahmoser.bsky.social . Congratulations, and thank you to all the authors, @nkinl.bsky.social , and @oncodeinstitute.bsky.social for their support.
nature.com
NASP modulates histone turnover to drive PARP inhibitor resistance - Nature
PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.
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Di Jiang @dijiang319.bsky.social · 08/07/2025
@science.org Zincore-coregulator dedicated to zinc🖐️ TFs essential in development www.science.org/doi/10.1126/... @rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.
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Danielle Bianchi @daaninthelab.bsky.social · 04/07/2025
In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11
science.org
Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression
Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...
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Netherlands Cancer Institute @nkinl.bsky.social · 27/06/2025
Proud! 💙 Our scientific director Thijn Brummelkamp receives the Spinoza Prize, a prize for scientists who belong to the best researchers worldwide. A wonderful recognition for his groundbreaking research. Congrats Thijn! 🎉 @thijnbrummel.bsky.social Full article ➡️ bit.ly/40p4KnK
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puckknipscheer.bsky.social @puckknipscheer.bsky.social · 13/06/2025
Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)
science.org
RNA transcripts regulate G-quadruplex landscapes through G-loop formation
G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...
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Ryohei Thomas Nakano (Hokudai) @luckystrike1984.bsky.social · 06/06/2025
Hey my fellow Germans! I wasn't aware, but there is an AvH-JSPP postdoc fellowship, dedicated to German citizens aiming to do their postdoc in Japan. It covers salary + travel to Japan + startup for your life in Japan. Let me know if you are interested! www.humboldt-foundation.de/en/apply/spo...
humboldt-foundation.de
JSPS Research Fellowship
The Japan Society for the Promotion of Science (JSPS) Research Fellowship supports you as a highly qualified postdoc from Germany in conducting your research in Japan – regardless of discipline.
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Abdel Mazouzi @amazouzi.bsky.social · 02/06/2025
Great news from The ERC : erc.europa.eu/news-events/...:
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Abdel Mazouzi @amazouzi.bsky.social · 21/03/2025
Really cool story highlighting one of the most beautiful genetic suppression interactions between SRBD1 and condensin II! #CoolScience www.linkedin.com/feed/update/...
linkedin.com
SRBD1, a highly conserved gene required for chromosome individualization | Jonne Raaijmakers
Excited to share our latest publication in Cell Reports! Our study reveals the critical role of SRBD1, a highly conserved and previously enigmatic essential…
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Anoek Friskes @anoekfriskes.bsky.social · 06/03/2025
Some DNA damage, RAD51, MND1, cohesin and RAD54L with a lot of imaging! www.biorxiv.org/content/10.1...
biorxiv.org
Visualizing homology search in living cells
Homologous recombination (HR) is a DNA repair process that requires a homologous sequence for the repair of DNA double-stranded breaks. The search for homology is the rate limiting step for HR, but th...
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Abdel Mazouzi @amazouzi.bsky.social · 03/03/2025
Extensive review of 30 years of BRCA1 biology by @sarahmoser.bsky.social and @josjonkers.bsky.social! Such a fascinating protein, and this is probably just the tip of the iceberg of what BRCA1 can do. I am sure more surprises are coming in the next three decades!
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Kurianlab @kurianlab.bsky.social · 24/02/2025
*Tenured full Professorship in Genetics and Molecular Cell Biology* at the University Of Cologne, Germany It's an opportunity to rebuild the place that used to be home to luminaries including Benno Müller-Hill, Max Delbruck, Campos-Ortega, Diethard Tautz Maria Leptin, Thomas Langer
academicpositions.com
Professorship in genetics and molecular cell biology (W3) (f/m/d) - Academic Positions
The University of Cologne is one of the oldest and largest universities in Germany. With its six Faculties covering a broad spectrum of disciplines and its i...
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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 12/01/2025
Identification of critical factors of the replication stress response in human cells www.biorxiv.org/content/10.1101/202…
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Sarah Moser @sarahmoser.bsky.social · 09/01/2025
Happy to have contributed to this issue 🎉 @akhalizieva.bsky.social did an amazing job exploring our current knowledge on our two favourite genes, BRCA1 and BRCA2, and how this is being used to target BRCA1/2-mutated tumors. Check it out ⬇️ genesdev.cshlp.org/content/39/1...
genesdev.cshlp.org
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
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Niels Keijzer @nkeijzer.bsky.social · 17/12/2024
Excited to share our new paper! Here we reveal USP1/UAF1 as a highly efficient DUB for K63- and K48 polyubiquitinated PCNA and give detailed insights into its mechanism that may drive pathway choice in DNA damage tolerance. Preprint is available now: www.biorxiv.org/content/10.1...
biorxiv.org
USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that enriches for monoubiquitinated PCNA
DNA damage tolerance (DDT) is an important pathway that allows our cells to bypass DNA lesions during replication. DDT is orchestrated by ubiquitination of PCNA: Monoubiquitination (PCNA-Ub) initiates...
