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Tassos Perrakis @tassosperrakis.bsky.social · 17/09/2025

Check out our #AHMPC site that got a brand new tool! You can now browse complexes by their relationship to GO terms or disease association! ahmpc.eu/cluster.html

ahmpc.eu

Complexity

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Tassos Perrakis @tassosperrakis.bsky.social · 13/09/2025

Featuring #AlphaBridge features from @alvarezsalmoral.bsky.social, with @jonasteuwen.bsky.social and team, our new work from @nkinl.bsky.social nl.bsky.social @oncodeinstitute.bsky.social . Have a look at ahmpc.eu for more!

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bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 13/09/2025

Integrating computational protein structure predictions and genetic dependencies yields an atlas of human multi-protein complexes (AHMPC) www.biorxiv.org/content/10.1101/202…

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bioRxivpreprint @biorxivpreprint.bsky.social · 13/09/2025

Integrating computational protein structure predictions and genetic dependencies yields an atlas of human multi-protein complexes (AHMPC) www.biorxiv.org/content/10.1101/202…

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Tassos Perrakis @tassosperrakis.bsky.social · 04/07/2025

7/11 onwards, the best bit ☺️ Read the whole thread by @daaninthelab.bsky.social : a power walk to a great adventure! Very proud of her and @rborza.bsky.social and the whole team!

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Danielle Bianchi @daaninthelab.bsky.social · 04/07/2025

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

science.org

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression

Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...

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Razvan Borza @rborza.bsky.social · 16/04/2025

🚨New Article Out!! 📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒 🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance ♥️ Thanks for your support Read more here: doi.org/10.1016/j.bm...

Type VI inhibitor targeting both the catalytic site and the tunnel of Autotaxin (ATX). PDB ID: 9FXW

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Tassos Perrakis @tassosperrakis.bsky.social · 19/02/2025

Very happy for my collaborator at the @embl.org Grenoble who led the microdiffractometer engineering project! Very well deserved prize.

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Tassos Perrakis @tassosperrakis.bsky.social · 24/01/2025

An opinion piece by @wouterhm.bsky.social , featuring ideas from all authors which are beautifully illustrated by @rborza.bsky.social : Unlocking the signaling potential of GPI-anchored proteins through lipolytic cleavage www.cell.com/trends/cell-...

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Daniel Hurdiss @danielhurdiss.bsky.social · 27/12/2024

I’m looking for a postdoc to join my team under a recently funded ERC Starting Grant. If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch! Application deadline: January 19th. Please share with your networks 🙏 Job link: tiny.cc/7v33001

tiny.cc

Postdoctoral Researcher in Structural Virology

This project is focused on deciphering the role of virally encoded AAA+ ATPases in the replication cycles of Enteroviruses and Noroviruses.

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Tassos Perrakis @tassosperrakis.bsky.social · 19/12/2024

New features in #AlphaBridge implemented by @alvarezsalmoral.bsky.social 🟥 Customisable cutoff-level for filtering on weak (0.5) or strong (0.9) interactions. 🟦 Displaying the ipTM score, and the brand-new "Contact-ipTM and #AlphaBridge scores. 🟧 Per-interface #AlphaBridge scores.

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Tassos Perrakis @tassosperrakis.bsky.social · 18/12/2024

Few years ago, our collaborators on the "base J" project identified the JBP3 protein. We had determined the crystal structure of the DNA-binding domain, but we could never make sense of the cryo-EM reconstructions of full-length JBP3: nice single particles, but AlphaFold models did not fit the maps.

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Daniel Álvarez Salmoral @alvarezsalmoral.bsky.social · 04/12/2024

Thrilled to present Alphabridge in the Computational Chemistry session at #NWOChains! We aim to facilitate researchers to analyze interacting interfaces in predicted biomolecular structures. Honored to share insights with top chemists in the Netherlands. 🚀🔬 Preprint: www.biorxiv.org/content/10.1...

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Tassos Perrakis @tassosperrakis.bsky.social · 04/12/2024

Greece got exactly 0 ERC consolidator grants this year. 0 grants to mid-career outstanding scientists for curiosity driven research at the highest level. Maybe a statistical fluke? Or a result of chronic national underfunding, insane bureaucracy, unfairness, opacity, nepotism, and low income?

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Tassos Perrakis @tassosperrakis.bsky.social · 03/12/2024

Surely you have been using AlphaFold3 for your research project? If so, have you considered #AlphaBridge to analyze the output for macromolecule complexes prediction? Web server: alpha-bridge.eu Preprint: www.biorxiv.org/content/10.1... New features coming soon!

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Netherlands Cancer Institute @nkinl.bsky.social · 29/11/2024

📢 Applications for the NKI PhD program open from Jan 1 - Feb 28. Join our international research community in Amsterdam, working in cancer biology, AI research & life sciences with leading scientists and top facilities #PhD #CancerResearch More info: bit.ly/3O4bOjq

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Tassos Perrakis @tassosperrakis.bsky.social · 28/11/2024

Today, a cancer patient advocate claimed that: ‘There is excellent research but not enough translation.’ While I appreciate the sentiment, I disagree profoundly. The issue isn’t just about translation—it’s that we don’t yet have enough excellent research to identify what will truly impact patients.

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Tassos Perrakis @tassosperrakis.bsky.social · 28/11/2024

An excellent talk by @andreasbender.bsky.social on the real (and often overstated) impact of AI in drug discovery, offering balanced insights that cut through the hype, along with valuable ideas and suggestions for improvement.

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Netherlands Cancer Institute @nkinl.bsky.social · 27/11/2024

Delaying and shortening the duration of treatment with CDK4/6 inhibitors in patients with metastatic breast cancer leads to similar survival outcomes while reducing toxicity and achieving substantial cost savings, the SONIA trial shows. Read more ➡️ bit.ly/3Oqw7aX

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Tassos Perrakis @tassosperrakis.bsky.social · 25/11/2024

The Royal Academy of Sciences of the Netherlands (KNAW) today joined the protest against the unprecedented cuts on science and education. These cuts, threaten the prosperity, well-being and health of the country. As scientists, we all need to make our voices heard. Stop cutting back on science.

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Netherlands Cancer Institute @nkinl.bsky.social · 19/11/2024

Follow our NKI community go.bsky.app/5EK1wtK

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Tassos Perrakis @tassosperrakis.bsky.social · 17/11/2024

Happy to find @quantamagazine.bsky.social here and cannot resist recommending their protein prediction video (especially as I don’t think I will get again the chance to feature in a video clip alongside two Nobel prize winners).

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Tassos Perrakis @tassosperrakis.bsky.social · 14/11/2024

Nice to see in Bluesky a couple of posts about our new preprint about #CHAOS&Disorder :)

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