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Thijn Brummelkamp

@thijnbrummel.bsky.social
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Director of Research, Netherlands Cancer Institute (NKI), Professor UMC Utrecht, group leader Oncode Institute

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Reposted by Thijn Brummelkamp
Nature Methods @natmethods.nature.com · 04/08/2025
An analysis shows that current deep learning models do not beat linear baselines in predicting gene perturbation effects, thus emphasizing the importance of further method development and evaluation. @const-ae.bsky.social @wkhuber.bsky.social @s-anders.bsky.social www.nature.com/articles/s41...
nature.com
Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines - Nature Methods
The analysis presented in this Brief Communication shows that, despite their complexity, current deep learning models do not outperform linear baselines in predicting gene perturbation effects, thus e...
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Reposted by Thijn Brummelkamp
Danielle Bianchi @daaninthelab.bsky.social · 04/07/2025
In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11
science.org
Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression
Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...
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Reposted by Thijn Brummelkamp
Netherlands Cancer Institute @nkinl.bsky.social · 24/01/2025
Are you graduating this year and ready to start your career in the most meaningful way? This is your chance to get on board. #PhD #CancerResearch ➡️ nki.nl/careers-study/phd-students/nki-phd-program-2025/
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