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Titia Sixma @titiasixma.bsky.social · 17/12/2024
Despite the black picture below, we're really happy to have this illuminating story online! Careful molecular mechanistic from Niels and others in the lab work giving unexpected biological insight!
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Abdel Mazouzi @amazouzi.bsky.social · 09/12/2024
Very cool, Simon!
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Abdel Mazouzi @amazouzi.bsky.social · 09/12/2024
Blown away by David Baker's Nobel Prize lecture in chemistry. Just wow! www.youtube.com/live/HnT1VWz...
youtube.com
YouTube
Share your videos with friends, family, and the world
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Abdel Mazouzi @amazouzi.bsky.social · 07/12/2024
I find this a quite useful summary from Nature’s Hiring in Science Survey 2024.
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Abdel Mazouzi @amazouzi.bsky.social · 07/12/2024
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Abdel Mazouzi @amazouzi.bsky.social · 07/12/2024
Based on Nature’s Hiring in Science Survey 2024, the majority of hirers are not using AI as part of the application process. Those in academia are particularly unlikely to embrace it in the future. I find it difficult to believe—do you? figshare.com/s/7aea1f12aa...
figshare.com
Nature’s Hiring in Science survey 2024
Springer Nature conducted a global survey of hiring managers in science in 2024, in partnership with Thinks Insights & Strategy, a research consultancy based in London. The survey launched in June 202...
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Orlando D. Schärer @orlandoscharer.bsky.social · 04/12/2024
What are your plans for October 2025? It would be a fantastic time to visit Norway for the Endogenous DNA Damage and Repair conference with a stellar set of speaker covering a wide range of topics. www.endodnadamage.com
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Coleman Lindsley @coleman-lindsley.bsky.social · 03/12/2024
We just opened a search for a lab-based faculty position at Dana-Farber @danafarber.bsky.social @harvardmed.bsky.social Any area of cancer research is fair game and MD, PhD, or MD/PhD are encouraged to apply. Please spread the word: www.nejmcareercenter.org/job/829239/l...
nejmcareercenter.org
Laboratory-based Investigator, Faculty Search - Boston, Massachusetts job with Dana-Farber Cancer Institute | 829239
Laboratory-based Investigator, Faculty Search The Department of Medical Oncology at the Dana-Farber Cancer Institute (DFCI) and the Brigham and Wom...
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Abdel Mazouzi @amazouzi.bsky.social · 02/12/2024
Many people in hiring positions take their roles for granted and don’t bother to help or even send proper emails to the applicants. You are truly an inspiration!
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Abdel Mazouzi @amazouzi.bsky.social · 02/12/2024
Thank you, Ben! I really admire your spirit of sharing and your efforts to help the next generation of leaders. I hope you inspire more people and institutions to do the same.
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Ben Garcia @garcialabms.bsky.social · 02/12/2024
An update on our Dept faculty search. We had 165 applications and after reviewing, we discussed the top 30. 12 were selected for Zoom interviews, and then we discussed and selected 5 for in person interviews which start soon. For those still interviewing, Zoom questions are attached. Good luck!
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Dan Brierley @drdanbrierley.bsky.social · 28/11/2024
Looking for a host institution for your group leader level fellowship application(s)? Apply to our department! www.ucl.ac.uk/work-at-ucl/... This is how I started my lab here, so very happy to chat with anyone interested in this route - drop me a message! 🧪🧠 #neuroskyence
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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Liam Faller @liamfaller.bsky.social · 27/11/2024
"Negative reinforcement, such as receiving overly harsh criticism or being scolded by a research mentor, and being held to unreasonable expectations were two of the most detrimental aspects of research affecting student mental health." www.nature.com/articles/s41...
nature.com
Behind the graduate mental health crisis in science - Nature Biotechnology
Survey results identify how scientific research and teaching contribute to the graduate student mental health crisis.
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Avital Rodal @rodallab.bsky.social · 24/11/2024
Application review starts 11/30! Please share, new Bluesky friends!
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IMP @impvienna.bsky.social · 19/11/2024
Are you a #postdoc with an innovative vision for starting your own lab in #Syntheticbiology, #Genomics, #GeneRegulation, #Development, #Cancer, #Immunology or #InfectionBiology? @IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-... Pls share!
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Abdel Mazouzi @amazouzi.bsky.social · 17/11/2024
Post a picture you took (no description) to bring some zen to the timeline.
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