Abstract. In recent years, studies investigating protein–protein interactions on a proteome-wide scale have increased exponentially. These developments wer

Genomics; Chromosome organization; Molecular Genetics; Cancer

In summary, we identify a complex genomic-epigenomic interplay in EC development and progression, altering 3D genome organization to enhance expression of the critical driver ERα.

By Sebastian Gregoricchio (lab Wilbert Zwart, Netherlands Cancer Institute)

The Androgen Receptor (AR) is a ligand-dependent transcription factor that drives prostate cancer development and progression. Although, a detailed effect on AR biology has been described for a number...